A5064303853- Dialysis and Renal Disease Management
- Liver Disease and Transplantation
- Chronic Kidney Disease and Diabetes
- Parathyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Medication Adherence and Compliance
- Acute Kidney Injury Research
- Renal function and acid-base balance
- Pharmacological Effects and Toxicity Studies
- Liver Disease Diagnosis and Treatment
- Anesthesia and Pain Management
- Diabetes Treatment and Management
- Clinical Reasoning and Diagnostic Skills
- Diabetes Management and Research
- Poisoning and overdose treatments
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Valve Diseases and Treatments
- Bipolar Disorder and Treatment
- Bone health and treatments
- Muscle and Compartmental Disorders
- Potassium and Related Disorders
- Hepatitis Viruses Studies and Epidemiology
- Organ Donation and Transplantation
- Cardiovascular Function and Risk Factors
- Drug-Induced Hepatotoxicity and Protection
Centre Hospitalier de l’Université de Montréal
1998-2022
Université de Montréal
2000-2020
Hôpital Saint-Luc
1991-2015
Hôpital du Sacré-Cœur de Montréal
2011
McGill University
2008
Centre Hospitalier Universitaire Sainte-Justine
1995-1998
University of Ottawa
1998
University of Toronto
1989
Toronto Western Hospital
1987-1989
St. Michael's Hospital
1989
We have previously shown that the Nichols assay for intact parathyroid hormone (I-PTH) reacts with a non-(1-84) molecular form of PTH. This behaves as carboxy-terminal fragment and accumulates in renal failure, accounting 40-60% measured immunoreactivity. wanted to see whether this was common event other commercial two-site I-PTH assays. thus compared ability three kits [Nichols (NL), Incstar (IT), Diagnostic System Laboratories (DSL)] measure 112 failure patients detect hPTH(1-84)...
Abstract Background: The Script Concordance (SC) test is a new assessment tool. It designed to probe whether knowledge of examinees efficiently organized for clinical actions. That kind organization named script. SC places in written, but authentic, situations which they must interpret data make decisions. Purpose: measure the degree concordance that exists between examinees' scripts and panel experts. objective this article provide interested educators with practical "how to" information...
A molecular form of PTH different from PTH-(1-84) and present in normal serum is recognized by two-site intact (I-) assays; it responds to Ca2+ changes the same way that carboxyl-terminal fragments do. To evaluate impact this finding, we have compared basal, stimulated, nonsuppressible I-PTH values 14 subjects 15 renal failure patients, subdivided into 8 patients with low (< 12 pmol/L; LBI) 7 high (> HBI) basal I-PTH. Samples obtained under various calcemic conditions these 3 groups were...
Cardiovascular diseases (CVD) represent a heavy economic burden on individuals, health services, and society. Low adherence to antihypertensive (AH) agents is acknowledged as major contributor the lack of blood pressure control, may have significant impact clinical outcomes healthcare costs.To evaluate low AH cardiovascular hospitalization costs.A cohort 59,647 patients with essential hypertension was reconstructed from Régie de l'assurance maladie du Québec Med-Echo databases. Subjects...
The benefits of antihypertensive (AH) drugs on the risks major cardiovascular outcomes have been demonstrated in clinical trials. However, approximately half hypertensive patients do not adhere well to their prescribed AH therapy actual practice. purpose this study was assess impact adherence agents incidence cerebrovascular disease (CD) real-world practice.A cohort 83 267 reconstructed from Régie de l'assurance maladie du Québec databases. Subjects included were between 45 and 85 years old,...
The appropriate observation period, rate and risk factors of complications after a percutaneous renal biopsy remain debated.We retrospectively studied native kidney biopsies performed in our institution between January 2007 July 2011. Outpatients had either an 8- (67%) or 24-hour (33%) period.312 were reviewed (287 patients), 51% patients female the mean age was 54 ± 15 years. Half these outpatients. A total 15% developed symptomatic hematoma, 9% received red blood cell transfusion 1%...
The progression from acute kidney injury (AKI) to chronic disease (CKD) is not well understood in children.We aimed develop a pediatric CKD definition using administrative data and use it evaluate the association between AKI critically ill children 5 years after hospital discharge.Retrospective cohort study chart collection data.Two-center Montreal, Canada.Children (≤18 old) admitted two intensive care units (ICUs) 2003 2005. We priori excluded patients with end-stage renal or no health...
Commercial intact parathyroid hormone (I-PTH) assays detect molecular form(s) of human PTH, non-(1-84) different from the 84-amino acid native molecule. These accumulate in hemodialyzed patients. We investigated importance PTH interpretation increased I-PTH progressive renal failure.Five groups were studied: 26 healthy individuals, 12 patients, and 31 patients with failure subdivided according to their glomerular filtration rate (GFR) into 11 a GFR between 60 100 mL. min(-1). 1.73 m(-2), 30...
Abstract Background: To separate non-(1–84)parathyroid hormone [non-(1–84)PTH] from PTH(1–84), we developed new HPLC gradients and observed that the peak coeluting with hPTH(1–84) could be separated into two entities recognized by a cyclase-activating PTH (CA-PTH) assay reacts first four amino acids of structure. Methods: Sera six healthy individuals five patients primary hyperparathyroidism, eight pools sera in renal failure were fractionated HPLC. A total (T)-PTH reacting (15–20) region,...
* Non-adherence is probably an important source of preventable cardiovascular morbidity and mortality. However, until now there have been very few large effectiveness studies assessing the relationship between adherence levels to antihypertensive medication major outcomes for primary prevention disease.* The study results suggest that association better agents a relative risk reduction coronary artery disease. Adherence needs be improved so patients can benefit from full protective effects...
Background and objectives Little is known about the long-term burden of AKI in pediatric intensive care unit. We aim to evaluate if associated with higher health service use post–hospital discharge. Design, setting, participants, & measurements This a retrospective cohort study children (≤18 years old) admitted two tertiary centers Montreal, Canada. Only first admission per patient was included. defined ways: serum creatinine alone or and/or urine output. The outcomes were 30-day,...
OBJECTIVES: (1) To evaluate the association between acute kidney injury (AKI) in PICU and long-term mortality (2) to determine extent which adding urine output (UO)–defined AKI alters association. METHODS: A 2-center retrospective cohort study of children (≤18 years old) admitted 2003 2005 for noncardiac surgery, with follow-up until 2010. Patients end stage renal disease, no provincial health insurance number, who died during hospitalization, or could not be linked administrative data were...
OBJECTIVE: Transjugular intrahepatic portosystemic shunt (TIPS) is used increasingly as a treatment for refractory ascites. The aim of the present study was to determine prognostic value different parameters in predicting favorable evolution following TIPS cohort 53 cirrhotic patients without organic renal disease and with METHODS: Patients were classified good responders if they survived more than 6 months, severe chronic hepatic encephalopathy control outcome evaluated using age,...
To assess the contribution of venous effects to hemodynamic changes caused by atrial natriuretic factor (ANF), cardiac and peripheral ANF were compared with those induced venoarterial vasodilator sodium nitroprusside. On 3 different days, eight healthy subjects received 2-hour infusions either ANF, nitroprusside, or placebo, a single-blind crossover design. was administered at rate 15 ng/kg/min for hour 1 50 2; each infusion preceded 50-micrograms bolus. The lower increased plasma cGMP...
Lithium (Li) is a first-line treatment for bipolar disorder but has narrow therapeutic index. Treatment of Li toxicity includes supportive measures and hemodialysis in severe cases, this modality not always immediately available. Sodium polystyrene sulfonate (SPS, Kayexalate), cation exchanger, been promising animal models human reports to reduce absorption enhance elimination Li.A retrospective cohort study was conducted. All cases chronic intoxication were reviewed two adult-care hospitals...
Recent trends in parathyroidectomy rates are not known. Our objective was to investigate the trend between 2001 and 2010, evaluate if availability reimbursement of cinacalcet modified that trend.Using a provincial administrative database, we included all adult patients receiving chronic dialysis treatments 2010 (incident prevalent) time series analysis. The effect on bimonthly modeled using an ARIMA intervention model different cut-off dates: September 2004 (Health Canada approval), January...