A5085452203- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Mitochondrial Function and Pathology
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Heme Oxygenase-1 and Carbon Monoxide
- Medicinal Plants and Bioactive Compounds
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Biochemical effects in animals
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
- Phytochemicals and Medicinal Plants
- Medicinal Plants and Neuroprotection
- Hemoglobin structure and function
- Cancer, Hypoxia, and Metabolism
- Phytochemistry and biological activity of medicinal plants
- Genetics and Neurodevelopmental Disorders
- Erythrocyte Function and Pathophysiology
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glioma Diagnosis and Treatment
- Neural dynamics and brain function
All India Institute of Medical Sciences Bhubaneswar
2016-2024
Defence Institute of High Altitude Research
2010-2019
Defence Research and Development Organisation
2012-2018
Defence Institute of Physiology and Allied Sciences
2007-2009
Ministry of Defence
2008
Glioblastoma (GB) is an intrusive and recurrent primary brain tumor with low survivability. The heterogeneity of the microenvironment plays a crucial role in stemness proliferation GB. induces cancer cells by facilitating clonal evolution promoting multidrug resistance, leading to cell progression metastasis. It also important angiogenesis nourish hypoxic environment. There strong interaction neoplastic their surrounding that comprise several immune non-immune cellular components. complex...
Abstract Neuronal damage in hypoxia and several neurodegenerative disorders is invariably associated with oxidative mitochondrial dysfunction. Administration of acetyl‐ L ‐carnitine (ALCAR) on the other hand attenuates neuronal damage, prevents apoptosis, improves energy status hypoxic stress through less understood mechanisms. Becasue biogenesis could be a possible mechanism for ALCAR‐induced improvement bioenergetics neurons, present study aimed at exploring signaling pathways...
Oxygen sensing in hypoxic neurons has been classically attributed to cytochrome c oxidase and prolyl-4-hydroxylases involves stabilization of transcription factors, hypoxia-inducible factor-1α (Hif-1α) nuclear factor erythroid 2-related 2 (Nrf2) that mediate survival responses. On the contrary, release into cytosol during stress triggers apoptosis neuronal cells. We, here advocate redox state neuroglobin (Ngb) could regulate both Hif-1α Nrf2 hypoxia. The hippocampal regions showing higher...
Hypoxia has been reported to cause hippocampal neurodegeneration resulting in learning and memory deficits. In the present study, we investigated potential of salidroside, a glucoside derivative tyrosol, ameliorating hypoxia-induced impairment. Morris water maze test showed improvement spatial salidroside-treated hypoxic rats correlating with increased dendritic intersections arborization. Salidroside administration phosphorylation insulin receptor subunit A (IRA) at Y972, Y1162/63, Y1146...
Hypobaric hypoxia has been reported to cause memory dysfunction. The possible molecular mechanism involved, however, remains be explored. role that glutamate and its receptors play in causing excitotoxicity ischemia neurodegenerative diseases indicates the occurrence of a similar phenomenon hypobaric hypoxia. present study aimed elucidate events occurring at glutamatergic synapses using Sprague-Dawley rats as model system. animals were exposed an altitude 7,600 m for different durations. was...
Acute exposure to hypobaric hypoxia at high altitude is reported cause sympathetic dominance that may contribute the pathophysiology of illnesses. The effect prolonged stay on autonomic functions, however, remains be explored. Thus, present study aimed investigating neural control cardiovascular responses by monitoring heart rate variability (HRV) during chronic hypoxia. Baseline electrocardiography (ECG) data was acquired from volunteers mean sea level (MSL) (<250 m) in Rajasthan. Following...
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating alterations has less studied. In view above, present study is aimed at investigating relative monotony towards during stress. Monotony was a specially designed chamber male Sprague-Dawley rats presence or absence by housing animals singly (SH) pairs (PH). Novel objects were introduced to disrupt housed (SHNO) paired (PHNO). Behavioural...
Abstract Cellular and molecular pathways underlying hypoxic neurotoxicity cell death are multifaceted complex. Although many potentially neuroprotective agents have been investigated, the protection conferred is often inadequate, resulting in their insufficient clinical utility. In light of above, we investigated therapeutic potential mechanism action acetyl‐ L ‐carnitine (ALCAR) protecting hippocampal neurons from hypoxia‐induced cellular death. Results showed decreased viability cells when...
Though acute exposure to hypobaric hypoxia is reported impair cognitive performance, the effects of prolonged on different domains have been less studied. The present study aimed at investigating time dependent changes in performance stay high altitude and its correlation with electroencephalogram (EEG) plasma homocysteine. was conducted 761 male volunteers 25–35 years age who had never baseline data pertaining domain specific EEG homocysteine acquired ≤240 m mean sea level (MSL). were...
Brain-derived neurotrophic factor (BDNF) which is primarily associated with neuronal survivability, differentiation and synaptic plasticity has been reported to mediate neurodegeneration in hypoxia through its p75 Neurotrophin receptors (p75NTR). The molecular events promoting BDNF-mediated pro-death signalling hypoxia, however, still remain an enigma. This study attempts towards deciphering the cascades involved alteration of BDNF isoforms cognate receptor subtypes leading hypoxia. Adult...