A5002244032- Blood Pressure and Hypertension Studies
- Obstructive Sleep Apnea Research
- Sodium Intake and Health
- Pregnancy and preeclampsia studies
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Liver Disease and Transplantation
- Mobile Health and mHealth Applications
- Heart Failure Treatment and Management
- Sleep and related disorders
- Maternal and fetal healthcare
- Renal function and acid-base balance
- Hormonal Regulation and Hypertension
- Dialysis and Renal Disease Management
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Renal Transplantation Outcomes and Treatments
- Kidney Stones and Urolithiasis Treatments
- Cardiovascular Health and Disease Prevention
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Chronic Disease Management Strategies
Lunenfeld-Tanenbaum Research Institute
2012-2024
University Health Network
2014-2024
Sinai Health System
2018-2024
University of Toronto
2014-2023
Mount Sinai Hospital
2013-2023
Toronto General Hospital
1980-2023
Sinai Hospital
2022
Public Health Ontario
2021
Hospital for Sick Children
1979-2016
SickKids Foundation
1979-2016
The Canadian Continuous Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure trial tested the hypothesis that continuous positive airway pressure (CPAP) would improve survival rate without heart transplantation of patients who have central sleep apnea failure.
Objectives To determine the prevalence of obstructive sleep apnoea (OSA) in adult patients with drug-resistant hypertension, a common problem tertiary care facility. Design Cross-sectional study. Setting University hypertension clinic. Patients and methods Adults defined as clinic blood pressure ≥ 140/90 mmHg, while taking sensible combination three or more antihypertensive drugs, titrated to maximally recommended doses. Each 41 participants completed an overnight polysomnographic study all...
In the main analysis of Canadian Continuous Positive Airway Pressure (CPAP) for Patients with Central Sleep Apnea (CSA) and Heart Failure Trial (CANPAP), CPAP had no effect on heart transplant-free survival; however, only reduced mean apnea-hypopnea index to 19 events per hour sleep, which remained above trial inclusion threshold 15. This stratified CANPAP tested hypothesis that suppression CSA below this by would improve left ventricular ejection fraction survival.Of 258 failure patients in...
Background —Continuous positive airway pressure (CPAP) improves cardiac function in patients with congestive heart failure (CHF) who also have Cheyne-Stokes respiration and central sleep apnea (CSR-CSA). However, the effects of CPAP CHF without CSR-CSA not been tested, long-term this treatment on clinical cardiovascular outcomes are unknown. Methods Results —We conducted a randomized, controlled trial which 66 (29 37 CSR-CSA) were randomized to either group that received nightly or control...
The effects of less-tight versus tight control hypertension on pregnancy complications are unclear.
During the COVID-19 pandemic, telemedicine has emerged worldwide as an indispensable resource to improve surveillance of patients, curb spread disease, facilitate timely identification and management ill people, but, most importantly, guarantee continuity care frail patients with multiple chronic diseases. Although during thrived, its adoption moved forward in many countries, important gaps still remain. Major issues be addressed enable large scale implementation include: (1) establishing...
To determine whether clinical outcomes differed by occurrence of severe hypertension in the international CHIPS trial (Control Hypertension Pregnancy Study), adjusting for interventions "less tight" (target diastolic blood pressure [dBP] 100 mm Hg) versus "tight" control dBP 85 Hg). In this post-hoc analysis data from 987 women with nonsevere nonproteinuric preexisting or gestational hypertension, mixed effects logistic regression was used to compare following according allocated group and...
Restenosis is a major limitation of coronary angioplasty. Directional atherectomy was developed with the expectation that it would provide better results than angioplasty, including lower rate restenosis. We undertook randomized, multicenter trial to compare rates restenosis for and angioplasty when used treat lesions proximal left anterior descending artery.
This study was undertaken to determine whether abolition of obstructive sleep apnoea (OSA) by continuous positive airway pressure (CPAP) could reduce blood (BP) in patients with refractory hypertension. In 11 hypertensive OSA, the acute effects CPAP on nocturnal BP were studied during and its longer term 24-h ambulatory after 2 months. During a single night9s application, abolished OSA reduced systolic stage from 138.3±6.8 126.0±6.3 mmHg. There also trend towards reduction average diastolic...
To determine the true prevalence of impaired glucose tolerance (IGT), NIDDM, and associated risk factors by age sex in an isolated native community.A community-wide survey using a 75-g oral test (OGTT) was undertaken remote reserve Sandy Lake, Ontario, Canada. Measurements for obesity included waist-to-hip circumference, BMI, percentage body fat.A total 728 individuals were enrolled, representing community participation rate 72%. The overall crude NIDDM 17.2% (18.1% females 16.0% males)...
Lowering blood pressure reduces cardiovascular risk, yet hypertension is poorly controlled in diabetic patients. In a pilot study we demonstrated that home telemonitoring system, which provided self-care messages on the smartphone of hypertensive patients immediately after each reading, improved control. Messages were based care paths defined by running averages transmitted readings. The present tests system's effectiveness randomized, trial with uncontrolled systolic hypertension. Of 244...
Obstructive sleep apnea occurs frequently in patients with drug-resistant hypertension. The factors accounting for this observation, however, are unclear. Both conditions demonstrate clinical features suggestive of extracellular fluid volume overload. aims study were to examine whether the spontaneous overnight shift from legs upper body is associated obstructive hypertensive subjects and its magnitude greater Leg circumference calf neck measured before after (n = 25) controlled (n=15)...
BACKGROUND: Allogeneic blood transfusion is associated with reactions, infection transmission, and postoperative morbidity mortality. The objective of this study was to develop validate an accurate simple clinical index stratify cardiac surgery patients according their needs. METHODS AND RESULTS: Data on consecutive adult who underwent at Toronto General Hospital (n = 11,113) Sunnybrook Women’s College Health Sciences Center 5316) between May 1999 June 2004 were collected for the...
GLP-1 receptor (GLP-1R) agonists induce natriuresis and reduce blood pressure (BP) through incompletely understood mechanisms. We examined the effects of acute 21-day administration liraglutide on plasma atrial natriuretic peptide (ANP), urinary sodium excretion, office 24-h BP, heart rate (HR).Liraglutide or placebo was administered for 3 weeks to hypertensive subjects with type 2 diabetes in a double-blinded, randomized, placebo-controlled crossover clinical trial ambulatory setting. End...