A5101457887- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Folate and B Vitamins Research
- Nutritional Studies and Diet
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- RNA Interference and Gene Delivery
- Glycosylation and Glycoproteins Research
- Drug Transport and Resistance Mechanisms
- Advanced biosensing and bioanalysis techniques
- Peptidase Inhibition and Analysis
- Breast Cancer Treatment Studies
- Medicinal Plant Pharmacodynamics Research
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Nutrition and Health in Aging
- IgG4-Related and Inflammatory Diseases
- Circadian rhythm and melatonin
- Kruppel-like factors research
- Iron Metabolism and Disorders
Nanjing Medical University
2013-2024
Jiangsu Province Hospital
2022-2024
Dalian Medical University
2023
First Affiliated Hospital of Dalian Medical University
2023
Nanjing University of Chinese Medicine
2014-2021
Jiangsu Cancer Hospital
2007-2017
Pyrotinib (an irreversible pan-ErbB inhibitor) plus capecitabine has survival benefits and acceptable tolerability in patients with HER2-positive metastatic breast cancer. We further assessed addition of pyrotinib to trastuzumab docetaxel the neoadjuvant setting. In this multicenter, double-blind, phase 3 study (PHEDRA), treatment-naive women early or locally advanced cancer were randomly assigned (1:1) receive four cycles oral placebo (400 mg) once daily, intravenous (8 mg/kg loading dose,...
1102 Background: MRG002 is a novel HER2-targeted ADC, composed of sugar-modified trastuzumab, MMAE payload and cleavable vc-linker. was effective in HER2-low expressing breast cancer preclinical studies. Hence, we conducted the phase II study to evaluate safety anti-tumor efficacy HER-low cancer. Methods: HER2 low tumor expression determined by central lab had be immunohistochemistry (IHC)1+ or 2+/ISH-. Eligible patients advanced/metastatic that failed standard therapies. administered...
Pregnane X receptor (PXR) is a member of the nuclear superfamily ligand‑regulated transcription factors. PXR key xenobiotic that regulates expression genes implicated in drug metabolism, detoxification and clearance, including metabolizing enzymes transporters, suggesting it significant resistance cancer cells. expressed wide range tissues human body. Studies have demonstrated variety tumor types, correlating not only with but also cell proliferation, apoptosis prognosis cancer. The purpose...
Breast cancer is the second leading cause of cancer‑related mortality in females worldwide. Therefore, identifying alternative strategies to combat disease important. The aim present study was investigate effect tanshinone I (Tan I) on tumorigenicity estrogen‑responsive MCF‑7 and estrogen‑independent MDA‑MB‑453 human breast cells. cytotoxicity Tan evaluated using a Cell Counting Kit‑8 assay, apoptosis cell cycle distribution were detected flow cytometry morphology observed fluorescence...
Obesity is a consideration in the pharmacologic intervention for estrogen receptor (ER) positive (ER+) breast cancer risk. Body mass index (BMI) and waist/hip ratio (WHR) have demonstrated different effects on risk relation to status, but results been inconsistent. Furthermore, situation Chinese women remains unclear.We conducted case-control study including 1,439 cases Northern Eastern China. Both ER progesterone (PR) statuses were available 1,316 cases. Associations between body...
To evaluate the relationship between alcohol drinking, XRCC1 codon 194 and 399 polymorphisms risk of colorectal cancer, we conducted a case-control study with 315 cancer cases (105 colon, 210 rectal) 439 population-based controls in Jiangsu Province China. The genotypes were identified using polymerase chain reaction restrictrion fragment length polymorphism methods (PCR-RFLP). A structured questionnaire was used to elicit detailed information. Odds ratios (ORs) estimated an unconditional...
It has previously been reported that KU60019, as a highly effective radiosensitizer, inhibits the DNA damage response and blocks radiation-induced phosphorylation of key ataxia telangiectasia mutated targets in human glioma cells. The present study investigated whether KU60019 affects cell physiological activities strengthens efficacy doxorubicin-induced damage. was demonstrated compound suppressed proliferation MCF-7 cells significantly increased chemosensitization. In addition, (without...
To evaluate the relationship between abortions and risk of breast cancer, we conducted a case-control study with 669 cases 682 population-based controls in Jiangsu Province China. A structured questionnaire was used to elicit detailed information. Unconditional logistic regression analysis performed calculate odds ratios (ORs) 95% confidence intervals (CIs). The results have revealed that induced abortion related increased caner. Premenopausal women who had <TEX>${\geq}3$</TEX> times were at...
The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature.Here, we report unique case of IMT coexisting breast cancer. Modified radical mastectomy was performed, followed by TAC chemotherapy (taxotere, adriamycin and cyclophosphamide). At 2-year follow-up, patient continues to be disease free.At preoperative stage, definitive diagnoses masses are extremely difficult; surgery advised after diagnosis confirmed pathological...
Background Inflammation is one of the major hallmarks cancer. This study was designed to profile a panel inflammatory mediators in gastric adenocarcinoma (GA) and identify their potential differences separately metastatic non-metastatic patient subgroups. Methods Serum samples from 216 GA patients 333 healthy controls China were analyzed for six proteins using Luminex multiplex assay. Results The serum levels all significantly elevated compared GA. Two acute phase (SAA CRP) CXC chemokine...
Abstract Background Cationic polymers are outstanding representatives of the most efficient small interfering RNA (siRNA) vectors. Low cytotoxicity and siRNA protecting effect can be obtained with these cationic via a variety structural modifications. Nevertheless, gap between their efficiency requirement for therapeutic processes is still noticeable. Methods A polymer vector was synthesized copolymerization N ‐(1,3‐dihydroxy propan‐2‐yl)methacrylamide (DHPMA) ‐(3‐aminopropyl)methacrylamide...