A5101940836- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Ion channel regulation and function
- Diabetes Treatment and Management
- Nonlinear Dynamics and Pattern Formation
- Acute Ischemic Stroke Management
- Cardiovascular Effects of Exercise
- Intracerebral and Subarachnoid Hemorrhage Research
- Diabetes Management and Research
- Cardiac Arrest and Resuscitation
- Advanced Mathematical Modeling in Engineering
- Quantum chaos and dynamical systems
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- stochastic dynamics and bifurcation
- Omental and Epiploic Conditions
- Traumatic Brain Injury and Neurovascular Disturbances
- Zebrafish Biomedical Research Applications
- Neurological disorders and treatments
- Heme Oxygenase-1 and Carbon Monoxide
- Soft tissue tumor case studies
- Surgical Sutures and Adhesives
- Advanced Neuroimaging Techniques and Applications
- Case Reports on Hematomas
- Takotsubo Cardiomyopathy and Associated Phenomena
Providence University
2004-2022
Buddhist Tzu Chi General Hospital
2017
GTx (United States)
2009
Kaohsiung Medical University Chung-Ho Memorial Hospital
2009
Providence College
2009
National Defense Medical Center
2003-2008
Tri-Service General Hospital
2003-2008
Taipei Hospital
2006-2007
Activating transcription factor 4 (ATF4) is constitutively expressed in a variety of tissues, and regulates several pathological features associated with metabolic diseases such as non-alcoholic fatty liver (NAFLD) obesity. However, the role ATF4 animal model systems poorly understood. To investigate functions zebrafish, we conditionally proteins, using Tet-off transgenic system. We observed early-onset hyperlipidaemia steatosis zebrafish (ATs) without doxycycline treatment (ATs - Dox). Oil...
Abstract Objective Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM from a nationwide cohort. Methods using different after an initial therapy > 90 days were identified Taiwan National Health Insurance Database. Five classes ADAs, including sulphonylureas (SU), glinides,...
Background: Although the ABC/2 formula has been widely used to estimate volume of intracerebral hematoma (ICH), tends overestimate volume. The volume-related imprecision not documented quantitatively. Purpose: To investigate volume-dependent overestimation by comparing it with computer-assisted volumetric analysis (CAVA). Material and Methods: Forty patients who had suffered spontaneous ICH undergone non-enhanced brain computed tomography scans were enrolled in this study. was estimated...
We report a 22-year-old man with solid mass in the right proximal leg, which was furned out to be gossypiboma.MR imaging revealed well-defined lesion that showed intermediate signal intensity at T1-weighted (T1WI) and slightly high T2-weighted (T2WI).Wavy, low-signal-intensity stripes were visible within fluid-filled central cavity.At surgical exploration, sponge, retained after previous knee surgery, discovered, it found granuloma had developed.Pathologic examination granulomatous...
Background: Atrial fibrillation (AF) increases the risk of dementia. Whether pharmacological rhythm control AF can reduce dementia compared to rate strategy remains unclear. We hypothesize that is better than in preventing Methods: patients aged ≥65 years were identified from Taiwan National Health Insurance Database. Patients receiving anti-arrhythmic drugs at a cumulative defined daily dose (cDDD) >30 within first year enrollment constituted group. who used medications for cDDD A...
Timothy syndrome (TS) is a malignant form of congenital long QT with mode arrhythmia onset often triggered by enhanced sympathetic tone. We sought to explore mechanisms which β-adrenergic stimulation (BAS) modulates arrhythmogenesis and identify potential targeted sites antiarrhythmic therapy in TS. Using dynamic Luo-Rudy ventricular myocyte model incorporated detailed intracellular Ca 2+ cycling, along its one-dimensional multicellular strand, we simulated various clinical scenarios TS,...
The authors studied seven patients with mitochondrial DNA (mtDNA) myopathy.Over time, there was a progressive depletion of mtDNA, which preferentially affected wild-type genomes.This suggests that loss mtDNA is major feature myopathy, and preventing has treatment implications.
Abstract Background The impact of hypoglycaemic episode (HE) on the risk ventricular arrhythmia (VA) and sudden cardiac arrest (SCA) remains unclear. We hypothesized that HE increases both VA SCA glucose‐lowering agents causing also increase VA/SCA in patients with type 2 diabetes (T2D). Methods Patients aged 20 years or older newly diagnosed T2D were identified using Taiwan National Health Insurance Database. was defined as presentation coma specified/unspecified hypoglycaemia. control...
Solitary fibrous tumor (SFT) is a benign mensenchymal neoplasm of spindle-cell origin. The authors report the case 50-year-old man with SFT arising from meninges left parasellar region cavernous sinus involvement. was demonstrated isointense on T1-weighted and heterogeneously hypointense T2-weighted magnetic resonance imaging (MRI) strong contrast enhancement. preoperative MRI diagnosis meningioma or hemangiopericytoma. Pathological study revealed an that stained positive...
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a malignant arrhythmogenic disorder linked to mutations in the cardiac ryanodine receptor (RyR2) and calsequestrin, predisposing young syncope arrest. To define role of β-adrenergic stimulation (BAS) identify potential therapeutic targeted sites relating intracellular calcium cycling, we used Luo-Rudy dynamic myocyte model incorporated with interacting Markov models L-type Ca(2+) channel (I(Ca,L)) RyR2 simulate heterozygous...
We study a two-point free boundary problem for the curvature flow equation. By studying corresponding nonlinear initial value problem, we obtain existence and uniqueness of forward self-similar solution this problem. The curve is called expanding curve. also derive asymptotic stability
The data relates to the cohort of patients with atrial fibrillation (AF) from National Health Insurance Research Database Taiwan, "Rhythm Control Better Prevents Stroke and Mortality than Rate Strategies in Patients Atrial Fibrillation - A Nationwide Cohort Study" (Weng et al., press). AF might receive either rate or rhythm control strategy according medication used. baseline groups was included this dataset. Multivariate Cox hazards regression model used evaluate hazard ratio (HR) for major...
Dural arteriovenous fistula (DAVF) is an abnormal shunt that occurs in the dura matter within or near a dural sinus. The clinical manifestations vary. authors report herein rare case of type III DAVF presenting with coexisting intracranial hemorrhage (ICH) and venous infarction evidenced by computed tomography (CT) diffusion-weighted magnetic resonance imaging. Conventional angiography proved right middle meningeal artery occipital supplied DAVF, direct drainage into cortical veins superior sagittal
Abstract We study the structure of solutions an initial value problem arising in steadily rotating spiral waves kinematic theory excitable media. In particular, we prove that under certain conditions there is a unique global positive monotone increasing solution.