A5025362921- Natural Language Processing Techniques
- Topic Modeling
- Semantic Web and Ontologies
- Music History and Culture
- Biomedical Text Mining and Ontologies
- Advanced Text Analysis Techniques
- Protein Structure and Dynamics
- Cardiac, Anesthesia and Surgical Outcomes
- Text and Document Classification Technologies
- Information Retrieval and Search Behavior
- Spectroscopy and Quantum Chemical Studies
- Theater, Performance, and Music History
- Algorithms and Data Compression
- Race, History, and American Society
- Speech and dialogue systems
- Web Data Mining and Analysis
- Ferroelectric and Piezoelectric Materials
- Advanced Chemical Physics Studies
- Molecular Junctions and Nanostructures
- Data Management and Algorithms
- American Sports and Literature
- Multi-Agent Systems and Negotiation
- Health Policy Implementation Science
- Military History and Strategy
- Community Health and Development
Google (United Kingdom)
2024
DeepMind (United Kingdom)
2024
Simon Fraser University
2022-2023
Macquarie University
2022
Queensland Theological College
2022
East Lancashire Hospitals NHS Trust
2016-2021
Kalamazoo College
1976-2017
Purdue University West Lafayette
2016
University of Bristol
2015
Griffith University
2012-2014
Abstract The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure proteins and their interactions, enabling huge range applications protein design 2–6 . Here we describe our 3 model with substantially updated diffusion-based architecture that is capable predicting joint complexes including proteins, nucleic acids, small molecules, ions modified residues. new demonstrates improved accuracy over many previous specialized tools: far greater for protein–ligand...
Silicon micromachining and thin-film technology were used to fabricate iridium stimulating arrays which can be excite discrete volumes of the central nervous system. multichannel probes with thicknesses ranging from 1 40 mu m arbitrary two-dimensional shape fabricated using a high-yield, circuit-compatible process. Iridium sites are shown have similar characteristics wire electrodes. Accelerated pulse testing over eight million 100 A biphasic current pulses on 8000 m/sup 2/ demonstrated...
Demonstrating nonclassical effects over longer and distances is essential for both quantum technology fundamental science. The main challenge loss of photons during propagation, because considering only those cases where are detected opens a "detection loophole" in security whenever parties or devices untrusted. Einstein-Podolsky-Rosen (EPR) steering equivalent to an entanglement-verification task which one party (device) We derive arbitrarily loss-tolerant tests, enabling us perform...
The Canon Group is an informal organization of medical informatics researchers who are working on the problem developing a "deeper" representation formalism for use in exchanging data and applications. Individuals group represent experts such areas as knowledge computational linguistics, well variety subdisciplines. All share view that current mechanisms characterization phenomena either inadequate (limited or rigid) idiosyncratic (useful specific application but incapable being generalized...
Summary Pacific leatherback turtle Dermochelys coriacea populations have been declining precipitously. It has suggested that fishery‐associated mortality is the leading factor causing decline; however, sensitivity of leatherbacks to climate variability relative their population ecology unknown. We investigated effects interannual variability, as governed by El Niño Southern Oscillation (ENSO), on nesting ecology. used equatorial sea surface temperature (SST) anomaly data over various time...
A parallel searching algorithm based on eigenvector-following is used to generate databases of minima and transition states for an all-atom model the peptide Ac(ala)3NHMe a simplified bead protein. We analyze energy landscapes both systems using disconnectivity graphs upon potential free energy. This approach highlights role vibrational entropy in determining relative local minima. Thermodynamic properties calculated superposition are reasonable agreement with parallel-tempering Monte Carlo...
Information retrieval is an important application area of natural-language processing where one encounters the genuine challenge large quantities unrestricted text. This paper reports on a few simple, yet robust and efficient noun-phrase analysis techniques to create better indexing phrases for information retrieval. In particular, we describe hybrid approach extraction meaningful (continuous or discontinuous) subcompounds from complex noun using both corpus statistics linguistic heuristics....
The discrete path sampling technique is used to calculate folding pathways of the 16-amino acid beta hairpin-forming sequence from residues 41-56 B1 domain protein G. time obtained using master equation dynamics and kinetic Monte Carlo simulations, evolution different order parameters occupation probabilities groups minima are calculated characterize intermediates on pathway.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical studies of the oxy anionic substituent effectMichael L. Steigerwald, William A. Goddard III, and David EvansCite this: J. Am. Chem. Soc. 1979, 101, 8, 1994–1997Publication Date (Print):April 1, 1979Publication History Published online1 May 2002Published inissue 1 April 1979https://pubs.acs.org/doi/10.1021/ja00502a011https://doi.org/10.1021/ja00502a011research-articleACS PublicationsRequest reuse permissionsArticle...
A combination of methods, including laser-induced fluorescence excitation, fluorescence-dip infrared (FDIR) spectroscopy, and UV-UV hole-burning have been used to study the ultraviolet spectra single conformations two methyl-capped dipeptides: N-acetyl tryptophan amide (NATA) methyl (NATMA). Density functional theory calculations predict that all low-energy conformers NATA NATMA belong one conformational families: C5, with its extended dipeptide backbone, or C7eq, in which backbone forms a...
Information retrieval is an important application area of natural-language processing where one encounters the genuine challenge large quantities unrestricted text. This paper reports on a few simple, yet robust and efficient noun-phrase analysis techniques to create better indexing phrases for information retrieval. In particular, we describe hybrid approach extraction meaningful (continuous or discontinuous) subcompounds from complex noun using both corpus statistics linguistic heuristics....
From the Publisher: Biomedicine has become one of best-modeled domains from several perspectives - artificial intelligence, psychology, and social sciences; yet few studies have combined these points view. In this book, interdisciplinary strengths cognitive science offer fresh insights into biomedical problem solving. Cognitive Science in Medicine presents current research that focuses on issues results applying techniques to problems biomedicine. It includes material by researchers who...
In this paper, planning models developed in artificial intelligence are applied to the kind of that must be carried out by participants a conversation. A mechanism is defined, and short fragment free‐flowing videotaped conversation described. The bulk paper then devoted an attempt understand terms mechanism. This microanalysis suggests ways which augmented, reveals several important conversational phenomena deserve further investigation.
Since its inception in the late 1950s, field of Information Retrieval (IR) has developed tools that help people find, organize, and analyze information. The key early influences on are well-known. Among them H. P. Luhn's pioneering work, development vector space retrieval model by Salton his students, Cleverdon's Cranfield experimental methodology, Spärck Jones' idf , a series probabilistic models Robertson Croft. Until WorldWideWeb (Web), IR was greatest interest to professional information...
Abstract The analysis of individuals with ciliary chondrodysplasias can shed light on sensitive mechanisms controlling ciliogenesis and cell signalling that are essential to embryonic development survival. Here we identify TCTEX1D2 mutations causing Jeune asphyxiating thoracic dystrophy partially penetrant inheritance. Loss impairs retrograde intraflagellar transport (IFT) in humans the protist Chlamydomonas , accompanied by destabilization IFT dynein motor. We thus define as an integral...
A parallel searching algorithm based on eigenvector-following is used to generate databases of minima and transition states for all-atom models Ac(ala)12NHMe Ac(ala)16NHMe. The AMBER95 force field Cornell et al. [J. Am. Chem. Soc. 117, 5179 (1995)] employed both with without a simple implicit solvent. We use master equation approach analyze the dynamics systems, relate results potential energy landscapes using disconnectivity graphs. low-lying regions are compared found be remarkably...
For the small peptide met-enkephalin in implicit aqueous solvent a connected database of potential energy minima and transition states is constructed refined based on kinetic criteria, using discrete path sampling method. A comparison this technique with parallel tempering Monte Carlo simulations shows that it produces satisfactory configuration space occupied at 298 K. The predicted to show folding transition, time scales for are obtained, along description significant intermediates.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSamarium(III)-catalyzed hydroboration of olefins with catecholborane. A general approach to the synthesis boronate estersDavid A. Evans, Alexander R. Muci, and Rainer StuermerCite this: J. Org. Chem. 1993, 58, 20, 5307–5309Publication Date (Print):September 1, 1993Publication History Published online1 May 2002Published inissue 1 September 1993https://pubs.acs.org/doi/10.1021/jo00072a007https://doi.org/10.1021/jo00072a007research-articleACS...