A5065339333- Physical Education and Pedagogy
- Blood Pressure and Hypertension Studies
- Children's Physical and Motor Development
- Education Systems and Policy
- Hormonal Regulation and Hypertension
- Inclusion and Disability in Education and Sport
- Renin-Angiotensin System Studies
- European Political History Analysis
- Historical Studies and Socio-cultural Analysis
- Palliative Care and End-of-Life Issues
- Indigenous and Place-Based Education
- Diverse Educational Innovations Studies
- Jewish and Middle Eastern Studies
- Cancer Genomics and Diagnostics
- Physical Activity and Health
- Youth Development and Social Support
- Chronic Kidney Disease and Diabetes
- Early Childhood Education and Development
- Family and Disability Support Research
- Psychoanalysis and Psychopathology Research
- Nerve injury and regeneration
- Heart Failure Treatment and Management
- Obesity, Physical Activity, Diet
- American Constitutional Law and Politics
- Patient-Provider Communication in Healthcare
Emory University
1998-2024
University of New England
2014-2023
Center for Autism and Related Disorders
2022
University of Alabama at Birmingham
2022
Children's Hospital of Philadelphia
2022
Society of Critical Care Medicine
2021-2022
Royal University of Bhutan
2021
Education and Early Childhood Development
2021
Queensland University of Technology
2021
Sinai Health System
2018
Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates the mitogen new member of epidermal (EGF) family. This EGF-like (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma far more potent than EGF. HB-EGF also expressed in cultured human macrophages may be involved macrophage-mediated...
The hyper-IgE syndrome with recurrent infections is a rare immunodeficiency characterized by skin and pulmonary abscesses extremely elevated levels of IgE in serum. Associated facial skeletal features have been recognized, but their frequency unknown, the genetic basis poorly understood.
Here we describe the cloning of a human 4.5-kilobase gene and 800-base pair cDNA encoding form representing major peak activity protein mass (peak A).The clones encode mature peptide 124 amino acids, which follows prepeptide 20 residues.The deduced acid sequence constitutes an enzyme "Type 11" class PLA2s, resembles PLAzs from other mammalian sources.This represents first report full length non-pancreatic PLAz sequence.Active transcription this was detected in two different inflammatory cell...
The major class of atrial natriuretic peptide (ANP) receptors was isolated from cultured vascular smooth muscle cells, and a partial amino acid sequence obtained. This allowed the isolation cDNA clones which entire established. cell ANP receptor appears to be synthesized as 537-amino precursor with an N-terminal membrane translocation signal. mature form consists 496 acids single potential transmembrane domain predicting 37-amino cytoplasmic large, acidic, extracellular low in cysteine...
Molecular screening for BRCA1 and BRCA2 mutations is now an established component of risk evaluation management familial breast cancer. Features hereditary cancer include early age-of-onset over-representation the 'triple-negative' phenotype (negative estrogen-receptor, progesterone-receptor HER2). The decision to offer genetic testing a patient usually based on her family history, but in absence history cancer, some women may qualify and/or pathologic features cancer.We studied 54 who were...
Objective To examine the clinical utility of Clock Test for identifying dementia. Design Group comparisons. Setting A hospital‐based out‐patient diagnostic clinic. Patients Volunteer sample elderly individuals (normal elderly, NE, n = 62) and a referred probable Alzheimer Disease (AD, 58) patients meeting NINCDS‐ADRDA criteria. Main Outcome Measure The is composed three components: Drawing, Setting, Reading. detailed scoring system qualitative as well quantitative evaluation Drawing errors...
The alpha-thalassemia-2 (alpha-thal-2) genotype or mild alpha-thalassemia gene consists of a single structural alpha-globin on the chromosome that normally bears two genes. We used blot hybridization to investigate variation in molecular organization this and determine distributions these variations world population. Two different patterns responsible for alpha-thal-2 were found: first was result 4.2-kilobase pair deletion involving normal 5' (leftward genotype), second probably crossover...
Focal and segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases to terminate in ESRD. A complete remission (CR) confers an excellent long-term prognosis, but quantitative benefits partial remissions (PR) have not been defined. This study evaluated rate renal function decline (slope creatinine clearance) survival nephrotic FSGS patients with CR, PR, or no remission. It also examined relapse from its impact on outcome. Multivariate analysis included clinical...
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, supports survival developing basal forebrain cholinergic neurons in vitro and is retrogradely transported by medial septum diagonal band following intrahippocampal injections vivo. To substantiate potential role for BDNF maintenance adult brain, we assessed ability to sustain phenotype septal unilateral transection fimbria. BDNF, NGF, or vehicle solutions were infused continuously female rats either into lateral...
We studied 47 patients with sickle-cell anemia to determine the effect of alpha-thalassemia on severity their hemolytic anemia. diagnosed objectively by using alpha-globin-gene mapping detect deletions, studying 25 subjects normal four alpha-globin-genes, 18 three, and two. The mean hemoglobin, hematocrit, absolute reticulocyte levels (+/- S.D.) were 7.9 +/- 0.9 g per deciliter (4.9 0.6 mmol liter), 22.9 2.9 cent, 501,000 126,000 cubic millimeter, respectively, in non-thalassemic group; 9.8...
Cardiovascular disease remains the primary cause of mortality in patients who are maintained on hemodialysis. Arterial stiffness and insulin resistance independent risk factors for cardiovascular this population. In healthy individuals, higher physical conditioning is associated with reduced arterial stiffness. Exercise reduces glucose intolerance sedentary, overweight individuals diabetic patients. The purpose study was to determine impact an exercise program a group effect training 11 were...
The classic that revolutionized the way Americans see marriage. Sold more than 35 million copies and translated into 14 languages.
Patient self-management has been shown to improve health outcomes. We developed a smartphone-based system boost self-care by patients with CKD and integrated its use into usual care. determined acceptability examined changes in several clinical parameters.We recruited stage 4 or 5 attending outpatient renal clinics who responded general information newsletter about this 6-month proof-of-principle study. The smartphone application targeted four behavioral elements: monitoring BP, medication...
BackgroundMetastatic triple-negative breast cancer (mTNBC) has a poor prognosis and aggressive clinical course. tnAcity evaluated the efficacy safety of first-line nab-paclitaxel plus carboplatin (nab-P/C), gemcitabine (nab-P/G), (G/C) in patients with mTNBC.Patients methodsPatients pathologically confirmed mTNBC no prior chemotherapy for metastatic BC received (1 : 1 1) nab-P 125 mg/m2 C AUC 2, G 1000 mg/m2, or all on days 1, 8 q3w. Phase II primary end point: investigator-assessed...
Long-term nocturnal hemodialysis, which uses longer and more frequent sessions than conventional lowers clinic blood pressure left ventricular mass. We tested the hypotheses that short-term hemodialysis would (1) reduce ambulatory pressure; (2) cause peripheral vasodilation; (3) lower plasma norepinephrine concentration; (4) improve arterial response to reactive hyperemia (a marker of endothelium-dependent vasodilation). studied 18 consecutive patients (age, 41+/-2; [mean+/-SEM]) before 1 2...
Abstract. It has been demonstrated previously that moderate hyperglycemia without glucosuria can increase plasma renin activity and mean arterial pressure in young healthy males with early uncomplicated type 1 diabetes mellitus. This study was conducted to extend these observations by testing the hypothesis mild affect renal function increasing angiotensin system (RAS) diabetic humans. The included 10 men women early, (duration <5 yr), all ingesting a controlled sodium protein diet. They...
ABSTRACT. It has been demonstrated elsewhere that circulating renin angiotensin system (RAS) components peak when plasma estrogen levels are highest, during the luteal phase of normal menstrual cycle. This phenomenon attributed to "activation" RAS. The end-organ vasoconstrictive response this not well established. In two related experiments, RAS was studied in healthy, premenopausal women predefined phases first experiment, and systemic hemodynamic incremental lower body negative pressure...
Evidence suggests that gender differences exist in renin-angiotensin system (RAS) function. It was hypothesized women may differ also their response to RAS blockade. The renal and peripheral hemodynamic responses incremental dosages of an angiotensin receptor blocker the degree II (AngII) insensitivity achieved during 8 wk were examined men women. Participants 30 young healthy (n = 15; mean age 27 +/- 2) 28 who on a controlled sodium protein diet for 1 before each study. humoral, renal,...
Recent studies showed that brain-derived neurotrophic factor (BDNF) prevents developing motoneurons from naturally occurring and axotomy-induced cell death. Here we examined whether adult retain responsiveness to BDNF. Consistent with previous studies, found spinal brainstem expressed the mRNA of BDNF receptor, trkB. In addition, trkB immunoreactivities were readily detected in motoneurons. We then demonstrated axotomized responded exogenous administered locally markedly attenuated...