A5023778657- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV, Drug Use, Sexual Risk
- Adolescent Sexual and Reproductive Health
- Respiratory Support and Mechanisms
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Impact and Responses
- Mosquito-borne diseases and control
- HIV-related health complications and treatments
- Tuberculosis Research and Epidemiology
- Parasitic Diseases Research and Treatment
- Natural product bioactivities and synthesis
- Parasites and Host Interactions
- Virology and Viral Diseases
- Viral Infections and Vectors
- HIV/AIDS oral health manifestations
- Parasitic Infections and Diagnostics
- Clostridium difficile and Clostridium perfringens research
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Microbial Natural Products and Biosynthesis
Centre International De Reference Chantal Biya
2016-2025
Université de Yaoundé I
2016-2025
University of Buea
2019
Catholic University of Central Africa
2017
Université de Dschang
2017
South African Tuberculosis Vaccine Initiative
2015
Novartis (Singapore)
2009
New England Biolabs (United States)
1993-1996
National Institute of Allergy and Infectious Diseases
1995
National Institutes of Health
1995
The magnitude of intestinal parasitic infection in acquired immunodeficiency syndrome patients requires careful consideration the developing world where poor nutrition is associated with hygiene and several tropical diseases. However, there have been very few studies addressing this issue Cameroon. This study was conducted to determine prevalence parasitosis HIV/AIDS Dschang -Cameroon. Stool blood specimens from control group were screened respectively for parasites HIV antibodies....
Dengue is a major public health problem worldwide. Assessment of adaptive immunity important to understanding immunopathology and define correlates protection against dengue virus (DENV). To enable global assessment CD4+ T cell responses, we mapped HLA-DRB1-restricted DENV-specific epitopes in individuals previously exposed DENV the general population dengue-endemic region Managua, Nicaragua. HLA class II Managua were identified by an vitro IFNγ ELISPOT assay. cells purified magnetic bead...
Dengue virus (DENV) causes a spectrum of diseases ranging from asymptomatic, mild febrile to life-threatening illness: dengue hemorrhagic fever. The main clinical symptom is fever, similar that malaria. prevalence infection, alone or in association with other endemic infectious children Cameroon unknown. aim this study was determine the dengue, malaria and HIV presenting fever associated risk factors. overall 20.2%, Malaria cases were 52.7% represented 12.6%. dengue-HIV co-infection 6.0%...
The flavivirus envelope glycoprotein (E) is responsible for viral attachment and entry by membrane fusion. Its ectodomain the primary target of humoral immune response. In particular, C-terminal Ig-like domain III E, which exposed at surface particle, forms an attractive antigen raising protective monoclonal antibodies (mAb). 9F12, a mouse mAb raised against dengue virus (DENV) serotype 2 recombinant III, cross-reacts with corresponding domains from other three DENV serotypes also West Nile...
Background: Human immunodeficiency viruses (HIV) and acquired syndrome (AIDS) remain a global public health problem. Other sexually transmitted infections (STIs) are aggravating factors.Aim: This study aimed to assess the prevalence identify new cases of HIV STIs, as well their associated risk factors.Setting: Political insecurity in northern regions Cameroon has led population displacement, weakening an already fragile system.Methods: A cohort 684 consenting participants from north far were...
Abstract Filarial infection is characterized by an immune response associated with the production of Ag-specific IgG4 and IgE IL-4 IL-5. To identify filarial Ags capable inducing such responses to analyze role themselves play in sustaining it, 24 recombinant parasite proteins were screened for their ability be recognized sera from 67 individuals tissue-invasive infections. Among that or Abs 25% more, two selected on basis elicit polyclonal IgE/IgG4 vitro. Ov27 (analogous Ov7/cystatin, a...
Monocytes and macrophages are target cells for dengue infection. Besides their potential role virus replication, activated monocytes/macrophages produce cytokines that may be critical pathology. To study the in vivo of monocytes we depleted IFN-alphabetagammaR knockout mice with clodronate liposomes before Although less was first recovered draining LN absence macrophages, monocyte/macrophage depletion eventually resulted a ten-fold higher systemic viral titer. A massive infiltration...
Objective/background: According to estimates by the World Health Organization, there were 9.6 million new tuberculosis (TB) cases in 2014: 5.4 among men, 3.2 women, and 1.0 children. There also 1.5 TB deaths. Although are potent anti-TB molecules, misuse of these drugs addition inconsistent or partial treatment have led development multidrug-resistant extensively drug-resistant TB. It is established that plants harbor microorganisms, collectively known as endophytes, which produce...
The inflammatory profile of chronic obstructive pulmonary disease (COPD) related to tobacco is known in certain studies while that the post tuberculosis form not yet known. This study aimed evaluate levels neutrophils, macrophages and lymphocytes cells sputum COPD patients with history smoking or anterior tuberculosis. Enumeration samples was analyzed using standard microscopy.We enrolled 92 participants, 46 (50%) were subjects comprising 22 (47.83%) smokers 24 (52.17%) healthy persons...
Background Human Immunodeficiency Virus infection (HIV) remains a public health concern in Cameroon that requires regular surveillance for informed policy-making to guide programmatic interventions. Using data from the 2016 HIV national sentinel survey Cameroon, we ascertained prevalence and factors associated with risk of among pregnant women Methods A cross-sectional study was conducted throughout 10 regions targeting 7000 first antenatal care (ANC-1) attendees (4000 urban 3000 rural...
Abstract Multiple factors, such as immune disruption, prophylactic co-trimoxazole, and antiretroviral therapy, may influence the structure function of gut microbiome children infected with HIV from birth. In order to understand whether infection altered relate changes in status, virological response pediatric ART regimens, we characterized 87 HIV-infected 82 non-exposed HIV-negative Yaounde, a cosmopolitan city Cameroon. We found that living had significantly lower alpha diversity their beta...
The testing of dried blood spots (DBSs) for human immunodeficiency type 1 (HIV-1) proviral DNA by PCR is a technology that has proven to be particularly valuable in diagnosing exposed infants. We implemented this HIV-1 early infant diagnosis (EID) and RNA viral load determination infants born HIV-1-seropositive mothers from remote areas Cameroon. samples were collected between December 2007 September 2010. Fourteen thousand seven hundred sixty-three (14,763) DBS HIV-positive 108 sites...
Objective/Background: Tuberculosis (TB) is a re-emerging disease with the advent of human immunodeficiency virus/AIDS infections. Discovered in 1959, diagnosed by various approaches and treated antibiotics, treatment TB infection still poses public health concerns. Many cases resistance cross-resistance are observed. Diagnosis culture, which considered as standard method, takes too long (20–30days) not suitable for extrapulmonary TB. QuantiFERON test, an indirect immunoassay based on blood,...
Background: Despite improvement in HIV prevention of mother-to-child transmission (PMTCT), there are still over 1,500 African infants newly infected daily. PMTCT elimination requires antiretroviral therapy (ART) throughout pregnancy and breastfeeding periods, while early infant diagnosis (EID) implies treatment for those infected. Our study aimed at assessing the utility EID program data evaluating implementation Cameroon, identifying efficacy existing interventions options on events...
Despite the progress in Prevention of Mother-to-Child Transmission HIV (PMTCT), paediatric epidemic remains worrying Cameroon. prevalence rate for population pregnant women was 7.6 % 2010 The extent is needed to inform policymakers. We developed a stochastic simulation model estimate number new infections through MTCT based on observed uptake services during different steps PMTCT cascade Cameroon 2011. Different levels also assessed. A discrete events computer simulation-based approach with...
Increasing the longevity of people living with HIV (PLHIV) around world has been accompanied by an increase in prevalence cardiovascular disease (CVD) risk factors and morbidity. The impact these trends on epidemiology CVD among PLHIV is less clear. aim this study was to assess for CVD, estimate risks at 10 years aged 50 above.This a descriptive analytical carried out Mvog Ada District Hospital Yaounde, Cameroon from January 2020 2021. Descriptive bivariate analyses were used present data....
Genetic variants of the genes encoding Human Immunodeficiency Virus-1 (HIV-1) co-receptors and their ligands, like CC-Chemokine Receptor 5 delta 32 mutation (CCR5-Delta32), CCR5 promoter A/G (Adenine/Guanine), 2 64 isoleucine (CCR2-64I) Stromal cell-derived Factor 3'A (SDF1-3'A), are involved in susceptibility to HIV-1 infection progression. The prevalence these mutations varies by Region. However, little is known about distribution population Dschang, located West Region Cameroon. HIV...
The Republic of Congo is on the World Health Organization (WHO) list 'high burden' countries for tuberculosis (TB) and HIV. TB leading cause death among HIV-infected patients in Congo. In this viewpoint, available data HIV are reviewed, gaps bottlenecks that National Control Program (NTCP) faces discussed. Furthermore, priority requirements developing implementing collaborative service activities identified. control programs operate as distinct entities with separate case management plans....
Abstract A new dimeric naphtho- γ -pyrone, 2-hydroxydihydronigerone ( 1 ), along with five compounds, nigerone 2 pyrophen 3 kojic acid 4 4-(hydroxymethyl)-5-hydroxy-2 H -pyran-2-one 5 and p -hydroxyphenylacetic 6 was isolated from an endophytic fungus Aspergillus niger AKRN associated the roots of Entandrophragma congoënse . The structure compound has been elucidated using spectroscopic data including 1D 2D NMR as well high-resolution mass spectrometry. Compounds – showed weak antimicrobial...
The chemical investigation of the EtOH extract from stem bark Trichilia monadelpha (Thonn.) J. De Wilde afforded two new limonoids (1 and 2): 24-acetoxy-21,25-dihydroxy-21,23-epoxytirucall-7-en-3-one (1) (6R)-1-O-deacetylkhayanolide E (2), together with eleven known compounds (3-13), including additional limonoids, flavonoids, triterpenoids, steroids, fatty acid. Their structures were determined using 1D- 2D-NMR experiments, ESI mass spectrometry, single crystal X-ray diffraction analysis....