A5103171740- Monoclonal and Polyclonal Antibodies Research
- Cardiac Valve Diseases and Treatments
- T-cell and B-cell Immunology
- Blood Pressure and Hypertension Studies
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Sodium Intake and Health
- Transplantation: Methods and Outcomes
- Cardiac Arrhythmias and Treatments
- Neurobiology and Insect Physiology Research
- Cardiac Imaging and Diagnostics
- Immunotherapy and Immune Responses
- Renal and Vascular Pathologies
- Immunodeficiency and Autoimmune Disorders
- Rheumatoid Arthritis Research and Therapies
- Heart Failure Treatment and Management
- CAR-T cell therapy research
- Blood groups and transfusion
- Business Process Modeling and Analysis
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Immune Cell Function and Interaction
University Hospital Augsburg
2025
Johannes Kepler University of Linz
2014-2024
Leeds Teaching Hospitals NHS Trust
2022
University of Leeds
2022
Kepler Universitätsklinikum
2017-2022
European Society of Cardiology
2022
Heinrich Heine University Düsseldorf
2021
Düsseldorf University Hospital
2021
Osnabrück University
2021
Medical University of Vienna
2008-2021
We present the first three-dimensional map of antennal lobe Drosophila melanogaster, based on confocal microscopic analysis glomeruli stained with neuropil-specific monoclonal antibody nc82. The stacks allowed us to identify according criteria shape, size, position, and intensity labeling. Forty were labeled by nc82, eight which have not been described before. Three previously shown exclusively backfills discernible in nc82 stainings. distinguish three classes glomeruli: (1) "landmark" that...
Sodium-glucose co-transporter 2 inhibition reduces the risk of hospitalization for heart failure and death in patients with symptomatic failure. However, trials investigating effects this drug class following acute myocardial infarction are lacking.
Recent experimental and clinical data point to the T helper lymphocyte subset as playing a central role in pathogenesis of rheumatoid arthritis (RA). Thus, therapeutic strategy aimed specifically at CD4 cell is warranted. We treated patients with active RA for 7 days daily dose 20 mg monoclonal antibody M-T151, administered intravenously over 30 minutes. There were no negative side effects. According changes combined parameters Ritchie articular index, pain assessment, grip strength, morning...
ABSTRACT The final step of pattern formation in the developing retina Drosophila is elimination excess cells between ommatidia and differentiation remaining into secondary tertiary pigment cells. Temporally spatially highly regulated expression irregular chiasmC-roughest protein, an adhesion molecule immunoglobulin superfamily known to be involved axonal pathfinding, essential for correct sorting cell-cell contacts pupal without which ensuing wave apoptosis does not occur. Irregular...
Abstract Objective. To investigate the effects of chimeric CD4 monoclonal antibody cM‐T412 treatment in patients with rheumatoid arthritis (RA). Methods. Thirty‐two RA received daily doses 10, 50, or 100 mg intravenously for 7 days. Results. There was a sustained decrease number CD4+ T lymphocytes all patients. Those who 50 and experienced significant reductions disease activity. Conclusion. Treatment appears to have dose‐dependent beneficial effect The clinical are independent depressed...
We have conducted the first study to determine diagnostic potential of CD14++CD16+ intermediate monocytes as compared pro-angiogenic subset CD14++CD16+TIE2+ TIE2-expressing (TEMs) in cancer. These monocyte populations were investigated by flow cytometry healthy volunteers (N = 32) and colorectal carcinoma patients with localized 24) or metastatic 37) disease. further determined blood levels cytokines associated regulation. The results revealed be significantly elevated cancer show highest...
Two years since the outbreak of novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome 2) pandemic, there remain few clinically effective drugs to complement vaccines. One is anticoagulant, heparin, which in 2004 was found able inhibit invasion SARS-CoV (CoV-1) and has been employed during current pandemic prevent thromboembolic complications moderate potentially damaging inflammation. Heparin also shown experimentally attachment infection susceptible cells. At high therapeutic...
As in vivo real-life data are still scarce, we conducted a study to assess the safety and feasibility of cardiac magnetic resonance imaging (MRI) patients with leadless pacemaker system.In this prospective non-randomized interventional trial, enrolled 15 an MRI conditional Micra® system undergo either 1.5 T or 3.0 scan. Clinical adverse events as well device parameters such pacing threshold, sensing, impedance, battery life were assessed at baseline 1 3 months after Device parameter changes...
Soluble ST2 (sST2) has been introduced as a novel biomarker in patients suffering from heart failure for risk stratification. In this study, we sought to investigate whether sST2 is useful stratification and prediction of mortality undergoing transcatheter aortic valve implantation (TAVI).A total 274 TAVI were included study (149 female; age 81 ± 1 years; EUROSCORE 25 1; STS score 3·8 0·2). Plasma samples obtained preinterventional analysed sST2. Patients followed up month year after TAVI.In...
To use quality indicators to study the management of ST-segment elevation myocardial infarction (STEMI) in different regions.Prospective cohort STEMI within 24 h symptom onset (11 462 patients, 196 centres, 26 European Society Cardiology members, and 3 affiliated countries). The median delay between arrival at a percutaneous cardiovascular intervention (PCI) centre primary PCI was 40 min (interquartile range 20-74) with 65.8% receiving guideline recommendation 60 min. A third patients...
Human B-lymphocytes were fused with the human lymphoblastoid B-cell line WI-L2-729 HF2. Hybridoma frequencies in range of 10-5 when mononuclear cells (a) prestimulated pokeweed mitogen (PWM), (b) polyethyleneglycol (PEG), and (c) selected a hypoxanthine-azaserin (HAza) containing medium. To generate monoclonal antibodies (MAb) specific for tetanus toxin (TToxin) spleen precultured PWM plus toxoid (TToxoid) two separate fusions. Two hybridomas based on high binding activity using an...
A recently introduced method to determine the postmortem interval (PMI) based on quantification of citrate content in bone was applied temporal bones and femora 20 individuals buried wooden coffins (WO) body bags (BB), respectively. Concerning known vs. calculated PMI, a significant difference between femur samples same observed BB group (p = 0.012). In contrast, differences were insignificant for WO 0.400). Moreover, similar levels underestimation PMIs resulted from analysis both burial...