A5002356179- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Healthcare Policy and Management
- Medication Adherence and Compliance
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Screening and Detection
- Global Cancer Incidence and Screening
- Electronic Health Records Systems
- Global Health Care Issues
- COVID-19 epidemiological studies
- Diabetes Management and Research
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Nursing Diagnosis and Documentation
- Ethics in Clinical Research
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes Treatment and Management
- Pharmaceutical Economics and Policy
- Gastrointestinal motility and disorders
- Genomics and Rare Diseases
- Central Venous Catheters and Hemodialysis
- Esophageal Cancer Research and Treatment
- Multiple and Secondary Primary Cancers
University of Toronto
2020-2022
Canadian Partnership Against Cancer
2020-2021
University of Calgary
2018-2020
University Health Network
2020
Pontificia Universidad Javeriana
2015-2019
Alberta Bone and Joint Health Institute
2018
O'Brien Institute
2018
Background Population-based cancer screening can reduce burden but was interrupted temporarily due to the COVID-19 pandemic. We estimated long-term clinical impact of breast and colorectal interruptions in Canada using a validated mathematical model. Methods used OncoSim cancers microsimulation models explore scenarios primary stops for 3, 6, 12 months followed by 6–24-month transition periods reduced volumes. For cancer, we changes incidence over time, additional advanced-stage cases...
Colorectal cancer screening programmes worldwide have been disrupted during the COVID-19 pandemic. We aimed to estimate impact of hypothetical disruptions organised faecal immunochemical test-based colorectal on short-term and long-term incidence mortality in three countries using microsimulation modelling.In this modelling study, we used four country-specific models-Policy1-Bowel (Australia), OncoSim (Canada), ASCCA MISCAN-Colon (the Netherlands)-to potential COVID-19-related Australia,...
The effect of surface PEGylation on nanoparticle transport through an extracellular matrix (ECM) is important determinant for tumor targeting success. Fluorescent stealth liposomes (base lipid DOPC) were prepared incorporating different proportions PEG-grafted lipids (2.5, 5 and 10% the total content) a series PEG molecular weights (1000, 2000 5000 Da). ECM was modelled using collagen matrix. kinetics PEGylated liposome adhesion to in matrices tracked fluorescence correlation spectroscopy...
Cancer poses a substantial health and economic burden on patients caregivers in Canada. Previous reviews have estimated the indirect cost as work-related productivity losses associated with cancer. However, these estimates require updating complementing more comprehensive data that include relevant dimensions beyond labor market costs, such patient time, lost leisure time home losses. A systematic review of literature was conducted to identify studies published from 2006 2020 measured...
Background: Smoking by cancer patients and survivors causes adverse treatment outcomes, but little information is available about how smoking can affect costs. Methods: We developed a model to estimate attributable failure because of continued after diagnosis (AFs). Canadian health system data were used determine the additional cost for AFs most common cancers in Canada. Results: Of 206,000 diagnosed with annually, an estimated 4789 experienced afs. The annual incremental associated treating...
Screening psoriasis patients for psoriatic arthritis (PsA) is intended to identify at earlier stages of the disease. Early treatment expected slow disease progression and delay need biologic therapy. Our objective was determine cost-effectiveness screening PsA in with Canada.A Markov model built estimate costs quality-adjusted life years (QALYs) tools patients. The included Toronto Psoriatic Arthritis Screen, Psoriasis Epidemiology Tool, Evaluation, Questionnaire (EARP) questionnaires....
Background: Valle del Cauca is the region with fourth-highest number of COVID-19 cases in Colombia (>50,000 on September 7, 2020). Due to lack anti-COVID-19 therapies, decision-makers require timely and accurate data estimate incidence disease availability hospital resources contain pandemic.
 Methods: We adapted an existing model local context forecast resource use assuming different scenarios: (1) implementation quarantine from 1st October 15th (average daily growth rate 2%); (2-3)...
OBJECTIVES: To estimate the extent to which Canadians are averse health inequalities, a critical component for equity-informative economic evaluations but lacking in Canadian context. METHODS: We conducted three experiments among representative sample of adults living Canada elicit value judgements about reducing income-related inequality vs. improving population health. Each experiment compared two programs: (Experiment 1) universal and tailored vaccination; 2) non-specific prevention...
Object. Controversy exists regarding the best treatment option for unruptured anterior circulation aneurysms (UA); we performed a long-term cost-effectiveness analysis comparing different options from an economic standpoint.
 Methods. A decision-tree model was built based on hypothetical cohort of 1,000 patients undergoing UA. Health outcomes and cost were modeled over projected lifetime. All outcome probabilities likelihood ratios obtained natural history studies. Costs assessed...
Introduction: Screening for psoriatic arthritis (PsA) is expected to identify patients at earlier stages of the disease. Early treatment slow disease progression and delay need biologic therapy. This study estimated cost-effectiveness screening tools PsA in Canada. Methods: A Markov model was built estimate associated costs quality-adjusted life-years (QALYs) using topical psoriasis. The included: Toronto Psoriatic Arthritis (ToPAS) questionnaire; Psoriasis Epidemiology Tool (PEST);...