A5103116961- Estrogen and related hormone effects
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Cholinesterase and Neurodegenerative Diseases
- Nuclear Receptors and Signaling
- Menopause: Health Impacts and Treatments
- Retinoids in leukemia and cellular processes
- Memory and Neural Mechanisms
- Genetics, Aging, and Longevity in Model Organisms
- Histone Deacetylase Inhibitors Research
- Medicinal Plants and Neuroprotection
- Neuroendocrine regulation and behavior
- Phytoestrogen effects and research
- Alzheimer's disease research and treatments
- Phytochemicals and Medicinal Plants
- Hormonal Regulation and Hypertension
- Drug Transport and Resistance Mechanisms
- Advanced Glycation End Products research
- 14-3-3 protein interactions
- Dietary Effects on Health
- Dementia and Cognitive Impairment Research
- Genetics and Neurodevelopmental Disorders
- Protein Interaction Studies and Fluorescence Analysis
- Genomics, phytochemicals, and oxidative stress
- Retinal Development and Disorders
Banaras Hindu University
2009-2023
Background Scopolamine is a well-known cholinergic antagonist that causes amnesia in human and animal models. Scopolamine-induced rodent models has been widely used to understand the molecular, biochemical, behavioral changes, delineate therapeutic targets of memory impairment. Although this linked decrease central neuronal activity following blockade muscarinic receptors, underlying molecular cellular mechanism(s) particularly effect on neuroplasticity remains elusive. In present study, we...
Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating alterations has less studied. In view above, present study is aimed at investigating relative monotony towards during stress. Monotony was a specially designed chamber male Sprague-Dawley rats presence or absence by housing animals singly (SH) pairs (PH). Novel objects were introduced to disrupt housed (SHNO) paired (PHNO). Behavioural...
Abstract After the interaction of estrogen with ligand binding domain (LBD) mouse receptor‐α (mERα) and hormone‐responsive elements target genes, many nuclear proteins are recruited to regulate expression specific genes. Because it is not known which brain interact LBD or whether these vary age sex, we used pull‐down assay far Western blotting detect five 160, 140, 87, 60, 46 kD in brain. These interacting were identified as PELP1, RIP140, PGC1α, BAF60, ADA3, respectively. The level BAF60...
Abstract Amnesia or memory loss is associated with brain aging and several neurodegenerative pathologies including Alzheimer's disease (AD). This can be induced by a cholinergic antagonist scopolamine but the underlying molecular mechanism poorly understood. study of proteome profiling in hippocampus could provide conceptual insights into mechanisms involved amnesia. To reveal this, mice were administered to induce amnesia impairment was validated novel object recognition test. Using...
The multitude of molecular pathways underlying memory impairment in neurological disorders and aging-related has been a major hurdle against therapeutic targeting. Over the years, neuronal growth promoting factors, intracellular kinases, specific transcription particularly cyclic AMP response element-binding protein (CREB), have emerged as crucial players storage, their disruption accompanies many cognitive disabilities. However, link that can influence these be potential recovery target...
Brain aging associated impairment in synaptic plasticity and memory increases vulnerability for neurodegenerative pathologies. However, lacunae understanding the molecular mechanisms underlying such have hindered development of recovery strategies. In this context, emerging evidences modifying morphology by activity dependent proteases are noteworthy. Neuropsin (NP) is one serine protease implicated acquisition, though it has never been explored brain. Recently, we reported regional...
Estrogen mediates multiple functions in the brain through interaction of estrogen receptor (ER)α and ERβ with a host nuclear proteins that regulate specific gene transcription. We have identified ERAP 140, AIB 1, Trk A, Src, pCREB CREB as interacting mouse brain. Earlier we showed 140 decreased whereas its expression increased aging female mice. Here report pattern is different male mice compared to females. The adult young remained almost similar old was higher than old, which were similar....