A5023502250- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Aortic Disease and Treatment Approaches
- Endoplasmic Reticulum Stress and Disease
- Fungal and yeast genetics research
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- Gastric Cancer Management and Outcomes
- Plant Molecular Biology Research
- Gene Regulatory Network Analysis
- Infectious Aortic and Vascular Conditions
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Aquaculture Nutrition and Growth
- EEG and Brain-Computer Interfaces
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer-related Molecular Pathways
Fudan University
2014-2025
Institute of Microelectronics
2025
State Key Laboratory of ASIC and System
2025
Minhang District Central Hospital
2021-2025
State Key Laboratory of Genetic Engineering
2002-2024
Blood Center of Zhejiang Province
2024
Zhejiang Cancer Hospital
2024
Zhejiang University
2024
Second Affiliated Hospital of Zhejiang University
2024
Guizhou Provincial People's Hospital
2021-2023
Abstract Background Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed death ligand 1 (PD-L1) promoted progression drug resistance, facilitated tumor immune evasion. However, the detailed molecular mechanisms are still largely unknown. In present study, we aimed to explore role of circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis in regulation NSCLC progression, resistance microenvironment. Methods Real-Time qPCR Western Blot analysis were conducted...
Retrograde type A aortic dissection has been deemed a rare complication after endovascular stent graft placement for B dissection. However, this life-threatening event appears to be underrecognized and is worth being investigated further.Eleven of 443 patients developed retrograde during or grafting from August 2000 June 2007. Of these 11 patients, 3 had Marfan syndrome. The Kaplan-Meier estimate the rate freedom at 36 months 97.4% (95% confidence interval, 0.95 0.99). new entry was located...
Resistin is a newly discovered adipocyte-derived cytokine that may play an important role in insulin resistance, diabetes, adipogenesis, inflammation, and cardiovascular disease. However, it largely unknown whether resistin impairs endothelial functions by affecting the nitric oxide synthase (eNOS) system. In this study, we determined effect of human recombinant protein on eNOS expression regulation coronary artery cells (HCAECs). When were treated with clinically relevant concentrations (40...
Digestion and detoxification are the two most important functions of liver, liver cells always keep a high metabolism level active vesicular traffic. The malfunction traffic system might be cause abnormal biological behavior cancerous cells. Ras superfamily is known to regulate various steps in eukaryotic It would significant determine change transport molecules such as members carcinogenesis In present study, we have cloned nine novel genes encoding human small GTPases: RAB1B, RAB4B, RAB10,...
Background Colorectal cancer (CRC) is the third most common in China, however, publicly available, descriptive information on clinical epidemiology of CRC limited. Methods Patients diagnosed with primary during 2005 through 2014 were sampled from 13 tertiary hospitals 9 provinces across China. Data related to sociodemographic characteristics, use diagnostic technology, treatment adoption, and expenditure extracted individual medical records. Results In full cohort 8465 patients, mean ± SD...
Proliferating cells need to evaluate the environment determine optimal timing for cell cycle entry. However, how this is achieved not well understood. Here, we show that, in budding yeast, G1 inhibitor Whi5 a key environmental indicator and plays crucial role coordinating growth division. We found under variety of nutrient stress conditions, amount proportional cell’s doubling time environment, which turn influences next In addition, coordination between division further fine-tuned by...
Background Circular RNAs (circRNAs) and their derived peptides represent largely unchartered areas in cellular biology, with many potential roles yet to be discovered. This study aimed elucidate the role molecular interactions of circSHPRH its peptide derivative SHPRH-146aa pathogenesis neuroblastoma (NB). Methods NB samples GSE102285 dataset were analyzed measure expression, followed by vitro experiments for validation. The cell proliferation, migration, invasion was then examined,...
Abstract Because of its high pathogenicity and infectivity, tuberculosis is a serious threat to human health. Some information about the functions genes in Mycobacterium genome was currently available, but it not enough explore transcriptional regulatory mechanisms. Here, we applied WGCNA (Weighted Gene Correlation Network Analysis) algorithm mine pooled microarray datasets for M. H37Rv strain. We constructed co-expression network that subdivided into 78 gene modules. The different response...
We have previously shown that ritonavir (RTV), a highly active anti-retroviral therapy (HAART) drug, can cause endothelial dysfunction through oxidative stress. Several antioxidants including ginsenoside Rb1, compound with antioxidant effect, effectively block this side effect of RTV in cells. In the current study, we explored mechanism by which Rb1 could protect these cells via binding estrogen receptors (ERs). found several human cell lines differentially expressed ER-β and had very low...
Non-coding RNA (ncRNA) is abundant in plant genomes, but poorly described with unknown functionality most species. Using whole genome sequencing, we identified 1885, 1910 and 1299 lncRNAs 186, 157 161 miRNAs at the level three Brassica species B. napus, oleracea rapa, respectively. The lncRNA sequences were divergent between One quarter of located tandem repeat (TR) region. expression both was strongly biased towards A rather than C subgenome unlike mRNA expression. genic regions had higher...
Circular RNAs (circRNAs) are closely associated with the development of non-small cell lung cancer (NSCLC); however, it is still unclear whether circular RNA circ-LDLRAD3 participated in regulation NSCLC progression. In this study, we found that was high-expressed and miR-137 low-expressed tissues cells compared to their normal counterparts, which showed negative correlations tissues. Further experiments validated could be sponged inhibited by cells. addition, knock-down overexpression...
Arrhythmia (ARR) is the defective origin and conduction of heart activity leading to an abnormal frequency rhythm heartbeats. ARR can cause chest tightness, weakness, sinoatrial node blockages, tachycardia even sudden death. ARR, therefore, seriously affects safety human life. An electrocardiogram (ECG) record changes in electrical produced each heartbeat cycle. Due its simplicity noninvasiveness, ECGs are used clinically diagnose ARRs. However, diagnosis by experts inefficient diagnostic...
ABSTRACT Chronic atrophic gastritis (CAG) is a precancerous lesion characterised by gastric mucosal atrophy and inflammation. Identifying key molecular mechanisms potential therapeutic targets essential to improve patient outcomes. Key modules differentially expressed genes (DEGs) were recognised in the GSE153224 dataset using weighted gene co‐expression network analysis (WGCNA) examination of differential expression. IGFBP7 was identified as hub protein–protein interaction (PPI) expression...
Introduction Ovarian cancer (OV) progression involves intricate interactions of genes and cellular pathways, with the ATP2A gene family recently emerging as significant. Material methods Through bioinformatic analysis, we evaluated expression prognostic impact in various cancers, emphasizing OV. Immunohistochemical clinical profiles ATP2A2 were subsequently analyzed OVs. We further explored effects ATP2A3 modulation on behaviors, involving proliferation, apoptosis, migration, invasion OV...
Polarization fatigue has remained a severe problem for the application of ferroelectric oxide in memories, sensors, and electric circuits due to limited understanding its underlying physics. This study identifies inhibited ferroelastic switching as primary driver polarization BiFeO3 thin films deposited on SrTiO3(110) substrates. Using voltage-biased piezo-response force microscopy, we observed pinning resulting from cyclic domain writing. unswitchable stems charged walls, stabilized by...
Antipsychotic drugs are limited in their ability to improve negative symptoms, quality of life, and medication adherence patients with schizophrenia. The addition nonpharmacological interventions like social skills training has a positive effect on decreases rehospitalization rates but is improving patients' aggressive behaviors, life. Aerobic exercise, especially Tai-chi, can potentially reduce psychopathological decrease It an ideal rehabilitation intervention for However, no study...
Clinical diagnosis of epilepsy significantly relies on identifying interictal epileptiform discharge (IED) in electroencephalogram (EEG). IED is generally interpreted manually, and the related process very time-consuming. Meanwhile, expert-biased, which can easily lead to missed misdiagnosis. In recent years, with development deep learning, algorithms have been used automatic EEG analysis, but there are still few attempts detection. This study uses currently most popular convolutional neural...
Background: Hepatic ischemia reperfusion injury (HIRI) is a common not only during liver transplantation but also major hepatic surgery. HIRI causes severe complications and affects the prognosis survival of patients. Cuproptosis, newly identified form cell death, plays an important role in variety illnesses. However, its remains unknown. Materials methods: The GSE151648 dataset was mined from Gene Expression Omnibus (GEO) database, differences were analyzed for intersections. Based on...