A5010372219- Neuroscience and Neural Engineering
- High Altitude and Hypoxia
- Neuroscience of respiration and sleep
- Photoreceptor and optogenetics research
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Phytochemicals and Medicinal Plants
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Potassium and Related Disorders
- Adipose Tissue and Metabolism
- Gallbladder and Bile Duct Disorders
- Eosinophilic Esophagitis
- Advanced Memory and Neural Computing
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Gastrointestinal disorders and treatments
- Dysphagia Assessment and Management
- Pathogenesis and Treatment of Hiccups
- Pancreatitis Pathology and Treatment
- Sleep and Wakefulness Research
- Pharmacological Effects of Medicinal Plants
Carnegie Mellon University
2020-2025
Pt. Jawahar Lal Nehru Memorial Medical College
2015-2024
Institute of Life Sciences
2023
Fortis Memorial Research Institute
2019-2023
Pandit Ravishankar Shukla University
2023
Defence Institute of Physiology and Allied Sciences
2011-2021
Government Medical College
2019
Defence Research and Development Organisation
2019
Medanta The Medicity
2016
University of Delhi
2016
Summary Background Proton pump inhibitors (PPIs) are one of the most widely used drug classes in US and now frontline medications for gastro‐oesophageal reflux disease (GERD) dyspepsia. In a previous work, we observed that transmucosal, upper gastrointestinal (GI) leak exists Barrett’s oesophagus (BO) patients. PPI commonly by Aim To examine if PPI, esomeprazole, affects barrier function GI tract. Methods The sucrose permeability test (SPT) was to assess possible effect on 37...
Withania somnifera root extract has been used traditionally in ayurvedic system of medicine as a memory enhancer. Present study explores the ameliorative effect withanolide A, major component withania and its molecular mechanism against hypoxia induced impairment. Withanolide A was administered to male Sprague Dawley rats before period 21 days pre-exposure during 07 exposure simulated altitude 25,000 ft. Glutathione level glutathione dependent free radicals scavenging enzyme system, ATP,...
Adverse environmental conditions such as hypobaric hypoxia (HH) cause memory impairment by affecting cellular machinery leading to neurodegeneration. Providing enriched environment (EE) is found be beneficial for curing several neurodegenerative disorders. The protective role of EE in preventing HH induced neuronal death has been reported previously but the involved mechanism still not clearly understood. present study an attempt verify impact on spatial during and also explore possible...
Background: Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders. Although growing evidence suggests improvement cognitive performance by psychostimulants during sleep-deprived conditions, impending involved mechanism is rarely studied. Thus, we hypothesized that inflammatory changes might be glial cells activation induced modulation of cytokines SD, which could improved administering...
Abstract Targeted delivery of neurochemicals and biomolecules for neuromodulation brain activity is a powerful technique that, in addition to electrical recording stimulation, enables more thorough investigation neural circuit dynamics. We have designed novel, flexible, implantable probe capable controlled, localized chemical stimulation electrophysiology recording. The was implemented using planar micromachining processes on Parylene C, mechanically biocompatible substrate. shank features...
Hypoxic exposure results in several pathophysiological conditions associated with nervous system, these include acute and chronic mountain sickness, loss of memory, high altitude cerebral edema. Previous reports have also suggested the role hypoxia pathogenesis depression related psychological conditions. On other hand, sub lethal intermittent hypoxic induces protection against future may beneficial effect. Therefore, present study was designed to explore neuroprotective hypobaric (IHH)...
Abstract Objective. Transcranial electrical stimulation (TES) is an effective technique to modulate brain activity and treat diseases. However, TES primarily used stimulate superficial regions unable reach deeper targets. The spread of injected currents in the head affected by volume conduction additional spreading as they move through layers with different conductivities, discussed [1]. In this paper, we introduce DeepFocus, a aimed at stimulating deep structures brain’s “reward circuit”...
<title>Abstract</title> Pulsed transcranial electrical stimulation (pTES) with short (< 1ms) high amplitude (> 20 mA) pulses can elicit suprathreshold neural activity and drive physiological effects such as motor evoked potentials. While this technique could benefit several neurological neuropsychiatric conditions, it is not widely used because the injected current cause substantial pain in scalp. We investigated approaches to reduce scalp sensation of pTES at threshold human subjects....
Abstract Conjugated linoleic acid (CLA) is a collection of octadecadienoic fatty acids that have been shown to possess numerous health benefits. The CLA used in our study was produced by the photoisomerization soybean oil and consists about 20% CLA; this 75% trans – (a mixture t8,t10; t9,t11; t10,t12) isomers. This method could be readily increase content all as food ingredient. objective determine effects CLA‐rich soy oil, fed dietary supplement, on body composition, dyslipidemia, hepatic...
Hypobaric hypoxia (HH) is a major stress factor that associated with physiological, biochemical, molecular and genomic alterations. Brain the organ reacts sensitively to oxygen deprivation, which leads oxidative cognitive function impairment. Our previous studies have reported downregulation of brain derived neurotrophic (BDNF) neurodegeneration memory The aim present study was investigate effect HH exposure on DNA methylation its regulation in BDNF expression, spatial For this purpose,...
Yersinia pestis, the agent of plague, requires Ail (attachment invasion locus) outer membrane protein to survive in blood and tissues its mammalian hosts. is important for both attachment host cells resistance complement-dependent bacteriolysis. Previous studies have shown that interacts with components extracellular matrix, including fibronectin, laminin heparan sulfate proteoglycans, complement inhibitor C4b-binding protein. Here, we demonstrate Ail-expressing Y. pestis strains bind...
A simple, precise and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous estimation of bromhexine hydrochloride, chlorpheniramine maleate, dextromethorphan hydrobromide guaiphenesin in their tablet dosage form. The conditions were standardised using a Chromatopak C18 (25 cm × 4.6 mm i.d. 5 μm) with UV detection at 265 nm, mobile consisted methanol:acetonitrile:0.025 M phosphate buffer (50:25:25, v/v/v). retention times 16.254 min, 12.219...
The development of engineered bone tissue, as a promising alternative to conventional grafts, has so far not proven successful and still remains challenging. Thus, attempts have been made in the present study synthesize polyelectrolyte complex (PEC) scaffolds by blending chitosan (CS) silk fibroin (SF) derived from non-mulberry silkworm (Antheraea pernyi) at three different pH values (5.0, 6.0, 7.0), characterize them terms morphology, ultrastructure mechanical properties with scanning...
Objective. Multichannel intraluminal impedance and manometry (MII-EM) is performed using ten 5-ml swallows each of a liquid viscous solution. However, the manometric diagnosis based solely on results from 10 swallows. The aim this study was to compare esophageal function evaluated with versus combined MII-EM in patients various symptoms. Material methods. Consecutive studies 300 (211F, mean age 54.5 years) were analyzed. diagnoses separated into normal abnormal manometry. MII findings...