A5053960002- Curcumin's Biomedical Applications
- Natural product bioactivities and synthesis
- Synthesis and biological activity
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Bioactive natural compounds
- Cancer, Lipids, and Metabolism
- Retinoids in leukemia and cellular processes
- Phytochemical compounds biological activities
- Quinazolinone synthesis and applications
- RNA Interference and Gene Delivery
- Phytochemical Studies and Bioactivities
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Autophagy in Disease and Therapy
- Liver physiology and pathology
- Beetle Biology and Toxicology Studies
- Essential Oils and Antimicrobial Activity
- Ginger and Zingiberaceae research
Rajiv Gandhi Centre for Biotechnology
2015-2024
Mahatma Gandhi University
2024
Biotech Park
2024
Government of Kerala
2024
Kerala State Council for Science, Technology and Environment
2024
Indian Institute of Chemical Technology
2014
The University of Texas MD Anderson Cancer Center
2002
Amala Institute of Medical Sciences
1995-1998
Mpala Research Center and Wildlife Foundation
1994
Pharmacologically safe compounds that can inhibit the proliferation of tumor cells have potential as anticancer agents. Curcumin, a diferuloylmethane, is major active component food flavor turmeric (Curcuma longa) has been shown to wide variety cells. The apoptotic intermediates through which curcumin exhibits its cytotoxic effects against are not known, and participation antiapoptotic proteins Bcl-2 or Bcl-xl in curcumin-induced apoptosis pathway established. In present report we...
Cigarette smoke (CS) contains several carcinogens known to initiate and promote tumorigenesis metastasis. Because various genes that mediate carcinogenesis are regulated by nuclear factor-κB (NF-κB), we postulated the effects of CS must be mediated through activation this transcription factor. Therefore, in present report investigated whether cigarette condensate (CSC) activates NF-κB, pathway employed for is similar TNF, one potent activators NF-κB. Our results show treatment human...
Taxol is the best anticancer agent that has ever been isolated from plants, but its major disadvantage dose-limiting toxicity. In this study, we report with mechanism-based evidence curcumin, a nontoxic food additive commonly used by Indian population, sensitizes tumor cells more efficiently to therapeutic effect of Taxol. A combination 5 nm microm curcumin augments effects than alone as evidenced increased cytotoxicity and reduced DNA synthesis in HeLa cells. Furthermore, our results reveal...
We report mechanism-based evidence for the anticancer and chemopreventive efficacy of [6]-gingerol, major active principle medicinal plant, Ginger (Zingiber officinale), in colon cancer cells. The compound was evaluated two human cell lines its cytotoxic effect most sensitive line, SW-480, selected mechanistic evaluation efficacy. non-toxic nature [6]-gingerol confirmed by viability assays on rapidly dividing normal mouse inhibited proliferation induced apoptosis as evidenced externalization...
5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of enzyme thymidylate synthase (TS), essential for synthesis and repair DNA. However, prolonged exposure to 5-FU induces TS overexpression, leads resistance in cancer cells. Several studies have identified curcumin as a potent chemosensitizer against chemoresistance induced by various chemotherapeutic drugs. In this study, we report time, with mechanism-based...
The hydrogel based system is found to be rarely reported for the delivery of hydrophobic drug due incompatibility hydrophilicity polymer network and hydrophobicity drug. This problem can solved by preparing semi-interpenetrating cross-linked tuning so as entrap drugs. current study develop a folic acid conjugated pH sensitive, biocompatible polymeric achieve site specific delivery. For that, we have synthesized PEG acrylic (FA-CLAP) investigated its loading release curcumin. formed was then...
We report the isolation and characterization of four compounds from a cytotoxic fraction F-17, isolated DCM extract of<italic>C. odorata</italic>by bioactivity guided fractionation.
The rate of lung cancer incidence is alarmingly mounting, despite the decline smoking and tobacco consumption. Recent reports indicate a very high correlation between growing fast food culture incidence. Benzo[a]pyrene (B[a]P) potent carcinogen abundantly present in grilled deep-fried smoke. Our previous studies have proved efficacy curcumin curbing B[a]P-induced carcinogenesis. However, poor pharmacokinetic profile compound considerably hampers its potential as an effective chemopreventive....
Cross-linked acrylic hydrogel for the controlled delivery of hydrophobic drugs in cancer therapy G Deepa,1 Arun Kumar T Thulasidasan,2 Ruby John Anto,2 J Jisha Pillai,1 GS Vinod Kumar11Chemical Biology, 2Division Cancer Research, Rajiv Gandhi Centre Biotechnology, Thiruvananthapuram, Kerala, IndiaObjective: To investigate cross-linked hydrogels prepared via inverse emulsion polymerization to entrap poorly aqueous soluble drugs. Polyethylene glycol polymers were synthesized and loading...
Abstract As breast cancer cells often develop chemoresistance, better therapeutic options are in search to circumvent it. Here we demonstrate that human epidermal growth factor receptor-2 (HER-2)-overexpressing resist docetaxel-induced cytotoxicity by upregulating HER-2 and its activity downstream, through Akt mitogen-activated protein kinase (MAPK) pathways. We observed introducing resveratrol as a chemosensitizer docetaxel chemotherapy blocks upregulation activation of addition blocking...
// Arun Kumar T. Thulasidasan 1, 3, * , Archana P. Retnakumari Mohan Shankar 4 Vinod Vijayakurup 1 Shabna Anwar 3 Sanu Thankachan Kavya S. Pillai Jisha J. 2 C. Devika Nandan Vijai V. Alex Teena Jacob Chirayil 2, Sankar Sundaram 5 Gopalakrishnapillai Sankaramangalam and Ruby John Anto Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India Chemical Biology-Nano Drug Delivery Systems, Research Scholar, University Manipal University, Manipal,...
Abstract We report, for the first time, remarkable efficacy of uttroside B, a potent saponin from Solanum nigrum Linn, against liver cancer. The compound has been isolated and characterized leaves plant widely used in traditional medicine is rich resource several anticancer molecules. Uttroside that comprises β-D-glucopyranosyl unit at C-26 furostanol β-lycotetraosyl C-3, ten times more cytotoxic to cancer cell line, HepG2 (IC50: 0.5 μM) than sorafenib 5.8 μM), only FDA-approved drug...
Abstract Cisplatin, a chemotherapeutic agent, is known to induce apoptosis of cancer cells. We examined the role NF‐κB during cisplatin‐induced in two human cervical cell lines, HeLa and SiHa, differ their response cisplatin treatment. found that SiHa cells were relatively more resistant than cytotoxic effects induced by as measured MTT assays. sensitive apoptotic shown increases annexin staining, DNA fragmentation, loss mitochondrial membrane potential. Similarly activities caspases 3, 8, 9...
Lung cancer is the most lethal and almost 90% of lung due to cigarette smoking. Even though nicotine, one major ingredients smoke causative agent for addiction, not a carcinogen by itself, several investigators have shown that nicotine can induce cell proliferation angiogenesis. We observed proliferative index different in lines H1299 (p53-/-) A549 (p53+/+) which indicates mode up-regulation survival signals might be cells with without p53.While low concentrations induced activation NF-κB,...