A5101670187- Neurogenesis and neuroplasticity mechanisms
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Multiple Sclerosis Research Studies
- Phytochemistry and Biological Activities
- Medicinal Plants and Bioactive Compounds
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Sphingolipid Metabolism and Signaling
- Flavonoids in Medical Research
- Circadian rhythm and melatonin
- Metabolism, Diabetes, and Cancer
- Redox biology and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Extracellular vesicles in disease
- Galectins and Cancer Biology
- Circular RNAs in diseases
- Essential Oils and Antimicrobial Activity
- Neuropeptides and Animal Physiology
- Cryospheric studies and observations
- Geological Studies and Exploration
Shaanxi Normal University
2009-2025
Thomas Jefferson University
2015-2022
China XD Group (China)
2018
Natural compounds derived from medicinal plants have long been considered a rich source of novel therapeutic agents. Baicalin (Ba) is bioactive flavonoid compound the root Scutellaria baicalensis, an herb widely used in traditional medicine for treatment various inflammatory diseases. In this study, we investigate effects and mechanism action Ba experimental autoimmune encephalomyelitis (EAE), animal model multiple sclerosis (MS). effectively ameliorated clinical disease severity myelin...
MicroRNAs (miRNAs) are small, non-coding RNAs involved in immune response regulation. Specific miRNAs have been linked to the development of various autoimmune diseases; however, their contribution modulation CNS-directed cellular infiltration remains unclear. In this study, we found that miR-23b, addition its reported functions suppression IL-17-associated inflammation, halted progression experimental encephalomyelitis (EAE), an animal model multiple sclerosis (MS), by directly inhibiting...
Inflammatory demyelination and axonal damage of the CNS are hallmarks multiple sclerosis (MS) its animal model, experimental autoimmune encephalomyelitis (EAE). Fingolimod (FTY720), first FDA-approved oral medication for MS, suppresses acute disease but is less effective at chronic stage, whether it has a direct effect on neuroregeneration in MS EAE remains unclear. Here we show that FTY720, nanomolar concentrations, effectively protected survival neural stem cells (NSCs) enhanced their...
Myelin injury occurs in brain ageing and several neurological diseases. Failure of spontaneous remyelination is attributable to insufficient differentiation oligodendrocyte precursor cells (OPCs) into mature myelin-forming oligodendrocytes CNS demyelinated lesions. Emerging evidence suggests that peroxisome proliferator-activated receptor γ (PPARγ) the master gatekeeper repair plays an important regulatory role various neurodegenerative Although studies demonstrate positive effects PPARγ...
Abstract The essential oil from the air-dried leaves of Salvia miltiorrhiza Bunge, collected Qinling Mountains China during blooming stage, was obtained by hydrodistillation and analyzed gas chromatography (GC) chromatography/mass spectrometry (GC/MS). Hexadecanoic acid (17.0%), germacrene D (9.1%), phytol (8.9%), β-caryophyllene (7.1%) methyl linolenate (5.3%) were main components (73.3%). showed moderate antibacterial activity against Bacillus coagulans, Staphylococcus albus aureus. sample...
Oligodendrocyte progenitor cells (OPCs) are a subtype of glial responsible for myelin regeneration. Oligodendrocytes (OLGs) originate from OPCs and the myelinating in central nervous system (CNS). OLGs play an important role context lesions which loss occurs. Even though many protocols isolating have been published, their cellular yield remains limit clinical application. The protocol proposed here is novel has practical value; fact, can be generated source autologous without gene...
Iridoid glycosides (CIG) are the major component of Corni fructus. In this work, we researched antioxidative, hypoglycemic and lowering blood lipids effects CIG on diabetic mice induced by a high-fat diet (HFD) streptozotocin (STZ). Furthermore, to investigate molecular mechanism action, phosphorylation protein expression phosphoinositide 3-kinase (PI3K) its downstream proteins, such as insulin receptor (INSR), kinase B (Akt/PKB) glucose transporter 4 (GLUT4) have been detected. The results...
The precipitation in Pamirs Plateau plays a vital role the water resources arid areas of Central Asia. Understanding moisture sources and vapor transportation associated with are very important, but there were few studies investigating Plateau. We used Hybrid Single-Particle Lagrangian Integrated Trajectory model driven high-resolution WRF output to analyze at Northern (NPP) Southern (SPP) spring winter, 2016 2017, as annual largest lowest winter was much higher than that summer autumn. from...