A5110893169- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Complement system in diseases
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Acute Kidney Injury Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Renal and related cancers
- Gout, Hyperuricemia, Uric Acid
- Lipoproteins and Cardiovascular Health
- Chronic Lymphocytic Leukemia Research
- Heart Rate Variability and Autonomic Control
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Multiple Myeloma Research and Treatments
- Ovarian cancer diagnosis and treatment
- Connective Tissue Growth Factor Research
Hôpital du Sacré-Cœur de Montréal
2016-2025
Université de Montréal
2015-2025
Cegep de Saint Jerome
2020-2024
Centre Hospitalier Universitaire Sainte-Justine
2022
Centre hospitalier universitaire de Québec
2020
Université Laval
2020
Research Institute Hospital 12 de Octubre
2019
Pediatric Nephrology of Alabama
2015
Toronto General Hospital
2004-2012
University of Toronto
2009-2012
The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors outcome. Whether it applies to individuals excluded from the original study how therapy influences predictive value pathology remain uncertain. VALIGA examined 1147 patients 13 European countries that encompassed whole spectrum IgAN. Over a median follow-up 4.7...
The Oxford Classification of IgA nephropathy does not account for glomerular crescents. However, studies that reported no independent predictive role crescents on renal outcomes excluded individuals with severe insufficiency. In a large cohort pooled from four retrospective studies, we addressed as predictor and determined whether the fraction crescent-containing glomeruli associates survival either ≥50% decline in eGFR or ESRD (combined event) adjusting covariates used original study. 3096...
Current guidelines suggest treatment with corticosteroids (CS) in IgA nephropathy (IgAN) when proteinuria is persistently ≥1 g/d despite 3–6 months of supportive care and eGFR >50 ml/min per 1.73 m2. Whether the benefits this extend to patients an eGFR≤50 m2, other levels proteinuria, or different renal pathologic lesions remains unknown. We retrospectively studied 1147 IgAN from European Validation Study Oxford Classification (VALIGA) cohort classified according Oxford-MEST classification...
Focal and segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases to terminate in ESRD. A complete remission (CR) confers an excellent long-term prognosis, but quantitative benefits partial remissions (PR) have not been defined. This study evaluated rate renal function decline (slope creatinine clearance) survival nephrotic FSGS patients with CR, PR, or no remission. It also examined relapse from its impact on outcome. Multivariate analysis included clinical...
Summary Background and objectives We assessed the activation of oxidative stress pathway in patients with IgA nephropathy (IgAN), while evaluating classic marker disease (galactose-deficient serum IgA1). Design, setting, participants, & measurements Sera from 292 69 healthy controls Italy United States were assayed for advanced oxidation protein products (AOPPs), free sulfhydryl groups on albumin (SH-Alb), IgA1 galactose-deficient hinge-region O -glycans (Gd-IgA1). Gd-IgA1 was detected...
Abstract Introduction The risk of acute kidney injury (AKI) with the use albumin-containing fluids compared to starches in surgical intensive care setting remains uncertain. We evaluated adjusted AKI associated colloids following cardiac surgery. Methods performed a retrospective cohort study patients undergoing on-pump surgery tertiary center from 2008 2010. assessed crystalloid and colloid administration until 36 hours after was defined by RIFLE (risk, injury, failure, loss end-stage...
Background and objectives: Although early studies suggest that patients with idiopathic membranous nephropathy (MGN) subnephrotic range proteinuria overall do well, these were small follow-up was short or difficult to discern. Design, setting, participants, & measurements: Three hundred ninety-five cases of MGN at least 12 mo from the Toronto Glomerulonephritis Registry reviewed determine outcome subgroup presented proteinuria. Onset data included mean arterial pressure (MAP) creatinine...
ANCA-associated vasculitis (AAV) is treated with potent immunosuppressive regimens. This study sought to determine risk factors associated infections during first-intention therapy.This retrospective involved two separate cohorts of consecutive cases AAV seen from 2004 2011 at university hospitals. The following were assessed: severity; therapy; and periods no, moderate (lymphocyte count, 0.3-1.0× 10(9)/L), or severe count ≤ 0.3×10(9)/L) lymphopenia neutropenia (neutrophil 1.5×10(9)/L).One...
Objective, Design and Patients: The risk of acute kidney injury (AKI) associated with hydroxyethyl starch may be limited to higher molecular weight agents. We retrospectively evaluated the AKI using pentastarch 10% (250 kDa, 0.45) in a random cohort 563 patients operated for cardiac surgery at university hospital. Measures: assessed previously identified preoperative, perioperative, postoperative factors, volume given until end first day. defined by 50% rise serum creatinine within 4 days...
Tonsillectomy has been considered a treatment for IgA nephropathy (IgAN). It is aimed at removing source of pathogens, reducing mucosa-associated lymphoid tissue and decreasing polymeric synthesis. However, its beneficial effect still controversial. In Asia, favorable outcomes have claimed mostly in association with corticosteroids. Europe, small, single-center uncontrolled studies failed to show benefits.The European validation study the Oxford classification IgAN (VALIGA) collected data...
<b><i>Background:</i></b> Recent acute kidney injury (AKI) guidelines, based on studies performed a decade ago, recommend avoiding aminoglycosides (AGs) in patients at risk of AKI. Whether present patient characteristics and management have changed this is uncertain. We determined the current incidence, factors outcomes AG-AKI. <b><i>Methods:</i></b> retrospectively identified adult who received gentamicin or tobramycin for ≥5 days 2 large...
The appropriate observation period, rate and risk factors of complications after a percutaneous renal biopsy remain debated.We retrospectively studied native kidney biopsies performed in our institution between January 2007 July 2011. Outpatients had either an 8- (67%) or 24-hour (33%) period.312 were reviewed (287 patients), 51% patients female the mean age was 54 ± 15 years. Half these outpatients. A total 15% developed symptomatic hematoma, 9% received red blood cell transfusion 1%...