Anita Desai
A5046544744- Mosquito-borne diseases and control
- Viral Infections and Vectors
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS Research and Interventions
- COVID-19 Clinical Research Studies
- Virology and Viral Diseases
- Infectious Encephalopathies and Encephalitis
- Vector-borne infectious diseases
- Animal Virus Infections Studies
- COVID-19 epidemiological studies
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Rabies epidemiology and control
- Herpesvirus Infections and Treatments
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Plant Virus Research Studies
- Malaria Research and Control
- HIV-related health complications and treatments
- Immune Cell Function and Interaction
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Fungal Infections and Studies
National Institute of Mental Health and Neurosciences
2016-2025
Pandit Deendayal Petroleum University
2025
Karnatak University
2024
Christian Medical College & Hospital
2023
University of Liverpool
2023
Indira Gandhi Institute of Child Health
2023
St.John's Medical College Hospital
2023
Bangalore Medical College and Research Institute
2023
Walton Centre
2023
Aintree University Hospitals NHS Foundation Trust
2023
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in the state Maharashtra late 2020 and spread throughout India, outcompeting pre-existing lineages including B.1.617.1 (Kappa) B.1.1.7 (Alpha)
Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity >50% by 2021. During April 2021, city became overwhelmed COVID-19 cases fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains growth advantage Delta through combination increased transmissibility reduced sensitivity to immune responses generated against earlier variants...
<ns3:p>Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations biological concern were reported, one the United Kingdom and South Africa. Using a combination data from routine surveillance, genomic sequencing international travel we track dispersal lineages B.1.1.7 B.1.351 (variant 501Y-V2). We account for potential biases surveillance efforts by including passenger volumes location where lineage was first London Africa...
<ns3:p>Late in 2020, two genetically-distinct clusters of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with mutations biological concern were reported, one the United Kingdom and South Africa. Using a combination data from routine surveillance, genomic sequencing international travel we track dispersal lineages B.1.1.7 B.1.351 (variant 501Y-V2). We account for potential biases surveillance efforts by including passenger volumes location where lineage was first London Africa...
Japanese encephalitis (JE) virus (JEV) is an important cause of in children South and Southeast Asia. However, the majority individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue (DENV) cocirculates many JEV-endemic areas, clinical data suggest cross-protection between DENV JEV. To address role T cell responses protection against JEV, we conducted first full-breadth analysis human memory response using a synthetic...
BackgroundThe huge surge in COVID-19 cases Karnataka state, India, during early phase of the pandemic especially following return residents from other states and countries required investigation with respect to transmission dynamics, clinical status, demographics, comorbidities mortality. Knowledge on role symptomatic asymptomatic SARS-CoV-2 was not available.MethodsThe study included all reported March 8 - May 31, 2020. Individuals a history international or domestic travel high burden...
Brain infections pose substantial challenges in diagnosis and management carry high mortality morbidity, especially low-income middle-income countries. We aimed to improve the early of patients admitted hospital (adults aged 16 years older children >28 days) with suspected acute brain at 13 hospitals Brazil, India, Malawi. With stakeholders, policy makers, patient public representatives, we co-designed a multifaceted clinical laboratory intervention, informed by an evaluation routine...
Millions of domestic and wild European rabbits (Oryctolagus cuniculus) have died in Europe, Asia, Australia New Zealand during the past 17 years following infection by Rabbit haemorrhagic disease virus (RHDV). This highly contagious deadly was first identified China 1984. Epidemics RHDV then radiated across Europe until apparently appeared Britain 1992. However, this concept radiation a new virulent from is not entirely consistent with serological molecular evidence. study shows, using...
Abstract Chikungunya virus (CHIKV) is a mosquito-borne alphavirus best known for causing fever, rash, arthralgia, and occasional neurologic disease. By using real-time reverse transcription–PCR, we detected CHIKV in plasma samples of 8 (14%) 58 children with suspected central nervous system infection Bellary, India. was also the cerebrospinal fluid 3 children.
Dengue is a major public health problem worldwide. Assessment of adaptive immunity important to understanding immunopathology and define correlates protection against dengue virus (DENV). To enable global assessment CD4+ T cell responses, we mapped HLA-DRB1-restricted DENV-specific epitopes in individuals previously exposed DENV the general population dengue-endemic region Managua, Nicaragua. HLA class II Managua were identified by an vitro IFNγ ELISPOT assay. cells purified magnetic bead...
Chikungunya (CHIKV) is an emerging arboviral infection of public health concern in India contributing to widespread morbidity. The precise molecular events occurring early the have not been well understood. Cytokines/chemokines are suspected play a key role its pathogenesis. Very few studies correlated plasma levels cytokines/chemokines with diagnostic markers such as viral loads and presence CHIKV IgM antibodies. Understanding these dynamics phase likely provide insight into evolution...
BackgroundAnnual outbreaks of acute encephalitis syndrome pose a major health burden in India. Although Japanese virus (JEV) accounts for around 15% reported cases, the aetiology most cases remains unknown. We aimed to establish an enhanced surveillance network and use standardised diagnostic algorithm conduct systematic evaluation India.MethodsIn this large-scale, study India, patients presenting with (ie, onset fever altered mental status, seizure, or both) any 18 participating hospitals...
To investigate the prognostic role of tumour necrosis factor (TNF) in Japanese encephalitis virus (JEV) infection, we measured immunoreactive forms TNF concentrations serum and cerebrospinal fluid (CSF) 47 laboratory-confirmed cases JE. It was observed that levels were elevated (> 15 pgm/ml) all samples (range 19.4-923.8 pg/ml), while 46/47 CSF 10.8-376 pg/ml). The mean (SD) fatal 234.34 pg/ml (304.40) as compared to 85.31 (SD 153.92) nonfatal cases. Similar observations also made with...
Abstract Immunological and virological evidence for persistence of Japanese encephalitis virus (JEV) in the human nervous system is described 16/323 (5%) laboratory‐confirmed cases encephalitis. In 9/16 patients, JEV specific IgM antibodies were detected CSF even at 50–180 days after onset symptoms. Similarly, 7/16 apart from antibodies, viral antigen was also present beyond third week illness one patient it could be 117 days. Infectious isolated 3/16 patients. patient, on three consecutive...
Abstract Chikungunya fever a re‐emerging infection with expanding geographical boundaries, can mimic symptoms of other infections like dengue, malaria which makes the definitive diagnosis important. The present study compares utility four laboratory diagnostic methods viz. IgM capture ELISA, an in house reverse transcription PCR for fever, TaqMan real‐time PCR, and one step transcription‐loop mediated isothermal amplification assay (RT‐LAMP). Out 70 serum samples tested, 29 (41%) were...
Aims To investigate whether the degree of albuminuria reduction observed in ALTITUDE trial is associated with renal and cardiovascular protection, secondly, was too small to afford clinical benefit. Methods In a post hoc analysis 8561 patients type 2 diabetes chronic kidney disease or we examined effect changes at 6 months on outcomes using C ox proportional hazard regression. Results The median change first aliskiren arm −12% (25th 75th percentile: −48.7_to_ +41.9%) 0.0% −40.2_to_55%)...