A5078160024- Hemoglobinopathies and Related Disorders
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- SARS-CoV-2 and COVID-19 Research
- Erythrocyte Function and Pathophysiology
- T-cell and B-cell Immunology
- Spondyloarthritis Studies and Treatments
- Organ Transplantation Techniques and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Viral Infections and Vectors
- Long-Term Effects of COVID-19
- Multiple Myeloma Research and Treatments
- Dermatology and Skin Diseases
- Blood properties and coagulation
- Blood Coagulation and Thrombosis Mechanisms
- Toxoplasma gondii Research Studies
- Herpesvirus Infections and Treatments
- Psoriasis: Treatment and Pathogenesis
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neonatal Health and Biochemistry
- Heparin-Induced Thrombocytopenia and Thrombosis
Basavatarakam Indo American Cancer Hospital and Research Institute
2023-2025
Christian Medical College, Vellore
2020-2023
Christian Medical College
2020-2023
Cancer Hospital and Research Institute
2023
Creative Commons
2023
Unité de Nutrition Humaine
2022
Third Way
2022
Institute of Medical Sciences
2022
Asian Institute of Gastroenterology
2022
Kovai Medical Center and Hospital
2014
Objective Large data on the clinical characteristics and outcome of COVID-19 in Indian population are scarce. We analysed factors associated with mortality a cohort moderately severely ill patients enrolled randomised trial convalescent plasma. Design Secondary analysis from Phase II, Open Label, Randomized Controlled Trial to Assess Safety Efficacy Convalescent Plasma Limit Associated Complications Moderate Disease. Setting 39 public private hospitals across India during study period 22...
Background: Characterization of reticulo-endothelial activation in COVID-19 may guide treatment. Objectives: To assess and its correlation with disease severity death patients across the entire spectrum severity. Methods: Consecutive hospitalized were studied, similar number each category. Baseline serum ferritin, sCD163 (macrophage markers) plasma von Willebrand factor (VWF) antigen (endothelial marker) levels studied. Clinical parameters D-dimer also The study correlated survival. Results:...
Abstract Background Newborns have limited specific immune capability at birth, owing to delayed and constrained development of adaptive immunity. To supplement this period the mother passively transfers antibodies child either transplacentally or through breast milk. When maternal alloimmunisation occurs foreign fetal red cell surface antigens, stimulating production immunoglobulin G (IgG) antibodies, these IgG can cross placenta cause haemolytic disease fetus newborn. Objective We present...
Objective Microbiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC).We aimed to examine the effect of fecal microbiota transplantation (FMT) anti-inflammatory diet in inducing remission followed by long-term maintenance with patients mild-moderate UC.Design This open-labelled randomized controlled trial (RCT), (simple clinical activity index [SCCAI] 3 -9) endoscopically active UC (ulcerative endoscopic severity [UCEIS] >1) on stable baseline...
Abstract Background and Objectives Maternal antibodies are transferred to the child, predominantly IgG, via transplacental route, mostly IgA through breast milk. Cases reported by us others have shown transfer of red cell allo‐antibodies This study was conducted assess presence isohaemagglutinins in milk, range titres, correlation between milk maternal plasma titres. Materials Methods A total 176 mothers were recruited this study. Breast collected after sufficient feeding established within...
Coated-platelets are sub-population of platelets "coated" with highly procoagulant proteins and phosphatidylserine that sustains thrombin generation. They produced upon dual agonist stimulation by collagen thrombin. This study was conducted to assess if there any difference in the levels coated-platelets patients primary intracranial hemorrhage (PICH) ischemic stroke due large artery atherosclerosis (LAA) as compared healthy controls, see coated-platelet had influence on hemorrhagic...
Type 3 von Willebrand disease (VWD) is a rare autosomal recessive disorder characterized by undetectable Antigen (VWF:Ag). Carriers of type VWD carry one null allele and have factor (VWF) at about 50% normal. The aim this study was to characterize carriers the role Platelet Function Analyzer (PFA-200) in cohort.This cross-sectional where data were collected from (parents/offspring) patients evaluated with activated partial thromboplastin time, VIII, blood group, ristocetin cofactor assay...
ABO incompatible transplants have been performed in 15 patients our institution from June 2012 to December 2013. Antibody titers (IgG) were routinely checked and baseline range was 1:8 till 1:128. All received Rituximab 200 mg IV one week before commencement of plasmapheresis along with MMF Tacrolimus. Pre-operative antibody titre 1:4 or less. Injection Thymoglobulin used for induction maintenance immunosuppression Tacrolimus MMF. Intravenous methylprednisolone administered pre-operatively...
Epidural blood patch (EBP) is performed by injecting autologous into the epidural space using a Tuohy needle. Certain clinical scenarios mandate an catheter (EC)-assisted EBP. Collecting in 20-ml versus 5-ml syringe appears to influence quality of clot. This vitro study compared techniques performing EC-assisted EBP on clotting time (CT), clot retraction (CR) and haemolysis.This was haematology laboratory. Five consented adult healthy male volunteers donated blood. In technique, injected...
The relation between sickle cell disease (SCD) and malaria is captivating where sickling of the infected red blood cells (RBCs) causes premature hemolysis parasite death. Although patients with trait are relatively protected, can often lead to marked anemia in them due hemolysis. We report an unusual case a child homozygous SCD presenting falciparum had hyper parasitemia severe which completely resolved following treatment. Clinical suspicion our arose considering endemic nature country. two...
Background: Large data on the clinical characteristics and outcome of COVID-19 in Indian population are scarce. We analyzed factors associated with mortality a cohort moderately ill patients enrolled multicentre randomized trial convalescent plasma. Methods: Demographic, clinical, laboratory, treatment, were extracted from electronic records. Factors explored using univariate multivariable Cox regression analysis expressed as hazard ratio (HR) 95% confidence intervals (CI). Findings:...