A5052782053- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Carbohydrate Chemistry and Synthesis
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Chemical Synthesis and Analysis
- Phytochemical Studies and Bioactivities
- Synthesis of Indole Derivatives
- Sphingolipid Metabolism and Signaling
- Glycosylation and Glycoproteins Research
- Microbial Natural Products and Biosynthesis
- Lipid Membrane Structure and Behavior
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Plant biochemistry and biosynthesis
- Phytochemistry and Biological Activities
- Crystallography and molecular interactions
- Catalytic C–H Functionalization Methods
- Advances in Cucurbitaceae Research
- Synthesis and biological activity
- Immune Cell Function and Interaction
- Synthetic Organic Chemistry Methods
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
- Bioactive natural compounds
National Institute for Interdisciplinary Science and Technology
2015-2025
Academy of Scientific and Innovative Research
2015-2025
Queens College, CUNY
2008-2020
Pallium India
2017
Council of Scientific and Industrial Research
2013-2015
The Graduate Center, CUNY
2014
City University of New York
2009-2010
University of Illinois Chicago
2009
Ludwig-Maximilians-Universität München
2008
University of Arizona
2008
Sphingomyelin is a lipid that abundant in the nervous systems of mammals, where it associated with putative microdomains cellular membranes and undergoes alterations due to aging or neurodegeneration. We investigated effect varying concentration cholesterol binary ternary mixtures N-palmitoylsphingomyelin (PSM) 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) using deuterium nuclear magnetic resonance (2H NMR) spectroscopy both macroscopically aligned unoriented multilamellar...
We report the isolation and characterization of four compounds from a cytotoxic fraction F-17, isolated DCM extract of<italic>C. odorata</italic>by bioactivity guided fractionation.
Abstract We report, for the first time, remarkable efficacy of uttroside B, a potent saponin from Solanum nigrum Linn, against liver cancer. The compound has been isolated and characterized leaves plant widely used in traditional medicine is rich resource several anticancer molecules. Uttroside that comprises β-D-glucopyranosyl unit at C-26 furostanol β-lycotetraosyl C-3, ten times more cytotoxic to cancer cell line, HepG2 (IC50: 0.5 μM) than sorafenib 5.8 μM), only FDA-approved drug...
The study evaluated the prediabetic management potential and phytochemical composition of LAGJ. LAGJ administration in a HFD-prediabetic rat model resulted significant reduction conditions reversed fatty liver.
Sphingolipid phosphate analogues bearing 7-(diethylamino)coumarin (DECM) and 4-bromo-5-hydroxy-2-nitrobenzhydryl (BHNB) groups in a photolabile ester bond were synthesized. The ability of the "caged" ceramide 1-phosphate to release bioactive parent molecule upon irradiation at 400−500 nm was demonstrated by stimulation macrophage cell proliferation.
Chrysomycin A isolated from<italic>Streptomyces</italic>sp. OA161 is bactericidal to<italic>Mycobacterium tuberculosis</italic>, methicillin resistant<italic>Staphylococcus aureus</italic>and vancomycin resistant<italic>Enterococcus faecalis</italic>.
• First report on glucocerebrosides consortium (GCs) from unripe banana peel. GCs peel displayed significant anti-inflammatory activity. exhibited remarkable α-glucosidase inhibition potential. Banana represents a waste product of processing industries that can yield high-value products. contains flavonols, tannins, alkaloids, terpenoids, and various phenolic compounds such as catechin, epicatechin, catecholamines. Recent studies have demonstrated the immunomodulatory, anti-inflammatory,...
Easily accessible 3,3′-diindolylmethanes (DIMs) were utilized to generate a focused library of indolo[2,3-b]quinolines (2), chromeno[2,3-b]indoles (3), and 3-alkenyl-oxindoles (4) under 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated oxidative conditions. DIMs with ortho-NHTosyl (NHTs) phenyl group afforded whereas ortho-hydroxy groups yielded (3) (4). The mild conditions excellent yields the products make this method good choice access diverse bioactive molecules from common...
Candidiasis infections are caused by yeasts from the genus Candida. The types of infection range superficial to systemic. Treatment often requires antifungals such as azoles; however, increased use these drugs has led generation with resistance drugs. Here, we describe synergistic anticandidal activity three phenazines—phenazine-1-ol, phenazine-1-carboxylic acid, and phenazine-1-carboxamide. These phenazines were purified Pseudomonas aeruginosa in combination clinically used...
Kuttanad in India is known as 'the rice bowl of Kerala' and renowned for its unique cultivation system that below sea level. However, production this wetland ecosystem seriously threatened by sheath blight disease caused the fungus Rhizoctonia solani, which has resulted a significant decline grain quality 50% loss yield. In present study, we isolated two endophytic Bacillus subtilis strains, NIIST B616 B627, from roots plants growing region tested their efficacy controlling disease. We found...
A metal-free one-pot cascade annulation of acyclic substrates dienaminodioate, cinnamaldehydes and allyl amine was achieved for the synthesis polyfunctional biaryl-2-carbaldehydes.
The present study evaluated antidiabetic potential of fractions Syzygium cumini seeds and identified major polyphenolic compounds in them. Potential α-glucosidase α-amylase inhibition (IC50 1.7 7.62 μg/ml, respectively) was demonstrated by 70% methanol fraction while significant dipeptidyl peptidase-IV (88.1%) fraction. A fourfold increase glucose uptake L6 cells following the pretreatment (26.9%) further confirmed S. seeds. total phenolic (906 mg GAE/g dry weight) flavonoid content (233...