Sadeesh Srinathan
A5085030861- Cardiac, Anesthesia and Surgical Outcomes
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Respiratory Support and Mechanisms
- Esophageal Cancer Research and Treatment
- Metabolomics and Mass Spectrometry Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 and healthcare impacts
- Neonatal Respiratory Health Research
- Pleural and Pulmonary Diseases
- Hemodynamic Monitoring and Therapy
- Atrial Fibrillation Management and Outcomes
- Trauma and Emergency Care Studies
- Gastric Cancer Management and Outcomes
- Aortic aneurysm repair treatments
- Meta-analysis and systematic reviews
- Pericarditis and Cardiac Tamponade
- Cardiac Health and Mental Health
- Cancer, Hypoxia, and Metabolism
- Bariatric Surgery and Outcomes
- Airway Management and Intubation Techniques
- Cardiac Arrest and Resuscitation
- Clinical practice guidelines implementation
- Ultrasound in Clinical Applications
- Diverticular Disease and Complications
University of Manitoba
2016-2025
Health Sciences Centre
2014-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2022
Queen Elizabeth Hospital Birmingham
2021-2022
University of Birmingham
2020-2021
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
To determine the 1-year risk of stroke and other adverse outcomes in patients with a new diagnosis perioperative atrial fibrillation (POAF) after non-cardiac surgery.The PeriOperative ISchemic Evaluation (POISE)-1 trial evaluated effects metoprolol vs. placebo 8351 patients, POISE-2 compared effect aspirin placebo, clonidine 10 010 patients. These trials included with, or at of, cardiovascular disease who were undergoing surgery. For purpose this study, we combined POISE datasets, excluding...
Optimised use of kidney function information might improve cardiac risk prediction in noncardiac surgery.
To review 13 years' data from a unit for grown ups with congenital heart disease (GUCH) to understand the change in surgical practice.Records were reviewed of patients over 16 years age undergoing surgery between 1 January 1990 and 31 December 2002 dedicated GUCH unit. Patients atrial septal defects included but not those Marfan's syndrome or first procedure bicuspid aortic valves. Three equal time periods 52 months analysed.Of 474 operations performed, 162 (34.2%) repeat operations. The...
Surgical jejunostomy tubes are a routine part of elective esophagectomies in patients with carcinomas and provide route for nutritional support those who experience complications. We wished to determine how frequently oral intake is delayed the amount nutrition delivered via tube.We reviewed charts all adults undergoing esophagectomy carcinoma between January 2000 June 2008. determined proportion unable resume after 8 days each days.In all, 111 underwent carcinoma, 103 had tube placed. The...
We carried out a pilot randomized controlled study to determine the feasibility of large trial evaluating impact colchicine versus placebo on postoperative atrial fibrillation or flutter (POAF) among patients undergoing lung resection surgery.Patients ≥55 years age surgery were randomly assigned receive 0.6 mg starting few hours before surgery. Postoperatively, received twice daily for an additional 9 days. Our outcomes included period time required recruit 100 patients, completeness...
Background: Myocardial injury after noncardiac surgery (MINS) is common and of prognostic importance. Little known about MINS in orthopaedic surgery. The diagnostic criterion for was a level ≥0.03 ng/mL on non-high-sensitivity troponin T (TnT) assay due to myocardial ischemia. Methods: We undertook an international, prospective study 15,103 patients ≥45 years age who had inpatient surgery; 3,092 underwent Non-high-sensitivity TnT assays were performed postoperative days 0, 1, 2, 3. Among...
Oxidised phosphatidylcholines (OxPCs) are produced under conditions of elevated oxidative stress and can contribute to human disease pathobiology. However, their role in allergic asthma is unexplored. The aim this study was characterise the OxPC profile airways after allergen challenge people with airway hyperresponsiveness (AHR) or mild asthma. capacity OxPCs pathobiology associated also be determined. Using bronchoalveolar lavage fluid from two cohorts, species were quantified using...
Metabolic alterations in malignant cells play a vital role tumor initiation, proliferation, and metastasis. Biofluids from patients with non–small cell lung cancer (NSCLC) harbor metabolic biomarkers potential clinical applications. In this study, we assessed the changes profile of early-stage NSCLC using mass spectrometry nuclear magnetic resonance spectroscopy before after surgical resection. A single cohort 35 provided total 29 32 pairs urine serum samples, respectively, pre-and...
The Esophagectomy Complications Consensus Group (ECCG) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA) have set standards in reporting outcomes after oesophagectomy. Reporting from selected high-volume centres or centralized national cancer programmes may not, however, be reflective of true global prevalence complications. This study aimed to compare complication rates oesophagectomy these existing sources with those an unselected international cohort Oesophago-Gastric Anastomosis...