A5043798672- Prion Diseases and Protein Misfolding
- Animal Genetics and Reproduction
- Lymphoma Diagnosis and Treatment
- Neurological diseases and metabolism
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Salivary Gland Tumors Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Trace Elements in Health
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Bone Tumor Diagnosis and Treatments
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Oral and Maxillofacial Pathology
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
- Renal and related cancers
- Alzheimer's disease research and treatments
Yuhuangding Hospital
2020-2025
Qingdao University
2020-2025
Weifang People's Hospital
2018-2025
Weifang Medical University
2023-2024
Peking University
2004-2024
China-Japan Friendship Hospital
2024
Zhejiang Institute of Hydraulics & Estuary
2024
Longyan University
2018-2023
National Clinical Research Center for Digestive Diseases
2023
East China Normal University
2008-2020
Patients with advanced or metastatic esophageal squamous cell carcinoma (ESCC) have poor prognosis. For these patients, treatment options are limited after first-line systemic therapy.In this open-label phase III clinical study, patients ESCC, whose tumor progressed treatment, were randomly assigned (1:1) to receive intravenous tislelizumab, an anti-programmed death protein 1 antibody, 200 mg every 3 weeks chemotherapy (investigator's choice of paclitaxel, docetaxel, irinotecan). The primary...
1102 Background: MRG002 is a novel HER2-targeted ADC, composed of sugar-modified trastuzumab, MMAE payload and cleavable vc-linker. was effective in HER2-low expressing breast cancer preclinical studies. Hence, we conducted the phase II study to evaluate safety anti-tumor efficacy HER-low cancer. Methods: HER2 low tumor expression determined by central lab had be immunohistochemistry (IHC)1+ or 2+/ISH-. Eligible patients advanced/metastatic that failed standard therapies. administered...
9114 Background: TROP2 (trophoblast cell surface antigen 2) is commonly overexpressed in non-small lung cancer (NSCLC) and associated with poor prognosis. SKB264 a novel anti-TROP2 ADC developed using sulfonyl pyrimidine-CL2A-carbonate linker to conjugate its payload, belotecan-derivative topoisomerase I inhibitor, achieve an average Drug-to-antibody Ratio (DAR) of 7.4. The design was more effective balance between stability circulation release the payload tumor cells. Here we report...
In order to perform their normal physiological functions, it is important that cells maintain the intracellular pH within range. Intracellular enzyme activity, cytoskeleton component integration, and cellular growth differentiation rates are all closely associated with pH. It has been demonstrated in nervous system diseases, such as ischemic stroke, traumatic brain injury, epilepsy, Parkinson's disease, Alzheimer's disease (AD), common characteristics decreased or acidosis at both tissular...
The autosomal dominant spinocerebellar ataxias (SCAs) are a genetically heterogeneous group of disorders exhibiting cerebellar atrophy and Purkinje cell degeneration whose subtypes arise from 31 distinct genetic loci. Our previously published the locus for SCA26 on chromosome 19p13.3. In this study, we performed targeted deep sequencing critical interval in order to identify candidate causative variants individuals family. We identified single variant that co-segregates with disease...
The prion hypothesis is strongly supported by the fact that infectivity and pathogenic conformer of protein (PrP) are simultaneously propagated in vitro serial misfolding cyclic amplification (sPMCA). However, due to sPMCA's enormous power, whether an infectious can be formed de novo with bacterially expressed recombinant PrP (rPrP) remains satisfactorily resolved. To address this question, we performed unseeded sPMCA rPrP a laboratory has never been exposed any native prions. Two types...
The cellular prion protein (PrP C ), a membrane glycoprotein anchored to the outer surface of neurons, lymphocytes and other cells, is associated directly with pathogenesis transmissible spongiform encephalopathies (TSEs) occurring mainly in humans, cattle, sheep goats. Although mice lacking PrP develop reproduce normally are resistant scrapie infection, large animals , especially those species which TSE occurs naturally, currently not available. Here, five live PRNP +/− goats cloned by gene...
Androgen signaling plays an important role in many biological processes. Responsive Gene Database (ARGDB) is devoted to providing integrated knowledge on androgen-controlled genes. records were collected the basis of PubMed literature collections. More than 6000 abstracts and 950 original publications manually screened, leading 1785 human genes, 993 mouse 583 rat genes finally included database. All experimentally proved be regulated by androgen at expression level or contain...
Abstract Because of its high pathogenicity and infectivity, tuberculosis is a serious threat to human health. Some information about the functions genes in Mycobacterium genome was currently available, but it not enough explore transcriptional regulatory mechanisms. Here, we applied WGCNA (Weighted Gene Correlation Network Analysis) algorithm mine pooled microarray datasets for M. H37Rv strain. We constructed co-expression network that subdivided into 78 gene modules. The different response...
424 Background: This study evaluated the strategy of dose-dense chemotherapy plus a PD-1 inhibitor with selective organ-preservation in patients advanced esophageal squamous cell carcinoma (ESCC). Methods: Patients locally or metastatic (confined to supraclavicular lymph nodes) ESCC were enrolled receive treatment albumin bound-paclitaxel, cisplatin and 5-FU every two weeks. After six cycles treatment, clinical complete response (cCR) confirmed by computed tomography (CT), endoscopy biopsy...
Background To evaluate the efficacy and safety of sintilimab in combination with trastuzumab chemotherapy for HER2-positive advanced gastric/gastroesophageal junction cancer (GC/GEJC). Methods GC/GEJC patients admitted to our department between January 2018 October 2024 were included this study. Patients who received assigned cohort A, while alone B. The primary endpoints progression-free survival (PFS) overall (OS), secondary disease control rate (DCR), objective response (ORR), safety....
Background Pleural effusion (PE) caused by lung cancer is prevalent, and it difficult to differentiate from PE tuberculosis. Exosome-based liquid biopsy offers a non-invasive technique diagnose benign malignant PE. Exosomal miRNAs are potential diagnostic markers play an essential role in signal transduction biological processes tumor development. We hypothesized that exosomal miRNA expression profiles would contribute identifying its elucidating the molecular basis of formation cancer....
Tight junction plays an important role in mediating paracellular permeability epithelia. We previously found that activation of AMP-activated protein kinase (AMPK) increased saliva secretion by modulating submandibular glands. However, the molecular mechanisms underlying AMPK-modulated are unknown. In this study, we AICAR, AMPK agonist, isolated rat glands, decreased transepithelial electrical resistance (TER), and 4 kDa FITC-dextran flux cultured SMG-C6 cells. AICAR also induced...