A5078123308- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Blood groups and transfusion
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Blood donation and transfusion practices
- Organ Donation and Transplantation
- Liver Disease and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Transplantation: Methods and Outcomes
- Blood transfusion and management
- Hemoglobinopathies and Related Disorders
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Cytomegalovirus and herpesvirus research
- Diabetes and associated disorders
- Poisoning and overdose treatments
- Renal and Vascular Pathologies
- Erythrocyte Function and Pathophysiology
- Autoimmune Bullous Skin Diseases
- HIV Research and Treatment
- Viral Infections and Vectors
- Blood disorders and treatments
Christian Medical College, Vellore
2015-2024
Christian Medical College
2001-2023
Royal Brisbane and Women's Hospital
2023
Bangalore Baptist Hospital
2023
Royal Darwin Hospital
2023
Creative Commons
2023
Unité de Nutrition Humaine
2022
Third Way
2022
Institute of Medical Sciences
2022
Asian Institute of Gastroenterology
2022
Objectives: Although celiac disease (CeD) affects 1% of people in the northern part India, it is believed to be uncommon southern and northeastern parts because significant differences dietary pattern ethnicity. We estimated prevalence CeD these three populations. In a subset, we also investigated HLA-DQ 2/8 allelotype grain consumption. Methods: A total 23,331 healthy adults were sampled from regions India—northern (n=6207), (n=8149), (n=8973)—and screened for using IgA anti-tissue...
Hepatitis B virus (HBV) genotypes differ in their potential for causing disease. Consecutive patients with chronic HBV infection (CHBV) (n=122) and blood donors (n=67) positive hepatitis surface antigen DNA were genotyped using polymerase chain reaction-restriction fragment-length polymorphism. The ratio of male to female subjects was significantly higher the donor group than CHBV (P=.0004). Among CHBV, genotype D detected 57.3%, A 18%, C 11.5%. Only donors. difference between detection rate...
One hundred ninety patients underwent 197 HLA-matched related allogeneic stem cell transplantation for a diagnosis of beta thalassemia major at our center. The median age (+/-SD) was 7+/-4.1 years, and there were 129 (68%) males. Age liver size as continuous variables significantly associated with an adverse outcome. Using receiver operator characteristics curve plot analysis, cutoff values 7 years 5 cm size, respectively, the highest likelihood ratio impact. On multivariate analysis...
India with a population of 1.2 billion has renal transplantation rate 3.25 per million population. The major cause chronic kidney disease is hypertension and diabetes. crude age-adjusted incidence rates end-stage are estimated to be 151 232 population, respectively, in India. There was remarkable lack knowledge the public about deceased organ donation until decade ago. However, role played by media nongovernmental organizations partnership government emphasized implemented donor certain...
Objective Large data on the clinical characteristics and outcome of COVID-19 in Indian population are scarce. We analysed factors associated with mortality a cohort moderately severely ill patients enrolled randomised trial convalescent plasma. Design Secondary analysis from Phase II, Open Label, Randomized Controlled Trial to Assess Safety Efficacy Convalescent Plasma Limit Associated Complications Moderate Disease. Setting 39 public private hospitals across India during study period 22...
Ingestion of phosphorus-containing rodenticide is an important cause acute liver failure (ALF) in agrarian communities southern and western India. In Tamil Nadu (TN), it was estimated that among 1584 cases hepatotoxicity (RH), 554 (35%) had died 2019.1Govindarajan R. Ramamoorthy G. Shanmugam R.M. et al.Rodenticide ingestion Nadu, India.Indian J Gastroenterol. 2021; 40: 373-379Crossref PubMed Scopus (12) Google Scholar As highlighted recently The Lancet Gastroenterology Hepatology, high...
Dendritic cells (DC) are antigen-presenting involved in induction and regulation of immune responses. We investigated the impact number infused day 28 dendritic on development acute chronic GVHD (aGVHD, cGVHD). Monocytoid (MC) plasmacytoid (PC) were characterized as lin(-)HLA-DR(+)CD11c(+) lin(-)HLA-DR(+)CD123(+), respectively. Sixty-eight consecutive patients who underwent HLA matched related granuloyte-colony stimulating factor (G-CSF) mobilized allogeneic PBSCT, from February 2005 to May...
In developing countries such as India, extending donor-swap transplantation (DSTx) to human leukocyte antigen (HLA)-mismatched patient-donor pairs would increase well-matched living donor kidney rates, resulting in use of less immunosuppression and expenses, lower infective morbidity, better survival. A model for DSTx based on HLA matching is presented.Consecutive class 1 (A, B) tests prospective renal allograft recipients their related donors, performed at a single center India was analyzed...
Two cases are described of previously unreported false positivity on the Luminex crossmatch assay due to non HLA specific antibodies directed against beads. In both indicated presence donor class II antigens, which was not substantiated by clinical scenario or other assays. We could demonstrate specificity these through using same in a modified form where beads were unexposed cell lysate and therefore did carry antigens at all. These further serve emphasize absolute necessity correlating...
Abstract: Impact of pretransplant splenectomy in patients with β‐thalassemia major undergoing an allogeneic SCT has never been addressed. Twenty‐seven class III (29 transplants) had a splenectomy. The outcome these 29 transplants was compared 76 who did not have Patients the group were older (11.7 ± 5.0 vs. 8.5 3.5 yr; p = 0.003) and larger liver size (5.7 1.8 4.4 1.6 cm; 0.000). Splenectomized significantly faster time to ANC >500/mm 3 (15.4 5.9 17.5 4 days; 0.002) platelet >20 000/mm...
Purpose: In India, HIV-2 epidemic is alongside with HIV-1. Blood banks are introducing nucleic acid testing (NAT) for screening. The limitation of NAT systems the inability to detect HIV-2. Materials and Method: An analysis HIV screening a blood bank at tertiary care center from 1998 2007 was carried out. Results: A total 175026 donors were screened by serological assays 789 reactive antibody. Only 478 (61%) confirmed positive Western blot/immunoblot. There 465 (97.2%) donations HIV-1, 6...
ABSTRACT Background Childhood-onset psoriasis (COP), a distinct clinical entity, may be associated with HLA-Cw6 positivity and metabolic cardiovascular complications. There is some evidence that more extensive or severe disease lower in Asian patients than Caucasians. We describe the profile, prevalence of allele, syndrome (MetS) vitamin D deficiency Indian COP. Methods In this cross-sectional hospital-based study over 15 months (June 2010–August 2011), 108 consecutive onset ≤16 years were...
Abstract Background Newborns have limited specific immune capability at birth, owing to delayed and constrained development of adaptive immunity. To supplement this period the mother passively transfers antibodies child either transplacentally or through breast milk. When maternal alloimmunisation occurs foreign fetal red cell surface antigens, stimulating production immunoglobulin G (IgG) antibodies, these IgG can cross placenta cause haemolytic disease fetus newborn. Objective We present...
Objective Microbiome and dietary manipulation therapies are being explored for treating ulcerative colitis (UC).We aimed to examine the effect of fecal microbiota transplantation (FMT) anti-inflammatory diet in inducing remission followed by long-term maintenance with patients mild-moderate UC.Design This open-labelled randomized controlled trial (RCT), (simple clinical activity index [SCCAI] 3 -9) endoscopically active UC (ulcerative endoscopic severity [UCEIS] >1) on stable baseline...