A5069604973- Surfactants and Colloidal Systems
- Synthesis and biological activity
- Thermodynamic properties of mixtures
- Photochemistry and Electron Transfer Studies
- Advancements in Transdermal Drug Delivery
- Quinazolinone synthesis and applications
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Advanced Drug Delivery Systems
- Heme Oxygenase-1 and Carbon Monoxide
- Computational Drug Discovery Methods
- Synthesis and Biological Evaluation
- High Altitude and Hypoxia
- Sunflower and Safflower Cultivation
- Advances in Cucurbitaceae Research
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Phytochemicals and Antioxidant Activities
- Free Radicals and Antioxidants
- Curcumin's Biomedical Applications
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Characterization of Pyrroles
- Synthesis and Characterization of Heterocyclic Compounds
- TGF-β signaling in diseases
- Cardiac Ischemia and Reperfusion
Laureate Institute for Brain Research
2025
University of Delhi
2023
Jaypee University of Information Technology
2012-2022
Defence Institute of Physiology and Allied Sciences
2015-2022
PAREXEL International (India)
2021
Institute of Bioinformatics
2014-2017
LNM Institute of Information Technology
2015
Defence Scientific Information & Documentation Centre
2014
Pyrrole is widely known as a biologically active scaffold which possesses diverse nature of activities.
In the present study, impact of potential antimicrobial drug (levofloxacin) on micellar system anionic surfactant (SDS) has been studied.
Nowadays, hybrid drugs containing two or more covalently linked known potential pharmacophores are designed to simultaneously modulate multiple targets of multifactorial diseases overcome the side effects associated with a single drug.
Surfactants are found to enhance the diffusion significantly depending on hydrophobic/hydrophilic group lengths and structure of surfactant molecule. Aggregation properties sodium dodecyl sulfate (SDS) in presence butylated hydroxyanisole (synthetic antioxidant), at a range temperatures (25, 30 35 °C) have been measured by conductometric study aqueous-ethanolic composite solution. The experimental data solutions as function SDS concentration ranging from 1 14 mM dm−3 show inflexion points...
With the aim of producing new biologically active compounds, a series New Pyridine Imidazo [2,1b]-1,3,4-thiadiazole derivatives 4(a–k) were synthesized. All compounds characterized via IR, 1H-NMR and Mass spectral studies. The antimicrobial activity newly synthesized against various bacteria; Bacillus pumillus, Staphylococcus aureus, Vibrio cholera, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, fungi; Candida albicans evaluated. Among tested, 4(a), 4(b), 4(f), 4(h) 4(k)...
Hypoxia induced oxidative stress incurs pathophysiological changes in hypertrophied cardiomyocytes by promoting translocation of p53 to mitochondria. Here, we investigate the cardio-protective efficacy nanocurcumin protecting primary human ventricular (HVCM) from hypoxia damages. hypertrophy was confirmed FITC-phenylalanine uptake assay, atrial natriuretic factor (ANF) levels and cell size measurements. investigated using mitochondrial membrane permeability transition pore blocker...
Nehra, Sarita, Varun Bhardwaj, Santosh Kar, and Deepika Saraswat. Chronic hypobaric hypoxia induces right ventricular hypertrophy apoptosis in rats: therapeutic potential of nanocurcumin improving adaptation. High Alt Med Biol. 17:342-352, 2016.-a sustained work load on the heart ascent to high altitudes promotes (RVH), which eventually undergoes decompensation pathological damage. However, exact set events leading damage remains unidentified. Curcumin is a natural antioxidant...
In this paper, an attempt was made to develop a Quantitative Structure Activity Relationship (QSAR) model on series of quinazoline derivatives acting as Protein tyrosine kinases (erbB-2) inhibitors using Multiple Linear Regression, Principal Component Regression and Partial Least Squares methods. Among these three methods, (MLR) method has come out with very promising result compared other two Various 2D descriptors were calculated used in the present analysis. For validation, dataset...