A5104622931- Metabolomics and Mass Spectrometry Studies
- GABA and Rice Research
- Protein Hydrolysis and Bioactive Peptides
- Adipose Tissue and Metabolism
- Advanced Chemical Sensor Technologies
- Cancer, Hypoxia, and Metabolism
- Meat and Animal Product Quality
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Tea Polyphenols and Effects
- Biochemical Analysis and Sensing Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Lipids, and Metabolism
- Nanocomposite Films for Food Packaging
- Sirtuins and Resveratrol in Medicine
- Metabolism, Diabetes, and Cancer
- Seed and Plant Biochemistry
- Lung Cancer Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Muscle metabolism and nutrition
- Microbial Metabolism and Applications
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Insect Resistance and Genetics
- Food composition and properties
St. Boniface Hospital
2016-2024
University of Manitoba
2016-2024
Although pulses are nutritious foods containing high amounts of protein, fiber and phytochemicals, their consumption use in the food industry have been limited due to formation unappealing flavors/aromas described as beany, green, grassy. Lipoxygenase (LOX) enzymes prevalent among pulse seeds, activity can lead specific volatile organic compounds (VOCs) from certain polyunsaturated fatty acids (PUFAs). As a widespread issue legumes, including soybean, these VOCs linked taste perception...
Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) animal models type 1 2 diabetes. We hypothesized that sub-optimal insulin-like (IGF-1) signaling diabetes drives loss AMPK function, both contributing development DSPN. Age-matched control Sprague-Dawley rats...
Abstract Pulses are known to be nutritious foods but susceptible oxidation due the reaction of lipoxygenase (LOX) with linolenic and linoleic acids which can lead off flavors caused by formation volatile organic compounds (VOCs). Infrared micronization at 130 150 °C was investigated as a heat treatment determine its effect on LOX activity VOCs chickpea green lentil flour. The pulse flours were added low‐fat beef burgers 6% measured for consumer acceptability physicochemical properties....
Metabolic alterations in malignant cells play a vital role tumor initiation, proliferation, and metastasis. Biofluids from patients with non–small cell lung cancer (NSCLC) harbor metabolic biomarkers potential clinical applications. In this study, we assessed the changes profile of early-stage NSCLC using mass spectrometry nuclear magnetic resonance spectroscopy before after surgical resection. A single cohort 35 provided total 29 32 pairs urine serum samples, respectively, pre-and...
Abstract Yellow pea ( Pisumsativum L.) is an economically rich source of nutrients with health‐promoting effects. However, the consumption ingredients minimal due to their off‐flavor characteristics. The present study investigated effect Revtech heat treatment on chemical profile and volatile compounds in split yellow flour. (RT) was applied at 140°C a residence time 4 min dry condition (RT 0%) presence 10% steam 10%). Both thermal treatments resulted significant reduction p < 0.05)...
Metabolomics analysis of blood from patients (n = 42) undergoing surgery for suspected lung cancer was performed in this study. Venous and arterial collected both Streck Heparin tubes. A total 96 metabolites were detected, affected by sex 56), collection tube 33), location 8). These belonged to a wide array compound classes including lipids, acids, pharmaceutical agents, signalling molecules, vitamins, among others. Phospholipids carboxylic acids accounted 28% all detected compounds. Out the...
Every year, close to two million people world-wide are diagnosed with and die of lung cancer. Most patients present advanced-stage cancer limited curative options poor prognosis. Diagnosis at an early stage provides the best chance for a cure. Low- dose CT screening chest in high-risk population is current standard care detection However, invasive due radiation exposure carries risk unnecessary biopsies non-cancerous tumors. In this pilot study, we metabolic alterations observed sputum...
Previous studies indicated that North American wild rice (WIR) reduced atherosclerosis and vascular inflammation in low-density lipoprotein receptor knockout mice. The effects of WIR on hyperglycemia diabetic animal models have not been documented. present study aims to determine the impact glucose metabolism high-fat (HF)-induced mice a key modulator. Male C57 BL/J6 were treated with control diet HF supplemented 26% (weight/weight, substitute for carbohydrates diet) or white (WHR) (n =...
Saskatoon berries are grown in Canada and some northwestern states the United States, notable for containing abundant antioxidant polyphenols, vitamins, metal elements, fiber. To increase consumer interest accessibility to berries, producers have begun develop processes refining into a powder with an extended shelf life that can be incorporated variety of value-added food products. assess desirability this approach, study sought determine how sensory attributes, acceptability, volatile...