A5057135061- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Connexins and lens biology
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Acute Ischemic Stroke Management
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Nicotinic Acetylcholine Receptors Study
- Electrolyte and hormonal disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Syncope and Autonomic Disorders
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Heart Rate Variability and Autonomic Control
- Neuroscience and Neuropharmacology Research
- Advanced MRI Techniques and Applications
- Healthcare Technology and Patient Monitoring
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Blood Pressure and Hypertension Studies
Zealand University Hospital
2016-2025
Roskilde Sygehus
2016-2025
Roskilde University
2012-2023
University of Copenhagen
1996-2022
Copenhagen University Hospital
2013-2021
Rigshospitalet
2016-2017
Zealand Pharma (Denmark)
2004-2007
Montreal Heart Institute
2006-2007
Université de Montréal
2007
Women's Health Research Institute
2007
Background: Stroke is an increasing health problem worldwide. Atrial fibrillation (AF) a major risk factor for stroke, and the attention given to AF screening rising, as new monitoring technologies emerge. We aimed evaluate performance of large panel strategies assess population characteristics associated with diagnostic yield. Methods: Individuals stroke factors but without were recruited from general undergo implantable loop recorder. New-onset lasting ≥6 minutes was adjudicated by senior...
Research suggests NT-proBNP (N-terminal pro-B-type natriuretic peptide) to be a strong predictor of incident atrial fibrillation (AF) and stroke. However, its utility in AF screening remains unknown. The aim this study was investigate as potential marker for efficacy with respect yield stroke prevention.
BACKGROUND: Left atrial (LA) speckle tracking provides detailed information on function. Its utility for predicting subclinical fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring. METHODS: This was an echocardiographic substudy of the LOOP study, where elderly at risk stroke were randomized receive a loop recorder (Reveal LINQ) or control. Participants who received included in...
Abnormal intercellular communication caused by connexin dysfunction may be involved in atrial fibrillation (AF). The present study assessed the effect of gap junctional conduction-enhancing peptide rotigaptide on AF maintenance substrates that result from congestive heart failure induced 2-week ventricular tachypacing (240 bpm), (ATP; 400 bpm for 3 to 6 weeks), and isolated myocardial ischemia.Electrophysiological epicardial mapping were performed before after administration dogs with ATP...
There is increasing interest in heart rhythm monitoring and technologies to detect subclinical atrial fibrillation (AF), which may lead incidental diagnosis of bradyarrhythmias.To assess bradyarrhythmia prevalence prognostic significance persons screened for AF using implantable loop recorder (ILR) compared with unscreened persons.This was a post hoc analysis the Implantable Loop Recorder Detection Atrial Fibrillation Prevent Stroke (LOOP) randomized clinical trial, took place 4 sites...
Abstract Aims We aimed to investigate whether left atrial (LA) markers from cardiovascular magnetic resonance (CMR) were able predict fibrillation (AF) in elderly patients with risk factors for stroke. Methods and results At baseline, 203 participants stroke but without history of AF underwent advanced CMR received an implantable loop recorder. During a median 40 (37–42) months continuous monitoring, incident was detected 79 (39%). With regards markers, steep increase incidence rate seen LA...
Abstract Background Derangement of plasma potassium (p-K) is associated with an increased risk developing cardiac arrhythmias. Small studies indicate that variations in p-K levels may also affect the mechanical function cardiomyocytes. A recent clinical study demonstrated improvements myocardial by echocardiography after a short follow-up patients randomized to increasing treatment. However, long-term effect on unknown. Purpose To investigate if treatment improves diastolic and systolic...
The antiarrhythmic and cardioprotective effect of increasing gap junction intercellular communication during ischemia/reperfusion injury has not been studied. peptide rotigaptide (previously ZP123), which maintains communication, was tested in dogs subjected to a 60-min coronary artery occlusion 4 h reperfusion. Rotigaptide administered i.v. 10 min before reperfusion as bolus + infusion at doses 1 ng/kg ng/kg/h (<i>n</i> = 6), 100 5), 1000 8), μg/kg/h vehicle control 5). Premature...
Atrial fibrillation (AF) screening trials have failed to demonstrate a significant reduction in stroke risk. The impact on severity and the importance of prior strokes are unknown.To assess characteristics patients undergoing implantable loop recorder (ILR) for AF vs usual care stroke.This was post hoc analysis Fibrillation Detected by Continuous Electrocardiogram Monitoring Using Implantable Loop Recorder Prevent Stroke High-Risk Individuals (LOOP) randomized clinical trial. Persons 70...
Objective: As atrial conduction slowing is important in the pathogenesis of reentry arrhythmias, a drug that increases or prevents could serve to prevent arrhythmias. In this study, we investigated whether novel stable antiarrhythmic peptide analog, ZP123, was able slowing. Methods: We examined effect ZP123 on metabolic stress‐induced changes velocity (CV) and dynamic CV restitution isolated left atria from male Sprague‐Dawley rats. performed binding broad panel 80 different cardiac...
Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) flutter (AFL). Our objective was to determine whether GAP-134 [(2<i>S</i>,4<i>R</i>)-1-(2-aminoacetyl)-4-benzamido-pyrrolidine-2-carboxylic acid], a small dipeptide gap modifier, improve ultimately prevent AF/AFL. In rat strips subjected metabolic stress, prevented significantly velocity slowing at 10 nM compared...
Insights into subclinical atrial fibrillation (AF) development are warranted to inform the strategies of screening and subsequent clinical management upon AF detection. Hence, this study sought characterize onset progression with respect 12-lead electrocardiogram (ECG) parameters.We included AF-naïve individuals aged 70-90 years additional stroke risk factors who underwent implantable loop recorder (ILR) monitoring in LOOP Study. Using data from daily ILR recordings computerized analysis...
Morphology-voltage-P-wave-duration (MVP) score combining P-wave duration (PWD), voltage in lead I (PWVI), and interatrial block (IAB) has been demonstrated to predict atrial fibrillation (AF). Therefore, this study aimed examine MVP its components as potential predictors of AF screening effects on stroke prevention. This was a secondary analysis the LOOP Study (Atrial Fibrillation detected by Continuous ECG Monitoring using Implantable Loop Recorder prevent Stroke High-risk Individuals)...
Background The ABC‐stroke score is a risk scheme for prediction of stroke or systemic embolism (SE) in atrial fibrillation (AF). This study sought to examine whether the could be useful predicting AF‐naïve individuals and stratifying AF screening. Methods Results LOOP (Atrial Fibrillation Detected by Continuous ECG Monitoring Using Implantable Loop Recorder Prevent Stroke High‐Risk Individuals) randomized 6004 aged 70 90 years with factors either screening an implantable loop recorder...