A5054982708- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Curcumin's Biomedical Applications
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Synthesis and biological activity
- Bioactive natural compounds
- Hepatocellular Carcinoma Treatment and Prognosis
- Wnt/β-catenin signaling in development and cancer
- Advancements in Transdermal Drug Delivery
- Advanced Drug Delivery Systems
- Cancer-related Molecular Pathways
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Management of metastatic bone disease
- Reconstructive Facial Surgery Techniques
- Cancer Immunotherapy and Biomarkers
- Toxin Mechanisms and Immunotoxins
- Nicotinic Acetylcholine Receptors Study
- Myasthenia Gravis and Thymoma
- Cancer, Lipids, and Metabolism
- Cancer therapeutics and mechanisms
- HER2/EGFR in Cancer Research
- Bioactive Compounds and Antitumor Agents
Narayana Health
2021-2025
Memorial Sloan Kettering Cancer Center
2019-2024
Cornell University
2024
Rajiv Gandhi Centre for Biotechnology
2010-2023
Christian Medical College
2015
Sri Venkateswara Institute of Medical Sciences
2013
Pushpagiri Medical College
2011
5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of enzyme thymidylate synthase (TS), essential for synthesis and repair DNA. However, prolonged exposure to 5-FU induces TS overexpression, leads resistance in cancer cells. Several studies have identified curcumin as a potent chemosensitizer against chemoresistance induced by various chemotherapeutic drugs. In this study, we report time, with mechanism-based...
Abstract Purpose: We aimed to investigate genomic correlates underlying extremes of survivorship in metastatic colorectal cancer and their applicability informing survival distinct subsets patients with cancer. Experimental Design: examined differences oncogenic somatic alterations between cohorts demonstrating following complete metastasectomy: ≤2-year (n = 17) ≥10-year 18) survivors. Relevant findings, association overall (OS), were validated two independent datasets 935 stage IV 443...
The rate of lung cancer incidence is alarmingly mounting, despite the decline smoking and tobacco consumption. Recent reports indicate a very high correlation between growing fast food culture incidence. Benzo[a]pyrene (B[a]P) potent carcinogen abundantly present in grilled deep-fried smoke. Our previous studies have proved efficacy curcumin curbing B[a]P-induced carcinogenesis. However, poor pharmacokinetic profile compound considerably hampers its potential as an effective chemopreventive....
Abstract As breast cancer cells often develop chemoresistance, better therapeutic options are in search to circumvent it. Here we demonstrate that human epidermal growth factor receptor-2 (HER-2)-overexpressing resist docetaxel-induced cytotoxicity by upregulating HER-2 and its activity downstream, through Akt mitogen-activated protein kinase (MAPK) pathways. We observed introducing resveratrol as a chemosensitizer docetaxel chemotherapy blocks upregulation activation of addition blocking...
Lung cancer is the most lethal and almost 90% of lung due to cigarette smoking. Even though nicotine, one major ingredients smoke causative agent for addiction, not a carcinogen by itself, several investigators have shown that nicotine can induce cell proliferation angiogenesis. We observed proliferative index different in lines H1299 (p53-/-) A549 (p53+/+) which indicates mode up-regulation survival signals might be cells with without p53.While low concentrations induced activation NF-κB,...
Hes-1 and Hes-5 are downstream effectors of Notch signaling that known to be involved in different aspects neural stem cell proliferation differentiation. Evidence has emerged expression can regulated by alternate pathways independent canonical Notch/CBF1 interaction. This context-dependent differential regulation progenitor gains a lot importance as it would help its exponential expansion without the requirement interaction from neighboring cells during development. Here, we have clearly...
// Minakshi Saikia 1, 3 , Archana P Retnakumari * Shabna Anwar 3, Nikhil Anto 1 Rashmi Mittal 2 Shah Kavya S Pillai Vinod Balachandran Vidya Peter Reeba Thomas and Ruby John Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India Department Maharishi Markandeshwar University, Haryana, Research Scholar, University These authors contributed equaly to this work Correspondence to: Anto, email: rjanto@rgcb.res.in Keywords: acute myeloid leukemia; Ras;...
The objective of this work was to prepare and evaluate ketoprofen-loaded albumin microspheres for intramuscular administration. Microspheres were prepared by emulsion cross-linking method using a 23 factorial design the effect different factors on entrapment efficiency determined. evaluated efficiency, percentage yield, particle size release behaviour. Selected formulations then tested differential scanning calorimetry, X-ray diffraction electron microscopy. Further they analysed residual...
In the clinical management of arthritis, choice nonsteroidal anti inflammatory drug (NSAID) remains confusing and controversial. A common practice on NSAID in arthritis is risk benefit ratio. The main objective this review to addresses arguments for pharmacological use COX-2 inhibitors relation nonselective NSAIDs arthritis. This concluded that, both are equally effective associated with increased GI, renal, CV, adverse effects. Complete understanding patient's comorbid conditions...
The ongoing treatment modalities for breast cancer (BC) primarily rely on the expression status of ER, PR and HER-2 receptors in BC tissues. Our strategy chemosensitization provides new insights to counter chemoresistance, a major obstacle that limits benefits chemotherapy mammary cancers. By utilizing murine model employing NSG mice bearing orthotopic triple-negative (TNBC) xenografts, we have evaluated ability phytochemical curcumin chemosensitizing 5-Fluorouracil (5-FU) differential...
The surgical management of maxillary pathosis results in direct communication between the oral and nasal cavity, imposing problems such as regurgitation, unintelligent speech, difficulty deglutition compromised esthetics. A restoration these defects is not always possible surgically, but prosthetic rehabilitation an established treatment modality. Early can improve quality life reduce psychological trauma caused by excision. Surgical interim obturators placed during initial phase outcome...
Abstract Somatic mutations in JAK2 have been reported to cause myeloproliferative neoplasms, autoimmune disorders, rheumatoid arthritis, and inflammation. protein with PDB id 3FUP was selected for docking analysis via cross‐docking. Molecular of ATP crystal ligand revealed their binding affinities interactions. 3D QSAR models R 2 =0.997 Q =0.984 having high stability predictivity were generated. The biological activity the hit compound obtained from virtual screening, LAS 26879206, predicted...
<h3>Background</h3> Pancreatic Neuroendocrine Carcinomas (PanNECs) are rare with poor prognosis. Over 70% of cases present as advanced disease<sup>1</sup> and traditionally treated platinum plus etoposide, a regimen extrapolated from small cell lung cancer (SCLC). Pivotal SCLC trials (CASPIAN, IMPOWER133) established improved outcomes in patients (pts) who received combination chemotherapy/immunotherapy (ChemoIO) over chemotherapy alone (Chemo); however, there is limited translation these...
<p>Supplementary Methods, References, and Figures</p>
<div>AbstractPurpose:<p>We aimed to investigate genomic correlates underlying extremes of survivorship in metastatic colorectal cancer and their applicability informing survival distinct subsets patients with cancer.</p>Experimental Design:<p>We examined differences oncogenic somatic alterations between cohorts demonstrating following complete metastasectomy: ≤2-year (<i>n</i> = 17) ≥10-year 18) survivors. Relevant findings, association overall (OS), were...
<div>AbstractPurpose:<p>We aimed to investigate genomic correlates underlying extremes of survivorship in metastatic colorectal cancer and their applicability informing survival distinct subsets patients with cancer.</p>Experimental Design:<p>We examined differences oncogenic somatic alterations between cohorts demonstrating following complete metastasectomy: ≤2-year (<i>n</i> = 17) ≥10-year 18) survivors. Relevant findings, association overall (OS), were...
<p>Supplementary Methods, References, and Figures</p>