A5079062771- Atrial Fibrillation Management and Outcomes
- Pharmaceutical Practices and Patient Outcomes
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- Medication Adherence and Compliance
- Cardiac, Anesthesia and Surgical Outcomes
- Erythropoietin and Anemia Treatment
- Dialysis and Renal Disease Management
- 3D IC and TSV technologies
- Iron Metabolism and Disorders
- Electronic Packaging and Soldering Technologies
- Cardiac Arrhythmias and Treatments
- Pharmaceutical Economics and Policy
- Potassium and Related Disorders
- Cardiovascular Syncope and Autonomic Disorders
- Central Venous Catheters and Hemodialysis
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Vascular Procedures and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Geriatric Care and Nursing Homes
- Chronic Kidney Disease and Diabetes
- Membrane-based Ion Separation Techniques
- Pharmacovigilance and Adverse Drug Reactions
Dalhousie University
2014-2025
Nova Scotia Health Authority
2016-2025
Royal British Legion
2023
Henkel (United States)
2023
St. Francis Xavier University
2023
Capital District Health Authority
2010-2014
Health Sciences Centre
2013
Canadian Society of Nephrology
2013
Queen Elizabeth II Health Sciences Centre
2001-2004
Victoria General Hospital
2001
Data evaluating the safety of using weight-based dosing low-molecular-weight heparin (LMWH) in obese patients are limited. Some manufacturers have recommended a maximum daily dose LMWH not to be exceeded. The purpose this study was determine if body weight influenced anticoagulant response for treatment venous thromboembolism. Patients with serum creatinine levels <150 µmol/l receiving , dalteparin 200 anti-Xa IU/kg based on actual subcutaneously once deep vein thrombosis or pulmonary...
Background: Diabetes is the leading cause of kidney disease and contributes to 38% failure requiring dialysis. A gap in detection management type 2 diabetes (T2D) chronic (CKD) exists primary care. Community pharmacists are positioned support those not able access care through traditional pathways. Algorithms were developed validated assist community identifying individuals with T2D CKD prescribing kidney-protective medications. Objective: The objective was develop validate pharmacist...
Dabigatran etexilate represents a possible improved alternative to warfarin for anticoagulation in hemodialysis patients with atrial fibrillation (AF). The objective was determine dabigatran plasma concentrations and anticoagulant effects following administration of single 110 mg oral dose 10 adult immediately prior starting hemodialysis. Mass spectrometry the Hemoclot® assay were used, respectively, free (unconjugated) thrombin time (TT) samples collected intermittently over 48 hours....
Polypharmacy is ubiquitous in patients on hemodialysis (HD), and increases risk of adverse events, medication interactions, nonadherence, mortality. Appropriately applied deprescribing can potentially minimize polypharmacy risks. Existing guidelines are unsuitable for nephrology clinicians as they lack specific instructions how to deprescribe which safety parameters monitor.To develop validate algorithms nine classes decrease HD.Questionnaires materials sent electronically.Nephrology...
<b><i>Background:</i></b> Calcific uremic arteriolopathy (CUA) is a rare but serious disorder affecting 4% of dialysis patients. Intravenous sodium thiosulfate (IV STS) has been shown as an effective treatment. In Canada, the average cost IV STS about CAD 12,000 per month, while compounded oral 45 month. <b><i>Methods:</i></b> Prospective cohort where all patients diagnosed with CUA during year 2011 were included. They treated initially STS....
Background: Warfarin is an effective agent for prophylaxis against deep-vein thrombosis following total hip or knee arthroplasty. However, management with warfarin in the postoperative setting problematic because of need anticoagulant monitoring. We developed a nomogram dosing that was specific joint The objective this study to compare performance physician-adjusted patients undergoing Methods: involved two cohort trials. historical control group consisted 1024 who underwent arthroplasty...
Background and objectives Evidence to guide hemodialysis catheter locking solutions is limited. We aimed assess effectiveness cost of recombinant tissue plasminogen activator (rt-PA) once per week as a solution, compared with thrice weekly citrate or heparin, in patients at high risk complications. Design, setting, participants, & measurements used prospective design pre-post comparison three sites across Canada. Pre-post comparisons were conducted using multilevel mixed effects...
Ambulatory medication reconciliation can reduce the frequency of discrepancies and may also adverse drug events. Patients receiving dialysis are at high risk for because they typically have multiple comorbid conditions, taking many medications, care from practitioners. Little is known about potential benefits ambulatory these patients.To determine number, type, level harm associated with identified through to ascertain views community pharmacists family physicians this service.This...
Abstract Background The intermediate-term impact of acute kidney injury (AKI) in patients after major gastrointestinal and liver surgery has not been well characterized. This study aimed to evaluate the 1-year mortality rate renal outcomes associated with postoperative AKI a national prospective cohort. Methods multicentre, observational cohort follow-up included adults undergoing across UK Ireland between 23 September 18 November 2015. was defined according Kidney Disease Improving Global...
ABSTRACT Objective: To assess the effectiveness and safety of a hospitalbased perioperative outpatient program for patients at risk thromboembolic complications who require temporary interruption oral anticoagulants dental, surgical, or diagnostic procedures. Methods: A prospective cohort study was performed with consecutive high-risk receiving long-term anticoagulant therapy required surgical procedures during 12-month period. High-risk were defined as those recent recurrent venous...
Background: The kidneys are responsible for the elimination of many drugs. Chronic kidney disease (CKD) is common, and medications may require adjustment to avoid adverse outcomes. Despite availability drug dosing resources, people with CKD at risk inappropriate prescribing. Community pharmacists in ideal position mitigate harm from prescribing this population. Methods: In qualitative study, community were interviewed on their perspective function assessment dose advanced (estimated...
Deprescribing is a patient-centered solution to reducing polypharmacy in patients on hemodialysis (HD). In deprescribing pilot study, were hesitant participate due limited understanding of their own medications and unfamiliarity with the concept deprescribing. Therefore, patient education materials designed address these knowledge gaps can overcome barriers shared decision-making reduce hesitancy regarding deprescribing.To develop validate medication-specific, toolkit (bulletin video) that...
Iron deficiency anemia is common in patients with advanced chronic kidney disease (CKD). Ferric derisomaltose (FDI) enables iron repletion a single dose, unlike other forms of for IV administration, which require multiple doses. Protocols are commonly used irons, but there limited Canadian data FDI, and no protocol exists.To evaluate the efficacy safety FDI CKD to ascertain information related its use provinces.This retrospective cohort study involved non-dialysis-dependent (NDD-CKD)...
ABSTRACT Objective: To evaluate the quality of oral anticoagulant monitoring by means point-of-care testing in a community pharmacy, performed under supervision staff specialized hospital anticoagulation clinic. Methods: Participants consisted patients receiving long-term warfarin therapy who were expected to require treatment for at least 3 months and clinic or customers designated pharmacy. The primary endpoint was proportion time which international normalized ratio (INR) within expanded...
AbstractBackground:Dalteparin sodium, a low-molecular-weight heparin, is indicated for prevention of clotting in the extracorporeal circuit during hemodialysis (HD). Product labeling recommends fixed single-bolus dose 5000 international units (IU) HD sessions lasting up to 4 hours, but adjustable dosing may be beneficial clinical practice.Objective:The aim PARROT study was investigate safety and efficacy an dalteparin patients with end-stage renal disease requiring 3 per week.Design:A...
Study Objectives. To determine patient factors associated with coagulopathy, to assess variables affecting response vitamin K 1 , describe ‐associated adverse reactions, and survey Canadian tertiary care hospitals about practice patterns in their intensive units (ICUs). Design. Retrospective chart audit prospective survey. Setting. Medical‐surgical ICU a 23‐bed complement care, university‐affiliated hospital, 47 hospitals. Patients. Forty‐eight critically ill patients nonconsumptive...