A5067638774- Peripheral Neuropathies and Disorders
- Hereditary Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Neurodegenerative Diseases
- Diabetic Foot Ulcer Assessment and Management
- Myasthenia Gravis and Thymoma
- Neurotransmitter Receptor Influence on Behavior
- Acute Ischemic Stroke Management
- Autoimmune Neurological Disorders and Treatments
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Neurofibromatosis and Schwannoma Cases
- Neurogenesis and neuroplasticity mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Musculoskeletal pain and rehabilitation
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Peripheral Nerve Disorders
- Autoimmune and Inflammatory Disorders Research
- Bipolar Disorder and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Inflammasome and immune disorders
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2017-2024
University of California, San Diego
2018-2021
Second Military Medical University
1999-2015
Changhai Hospital
2015
Eastern Hepatobiliary Surgery Hospital
1999
Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) animal models type 1 2 diabetes. We hypothesized that sub-optimal insulin-like (IGF-1) signaling diabetes drives loss AMPK function, both contributing development DSPN. Age-matched control Sprague-Dawley rats...
Purpose: To investigate the risk factors associated with subclinical diabetic peripheral neuropathy (sDPN) in patients type 2 diabetes mellitus (T2DM). Patients and Methods: This cross-sectional, retrospective study involved 311 T2DM who were successively admitted from January 2018 to December 2021 without any neurological symptoms. All participants underwent a nerve conduction (NCS), those asymptomatic abnormal diagnosed sDPN. Differences between groups evaluated by chi-squared, Wilcoxon,...
Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated (htau mice), we assessed the contribution to peripheral central neurodegeneration. Indices small large fiber neuropathy learning memory performances were at 3 6 months age. Overexpression associated with Our study also provides evidence that hyperphosphorylation plays critical role in deficits. In addition, htau had...
Impaired rate-dependent depression (RDD) of the spinal H-reflex occurs in diabetic rodents and a sub-set patients with painful neuropathy. RDD is unaffected animal models neuropathy associated peripheral pain mechanisms painless neuropathy, suggesting could serve as biomarker for individuals whom disinhibition contributes to help identify therapies that target impaired inhibitory function. The pharmacology was investigated normal rats after 4 8 weeks streptozotocin-induced diabetes. In rats,...
Background: The relationship between serum low-density lipoprotein cholesterol (LDL-C) and the risk of relapse in neuromyelitis optica spectrum disorder (NMOSD) remains uncertain. We aimed to examine association LDL-C level NMOSD patients. Methods: conducted an analysis prospective observational cohort study with consecutive 184 hospitalized patients from department neurology. Blood samples were collected measure upon admission. Primary evaluated during hospitalization. analyzed by linear...
We investigated the application of rate-dependent depression (RDD) Hoffmann (H) wave as a predictor treatment efficacy in patients with painful diabetic peripheral neuropathy (DPN). General medical information, scales, and nerve conduction data were collected from 73 healthy subjects, 50 subjects type 2 diabetes painless DPN, 71 DPN. The left tibial was stimulated, RDD calculated by decline amplitude third H relative to first one. Gabapentin initiated after baseline evaluation, visual analog...
Abstract Introduction The relationship between peripheral 5‐ HT 3A receptor mRNA level and risperidone efficiency in paranoid schizophrenia patients is still unknown. Methods A total 52 first‐episode drug‐naive who were treated with 53 matched healthy controls enrolled. Patients naturalistically followed up for 8 weeks. Positive Negative Syndrome Scale ( PANSS ) was applied to assess symptom severity of the at baseline end 8th week. Results There no difference p = .24). Among 47 completed...
Cell-based assays (CBAs) and radioimmunoprecipitation assay (RIPA) are the most sensitive methods for identifying anti-acetylcholine receptor (AChR) antibody in myasthenia gravis (MG). But CBAs limited clinical practice by transient transfection. We established a stable cell line (KL525) expressing clustered AChR infecting HEK 293T cells with dual lentiviral vectors genes encoding human α1, β1, δ, ϵ clustering protein rapsyn. verified expression of immunofluorescence, immunoblotting,...
Objective: Elevated low-density lipoprotein cholesterol (LDL-C) is an established risk factor for ischemic stroke; however, whether LDL-C affects the platelet deformation function in peripheral blood circulation patients with acute stroke (AIS) unknown. The present study aimed to investigate relationship between and distribution width (PDW) AIS patients. Methods: We conducted a cross-sectional hospitalized-based of consecutive 438 within 24 h. Blood samples were collected upon admission...
POEMS syndrome is a rare multisystem disorder associated with the clinical signs of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes. However, there often delay in diagnosis due to lack overall consideration symptoms collectively. For this reason, frequently mistaken for other diseases, such as chronic inflammatory demyelinating polyneuropathy. The present study reports case 40-year-old female patient, who presented progressive strength lower limbs...