A5020364857- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Colorectal and Anal Carcinomas
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Atrial Fibrillation Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Cardiac electrophysiology and arrhythmias
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Sarcoma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Ion channel regulation and function
University of Göttingen
2012-2025
Universitätsmedizin Göttingen
2013-2024
Städtisches Klinikum Karlsruhe
2023-2024
German Primate Center
2016
German Centre for Cardiovascular Research
2012-2014
Abstract CA19-9 values are regularly measured in patients with pancreatic cancer. Certainly, its potential as a biomarker has been compromised by false negative results and positive benign pancreatico-biliary diseases. For detection of PDAC recurrence, however, might play an important role. The aim this study is to analyze the accuracy for detecting recurrence All included were treated either at University Medical Center Goettingen, or Department Interdisciplinary Oncology Pneumonology,...
We explored the use of highly purified murine and human pluripotent stem cell (PSC)-derived cardiomyocytes (CMs) to generate functional bioartificial cardiac tissue (BCT) investigated role fibroblasts, ascorbic acid (AA), mechanical stimuli on formation, maturation, functionality. Murine embryonic/induced PSC-derived CMs were genetically enriched three-dimensional CM aggregates, termed bodies (CBs). Addressing critical limitation major loss after single-cell dissociation, non-dissociated CBs...
Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific use in disease modelling, drug screening, and regenerative medicine. The aim this study was to compare human-induced (hiPSCs) derived from different somatic cell sources regarding their efficiency cardiac differentiation potential, functionalities cardiomyocytes. We generated hiPSCs hair keratinocytes, bone marrow mesenchymal (MSCs), skin fibroblasts by using two virus systems. show...
Significance Nucleic acids mediate storage and expression of genetic information. Extracellular DNA (exDNA) exRNA are traces nucleic released from cells into the extracellular environment. Their use as disease biomarkers has been limited by technical challenges in their isolation caused abundant RNA- DNA-degrading enzymes biofluids. Using protocols developed especially for biofluids, we generated plasma serum reference profiles 13 healthy volunteers over time determined effect critical...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and largely refractory to available treatments. Identifying key pathways associated with disease aggressiveness therapeutic resistance may characterize candidate targets improve patient outcomes. We used strategy of examining the tumors from subset PDAC cohorts worst survival understand underlying mechanisms aggressive progression identify molecular potential significance. Non-negative matrix factorization (NMF) clustering, using...
Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes: classical/progenitor and basal-like/squamous. Our study aimed to identify genes contributing the development of basal-like/squamous subtype, known for its aggressiveness. Transcriptome analyses revealed consistent upregulation SERPINB3 in PDAC, correlating with reduced patient survival. transgene expression PDAC cells enhanced vitro invasion promoted lung metastasis a mouse xenograft model. Metabolome unveiled...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy and refractory to available treatments. Delineating the regulatory mechanisms of metabolic reprogramming, key event in pancreatic cancer progression, may identify candidate targets with potential therapeutic significance. We hypothesized that inflammatory signaling pathways regulate adaptations cancer. Metabolic profiling tumors from PDAC patients high‐ (>median, n = 31) low‐NOS2 (inducible nitric oxide synthase; <median,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) encompasses diverse molecular subtypes, including the classical/progenitor and basal-like/squamous each exhibiting distinct characteristics, with latter known for its aggressiveness. We employed an integrative approach combining transcriptome metabolome analyses to pinpoint potential genes contributing subtype differentiation. Applying this our NCI-UMD-German a validation cohort, we identified LIM Domain Only 3 (LMO3), transcription co-factor,...
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome metabolome approaches can identify candidate genes whose inactivation contributes to the development of aggressive subtype. Using our integrated approach, we identified endosome-lysosome associated apoptosis autophagy regulator 1 (ELAPOR1/KIAA1324) tumor suppressor in both...
Background: Postoperative liver failure (PLF) is a severe complication after major resection (MLR). To increase the safety of patients, clinical bedside tests are great importance. However, limitations their applicability and validity impair value. Methods: Preoperative measurements maximum capacity (LiMAx) were performed in n = 40 who underwent MLR (≥3 segments). Matched postoperative LiMAx was measured 21 patients. Liver function compared between pretreated patients (n 11 with portal vein...
Inflammation and aberrant cellular metabolism are widely recognized as hallmarks of cancer. In pancreatic ductal adenocarcinoma (PDAC), inflammatory signaling metabolic reprogramming tightly interwoven, playing pivotal roles in the pathogenesis progression disease. However, regulatory functions mediators cancer have not been fully explored. Earlier, we demonstrated that pro-inflammatory mediator macrophage migration inhibitory factor (MIF) enhances disease by inhibiting its downstream...
Abstract Pancreatic ductal adenocarcinoma (PDAC) manifests diverse molecular subtypes, including the classical/progenitor and basal-like/squamous with latter known for its aggressiveness. We employed integrative transcriptome metabolome analyses to identify potential genes contributing subtype differentiation metabolic features. Our comprehensive analysis revealed that adrenoceptor alpha 2A (ADRA2A) was downregulated in subtype, suggesting role as a candidate suppressor of this subtype....
Introduction Anti-EGFR targeted therapy is of increasing importance in advanced colorectal cancer and prior KRAS mutation testing mandatory for therapy. However, at which occasions this should be performed still under debate. We aimed to assess patients with locally rectal whether there intra-specimen heterogeneity upon preoperative chemoradiotherapy (CRT), if are any changes status due intervention. Materials Methods analyses were 199 tumor samples from 47 cancer. To evaluate the between...
Background: Patients with locally advanced rectal cancer are treated preoperative chemoradiotherapy followed by surgical resection. Despite similar clinical parameters (uT2-3, uN+) and standard therapy, patients’ prognoses differ widely. A possible prediction of prognosis through microRNAs as biomarkers out treatment-naïve biopsies would allow individualized therapy options. Methods: Microarray analysis 45 microdissected from patients was performed to identify potential predict overall...
<h3>Importance</h3> New-onset postoperative arrhythmia, which most often presents as atrial fibrillation (AF), is a frequent complication in patients undergoing visceral surgery of the upper gastrointestinal tract. Its relevance for patients' outcomes unknown. <h3>Objective</h3> To assess incidence arrhythmia after surgery, its risk factors, and short- long-term implications patient outcomes. <h3>Design, Setting, Participants</h3> This cohort study included 1210 who underwent tract...
The Esophagectomy Complications Consensus Group (ECCG) and the Dutch Upper Gastrointestinal Cancer Audit (DUCA) have set standards in reporting outcomes after oesophagectomy. Reporting from selected high-volume centres or centralized national cancer programmes may not, however, be reflective of true global prevalence complications. This study aimed to compare complication rates oesophagectomy these existing sources with those an unselected international cohort Oesophago-Gastric Anastomosis...
Abstract Purpose Preoperative (neoadjuvant) chemoradiotherapy (CRT) and total mesorectal excision is the standard treatment for rectal cancer patients (UICC stage II/III). Up to one-third of treated with CRT achieve a pathological complete response (pCR). These could be spared from surgery its associated morbidity mortality, assigned “watch wait” strategy. However, reliably identifying pCR based on clinical or imaging parameters remains challenging. Experimental design We generated...
Abstract Postoperative arrhythmias (PAs) are common events and have been widely investigated in cardiothoracic surgery. Within visceral surgery, a recent study revealed significant occurrence of PA esophageal resections. In contrast, lower gastrointestinal surgery is rarely has rudimentary described the medical literature. The present work retrospective cohort 1171 patients who underwent tract between 2012 2018. All included were treated monitored intensive care unit (ICU) or intermediate...
Since the response to chemoradiotherapy in patients with locally advanced rectal cancer is heterogeneous, valid biomarkers are needed monitor tumor response. Circulating microRNAs promising candidates, however analyses of circulating still rare. 111 and 46 age-matched normal controls were enrolled. The expression levels 30 analyzed 17 pre-treatment patients’ plasma samples. Differentially regulated validated 94 independent patients. For 52 a paired comparison between post-treatment samples...