A5100458426- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Venous Thromboembolism Diagnosis and Management
- Pregnancy and preeclampsia studies
- Blood Coagulation and Thrombosis Mechanisms
- Head and Neck Cancer Studies
- Iron Metabolism and Disorders
- High Altitude and Hypoxia
- Cancer, Hypoxia, and Metabolism
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Hepatitis B Virus Studies
- Burkholderia infections and melioidosis
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Oral health in cancer treatment
- Hemoglobinopathies and Related Disorders
- Trauma Management and Diagnosis
- Tuberculosis Research and Epidemiology
- Blood properties and coagulation
- Coronary Interventions and Diagnostics
- Nausea and vomiting management
- Human Health and Disease
- Attention Deficit Hyperactivity Disorder
Indira Gandhi Institute of Medical Sciences
2024
Fortis Hospital
2024
Old Dominion University
2024
Jamia Millia Islamia
2018-2024
Eastern Virginia Medical School
2023-2024
Cleveland Clinic
2022-2024
Fortis Memorial Research Institute
2024
S.L. Raheja Hospital
2024
Medanta The Medicity
2024
Maulana Azad Medical College
2024
Significance Hypoxia predisposes otherwise healthy individuals to venous thrombosis, but the underlying mechanism has been unclear. Our study revealed a causal role for nucleotide binding domain, leucine-rich-containing family, pyrin domain containing 3 (NLRP3) inflammasome and IL-1β during hypoxia-induced thrombosis. We further show direct association between NLRP3 hypoxia-inducible factor 1-alpha (HIF-1α) these conditions. Specific interventions within hypoxia–HIF-1α–NLRP3–IL-1β axis in...
Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and vivo experiments. Levels of showed an inverse correlation with load determined by coagulation variables. MiRNA target prediction tools vitro study tissue factor (TF) gene miR-145. The restoration levels...
Background and Objective: Sickle cell disease (SCD) is a genetically inherited disorder that associated with morbidity mortality. Methods: This cross-sectional study was conducted on patients diagnosed SCD to evaluate the knowledge, attitude, practice of patients/guardians using pretested questionnaire. Results Discussion: Of 111 participants, 56 (50.4%) were male. Forty-five participants reported as hereditary disease, only 31 (37%) subjects could be prevented. Fourteen (70%) married their...
Aim Re-tears following rotator cuff repair surgery are a common occurrence. Previous studies have identified several factors that been shown to increase the risk of re-tears. The purpose this study was evaluate rate re-tear primary and identify may contribute rate. Method authors performed retrospective review, looking at surgeries between May 2017 July 2019 in hospital by three specialist surgeons. All methods were included. patients' medical data, including imaging operation records,...
Venous thromboembolism (VTE), a multi-factorial disease, is the third most common cardiovascular disease. Established genetic and acquired risk factors are responsible for onset of VTE. High altitude (HA) also poses as an additional factor, predisposing individuals to VTE; however, its molecular mechanism remains elusive. This study aimed identify genes/pathways associated with pathophysiology deep vein thrombosis (DVT) at HA. Gene expression profiling DVT patients, who developed either sea...
High-altitude (HA) hypoxia exposure is believed to induce venous thromboembolism (VTE) in otherwise healthy individuals, although this needs be fully established. The present study aims ascertain the role of HA aggravating any predisposition toward VTE and explore whether etiology HA-induced different from that closer sea level. We compared manifestation-matched male patients (HAPs) plains level (SLPs) for 54 parameters, including coagulation-related, fibrinolytic, thrombophilic variables,...
The incidences of nosocomial pneumonia in intensive care units (ICUs) India have been reported to range from 9% 58% and are associated with a mortality rate 30-70%. Ceftazidime-avibactam has activity against OXA-48-like carbapenem-resistant
The genetic variants linked with the susceptibility of individuals to VTE are well known; however, studies explaining ethnicity based difference in limited. Present study assesses mutations six candidate genes contributing etiology Indian subjects. comprised 93 patients and 102 healthy controls. A PCR-RFLP analysis was performed for nine following associated VTE: favtor V Leiden (FVL), prothrombin, tissue factor pathway inhibitor (TFPI), fibrinogen-beta, plasminogen activator 1 (PAI-1),...
The incidence of venous thromboembolism (VTE) in cancer patients is 4-9 fold higher compared with the general population. mortality rate and VTE more than 2-fold greater versus those without VTE. Given that pathophysiology thrombosis multi-faceted, investigations mechanisms regulate cancer-associated (CAT) could improve understanding treatment CAT. These include activation coagulation fibrinolytic systems. Tumor cells activate by expressing procoagulant molecules, releasing pro-inflammatory...
Stroke in the young is attributed to prevalence of thrombophilia, however, reports explaining cause mechanisms from Indian populations are largely not known. The information about association inherited thrombophilia and occurrence stroke still missing. Therefore, we describe here 52 cases ischemic which 22 were recurrent 30 first episode along with an equal number healthy controls. Imaging techniques (CT/MRI/Doppler studies) used identify type location infarcts among various regions brain....
Physiological hemostatic balance is a coordinated outcome of counteracting coagulation and fibrinolytic systems. An imbalance procoagulant anticoagulant factors may result in life threatening thromboembolism. Presently, administration the first line therapy for treatment these conditions several anticoagulants have been approved, including various forms heparin. However, polyanionic nature multispecificity heparin pose complications. Generally, polysulfated compounds with antithrombotic...
Background Gingivitis is a common oral health condition characterized by inflammation of the gingiva, which, if left untreated, can progress to more severe forms periodontal disease. Effective hygiene practices play crucial role in managing gingivitis, but comparative efficacy different aids remains unclear. This study aimed evaluate and compare various maintaining patients with considering gender degree gingivitis as potential influencing factors. Methods A total 120 participants were...
Genes related to endothelial function are responsible for the regulation of vascular functions.The aim this study is investigate whether gene-associated polymorphism and their plasma levels can be used predict risk venous thromboembolism (VTE).We studied 133 patients with VTE 164 healthy controls. Endothelin (EDN) G8002A, EDN T1370G, 3A/4A, eNOSG894T, angiotensin-converting enzyme I/D, growth factor C936T, cell protein C receptor A6936G was genotyped by restriction fragment length...
Purpose: A comparison of simultaneous integrated boost (SIB) with sequential (SEQ) using intensity-modulated radiotherapy along concurrent cisplatin in locally advanced head and neck cancer (HNC) was made regard to their survival outcomes toxicity profile.Materials Methods: total 34 patients were enrolled between October 2016 March 2019. They randomized into two arms, SIB SEQB. All treated 6 MV photon beam on Linear Accelerator weekly at 35 mg/m2. Overall (OS) disease-free (DFS) the primary...
Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator protein disulfide isomerase (PDI). Based on in silico analysis we show that QPS binds to b domain PDI (−7.4 kcal/mol) unlike inhibitor quercetin 3-rutinoside (Q3R) at substrate-binding (−8.0 kcal/mol). was synthesized its structure validated using combination FTIR, NMR mass spectral studies. Surprisingly, Q3R is shown enhance the activity purified recombinant PDI. Fluorometric circular dichroism...