A5029442092- Pain Mechanisms and Treatments
- Cannabis and Cannabinoid Research
- Pharmacology and Obesity Treatment
- Biochemical effects in animals
- Neurotransmitter Receptor Influence on Behavior
- Neuropeptides and Animal Physiology
- Botulinum Toxin and Related Neurological Disorders
- Pancreatic function and diabetes
- Veterinary Pharmacology and Anesthesia
- Forensic Toxicology and Drug Analysis
- Advanced Glycation End Products research
- Diet, Metabolism, and Disease
- Vanadium and Halogenation Chemistry
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Olfactory and Sensory Function Studies
- Ion Channels and Receptors
- Metabolism, Diabetes, and Cancer
- Advancements in Transdermal Drug Delivery
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Ocular Surface and Contact Lens
- Pain Management and Treatment
- Health and Lifestyle Studies
- Herbal Medicine Research Studies
Indiana University Bloomington
2025
Universidade Federal do Paraná
2012-2024
Indiana University
2024
University of California, San Diego
2018-2022
Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed investigate the potential antinociceptive effect of CBD over mechanical allodynia streptozotocin-induced (DBT) rats, as well its involved mechanisms. Wistar adult male rats were treated acutely or sub-chronically (for 14 days) with (0.1, 0.3 3 mg/kg, intraperitoneal; i.p.) had...
Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) animal models type 1 2 diabetes. We hypothesized that sub-optimal insulin-like (IGF-1) signaling diabetes drives loss AMPK function, both contributing development DSPN. Age-matched control Sprague-Dawley rats...
Abstract Bixin is the main natural apocarotenoid extracted from seeds of Bixa orellana, widely used as a cosmetic and textile colorant. Despite description several pharmacological properties B. orellana extracts, little has been studied regarding bixin. Then we aimed to investigate potential anti-inflammatory antinociceptive effect bixin in preclinical models inflammation acute pain. The activity (15 or 30 mg/kg, orally) was determined using carrageenan-induced paw edema myeloperoxidase...
Diabetic neuropathies are the most prevalent chronic complications of diabetes, characterized by pain and substantial morbidity. Although many drugs have been approved for treatment this type pain, including gabapentin, tramadol (TMD), classical opioids, it is common to report short-term results or potentially severe side effects. TMD, recommended as a second-line can lead unwanted Cannabidiol (CBD) has gaining attention recently due its therapeutic properties, management. This study aimed...
Abstract Opioid use disorder (OUD) is a public health problem that includes symptoms such as withdrawal syndrome and opioid-induced hyperalgesia (OIH). Currently, drugs to treat side effects of opioids also have undesirable effects, which lead limitations. This study investigated the effect treatment with cannabidiol (CBD) in morphine-induced signs morphine-dependent rats. Male female rats were submitted physical dependence protocol consisting twice daily morphine (7.89 mg/kg, 1ml/kg, s.c.)...
Diabetes is a chronic disease associated with high number of complications such as peripheral neuropathy, which causes sensorial disturbances and may lead to the development diabetic neuropathic pain (DNP). The current treatment for DNP just palliative drugs cause severe adverse effects, leading discontinuation treatment. Thus, new therapeutic targets need be urgently investigated. Studies have shown that cannabinoids promising effects in several pathological conditions, including pain. we...
Opioid use disorder is a public health problem that includes symptoms such as withdrawal syndrome and opioid-induced hyperalgesia. Currently, drugs to treat side effects of opioids also have undesirable effects, which lead limitations. This study investigated the effect treatment with cannabidiol in morphine-induced hyperalgesia behavior morphine-dependent rats. Male female rats were submitted physical dependence protocol consisting twice daily morphine (filtered solution, dose 7.89 mg/kg, 1...
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement transmission represents a potential analgesic strategy. However, therapeutic current GABA agonists and modulators limited by unwanted side effects. We postulated that GABA’s degradation enzyme, aminotransferase (GABA-AT), would increase endogenous levels produce analgesia. evaluated antinociceptive efficacy the potent GABA-AT inhibitor OV329 in rodent models neuropathic inflammatory pain...
Corneal confocal microscopy (CCM) is emerging as a tool for identifying small fiber neuropathy in both peripheral neuropathies and neurodegenerative disease of the central nervous system (CNS). The value corneal nerves biomarkers efficacy clinical interventions against less clear but may be supported by preclinical studies investigational agents. We, therefore, used diverse agents to assess concordance nerve loss mouse model diabetes. Ocular delivery peptides ciliary neurotrophic factor...
Neuropathic pain (NP) affects more than 8% of the global population. The proposed action transient receptor potential ankyrin 1 (TRPA1) as a mechanosensor and characterization melastatin 8 (TRPM8) cold thermosensor raises question whether these receptors are implicated in NP. Our study aimed to evaluate involvement TRPA1 TRPM8 mechanical signal transduction obtain comparative view rat models streptozotocin-induced diabetes (STZ) chronic constriction injury sciatic nerve (CCI). electronic von...