A5101512496- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- RNA Research and Splicing
- Cannabis and Cannabinoid Research
- Bladder and Urothelial Cancer Treatments
- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Ferroptosis and cancer prognosis
- Pharmacological Receptor Mechanisms and Effects
- Cancer, Hypoxia, and Metabolism
- Management of metastatic bone disease
- Antimicrobial Peptides and Activities
- Kruppel-like factors research
- NF-κB Signaling Pathways
- Bone health and treatments
- Chemokine receptors and signaling
- Circular RNAs in diseases
- PARP inhibition in cancer therapy
Zhejiang Chinese Medical University
2018-2024
Indiana University
2024
Indiana University Bloomington
2012-2022
Zhejiang Provincial Hospital of TCM
2022
Nanjing University of Chinese Medicine
2021-2022
Jiangyin People's Hospital
2021
First Affiliated Hospital of Anhui Medical University
2019
Anhui Medical University
2019
Second Hospital of Anhui Medical University
2019
Fourth Hospital of Hebei Medical University
2016-2018
Painful peripheral neuropathy is a common neurological complication associated with human immunodeficiency virus (HIV) infection and anti-retroviral therapy. We characterized the impact of two CB2 cannabinoid agonists (AM1710 LY2828360 – ligands differing in signaling bias CNS penetration) on neuropathic nociception induced by antiretroviral agent Zalcitabine (2',3'-dideoxycytidine; ddC). also used conditional knockout approach to identify cell types mediating agonist-induced antinociceptive...
Abstract CB 2 cannabinoid receptors (CB ) are a promising therapeutic target that lacks unwanted side effects of 1 activation. However, the cell types expressing mediate these remain poorly understood. We used transgenic mice with promoter–driven expression enhanced green fluorescent protein (EGFP) to study express and suppress neuropathic nociception in mouse model chemotherapy-induced peripheral neuropathy. Structurally distinct agonists (AM1710 LY2828360) suppressed paclitaxel-induced...
<i>Objective:</i> The aim of this study is to investigate the molecular mechanism hepatocellular carcinoma (HCC) development induced by hepatitis B virus X protein (HBx). <i>Methods:</i> We previously established a H7402-X cell line that constitutively expresses HBx protein. In present study, gene expression profiles and proteins were examined using cDNA microarrays Western blot analysis. Apoptosis was adriamycin in cells. transcriptional activities NF-ĸB AP-1...
Background. ANLN and miR-30a-5p may be involved in the progression of lung adenocarcinoma (LUAD). However, their underlying mechanism LUAD has not been completely comprehended. Methods. Differential expression analysis, binding site prediction, survival analysis were conducted by bioinformatics approaches. mRNA detected qRT-PCR. protein was western blot. Cell behaviors examined functional experiments. Results. activated cells terms protein. High level positively correlated with poor...
Rapid and accurate assembly of the ribosomal subunits, which are responsible for protein synthesis, is required to sustain cell growth. Our best understanding interaction 30S subunit components (16S RNA [rRNA] 20 proteins [r-proteins]) comes from in vitro work using Escherichia coli components. However, detailed information regarding essential elements involved subunits still remains elusive. Here, we defined a set rRNA nucleotides that critical small E. . Using an modification interference...
The objective of the present study was to investigate association B7-H3 expression and cluster differentiation (CD)163+ tumor-associated macrophage (TAM) infiltration with clinicopathological parameters in urothelial cell carcinoma bladder (UCB), their potential conjoint effects on progression UCB. CD163+ TAM tumor specimens from 134 consecutive patients that underwent radical cystectomy for UCB were tested using immunohistochemistry, followed by statistical analysis. In these patients,...
Abstract Background Lung adenocarcinoma (LUAD) is one of the leading contributors to cancer‐related deaths worldwide. The objective current study identify a multidimensional transcriptome prognostic signature by combining protein‐coding gene (PCG) with long non‐coding RNA (lncRNA) for patients LUAD. Methods We obtained LUAD PCG and lncRNA expression profile data from three datasets in Gene Expression Omnibus database conducted survival analyzes these individuals. Results established...
Introduction: Rectal cancer ranks as the eighth in cancer-related morbidity and tenth mortality. A few studies have explored several biomarkers for colorectal cancer. However, there is still a great need us to excavate novel with effective efficient diagnostic prognostic values discover etiology pathogenesis of rectal separately. Therefore, we aimed identify more candidate genes that were significantly associated through integrated bioinformatics analysis. Methods: We analyzed gene...
One of the 60 or so genes conserved in all domains life is ksgA/dim1 orthologous group. Enzymes from this family perform same post-transcriptional nucleotide modification ribosome biogenesis, irrespective organism. Despite common function, divergence has enabled some members to adopt new and sometimes radically different functions. For example, S. cerevisiae Dim1 performs two distinct functions while human mtTFB not only an rRNA methyltransferase mitochondria but also a mitochondrial...
This study aims at screening out the key necroptosis-related genes in colorectal cancer and elucidating role of immune activity prognosis (CRC). The CRC patients’ data were downloaded from Cancer Genome Atlas (TCGA). non-negative matrix factorization method was applied to identify new molecular subgroups . Survival analysis single sample Gene Set Enrichment Analysis performed determinate differences overall survival time status subgroups. Prognostic model constructed on basis univariate Cox...
Brome mosaic virus (BMV) is a model positive-strand RNA whose replication has been studied in number of surrogate hosts. In transiently transfected human cells, the BMV polymerase 2a activated signaling by innate immune receptor RIG-I, which recognizes de novo-initiated non-self-RNAs. Active-site mutations abolished RIG-I activation, and coexpression 1a protein stimulated activity. Mutations previously shown to abolish interaction prevented 1a-dependent enhancement New insights into 1a-2a...
Dysregulation of GABAergic inhibition is associated with pathological pain. Consequently, enhancement transmission represents a potential analgesic strategy. However, therapeutic current GABA agonists and modulators limited by unwanted side effects. We postulated that GABA’s degradation enzyme, aminotransferase (GABA-AT), would increase endogenous levels produce analgesia. evaluated antinociceptive efficacy the potent GABA-AT inhibitor OV329 in rodent models neuropathic inflammatory pain...
Small cell lung cancer (SCLC) is a highly invasive and fatal malignancy. Research at the present stage implied that expression of immune-related genes associated with prognosis in SCLC. Accordingly, it essential to explore effective molecular markers judge treat Our research obtained SCLC dataset from Gene Expression Omnibus (GEO) subjected mRNAs differential analysis. Differentially expressed (DEmRNAs) were intersected yield differentially (DEGs). The functions these DEGs revealed by...
Objective To investigate the expression of B7-H3 and infiltration by CD68+ tumor-associated macrophages (TAMs) in urothelial cell carcinoma (UCC) bladder evaluate its potential prognostic significance for cancer. Methods Data from 76 consecutive UCC patients (63 males 13 females), median age 65.5 years(ranging 41 to 86 years), who underwent radical cystectomy, was collected. Immunohistochemistry TAMs performed on tumor tissues explore their association with clinicopathologic features...