A5101796265- Kruppel-like factors research
- MicroRNA in disease regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal and related cancers
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
- Economic Zones and Regional Development
- Gastric Cancer Management and Outcomes
- Safety and Risk Management
- Pancreatic and Hepatic Oncology Research
- Curcumin's Biomedical Applications
- 3D Modeling in Geospatial Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Microscopic Colitis
- Spatial and Panel Data Analysis
- Regional Economic and Spatial Analysis
- Wnt/β-catenin signaling in development and cancer
- RNA regulation and disease
Huazhong Agricultural University
2025
Nanjing Drum Tower Hospital
2021-2024
Tongren Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2023
Qiqihar Medical University
2021-2023
Institute of Hematology & Blood Diseases Hospital
2023
Shenzhen Institute of Information Technology
2022
Nanjing University
2020-2021
State Key Laboratory of Pharmaceutical Biotechnology
2020-2021
South Central Minzu University
2019-2021
Abstract During cold exposure, activated brown adipose tissue (BAT) takes up a large amount of circulating glucose to fuel non-shivering thermogenesis and defend against hypothermia. However, little is known about the endocrine function BAT controlling homoeostasis under this thermoregulatory challenge. Here, we show that in male mice, BAT-derived extracellular vesicles (BDEVs) reprogram systemic metabolism by promoting hepatic gluconeogenesis during stress. Cold exposure facilitates...
The heterogeneities of colorectal cancer (CRC) lead to staging inadequately patients' prognosis. Here, we performed a prognostic analysis based on the tumor mutational profile and explored characteristics high-risk tumors. We sequenced 338 carcinomas as training dataset, constructed novel five-gene (SMAD4, MUC16, COL6A3, FLG LRP1B) signature, validated it in an independent dataset from Cancer Genome Atlas (TCGA). Kaplan-Meier Cox regression analyses confirmed that signature is predictor...
Novel therapeutic agents including disitamab vedotin (RC48, an antibody-drug conjugate) and immune-checkpoint inhibitors (e.g., PD-1 inhibitors) have provided new hope as advanced gastric-cancer (GC) treatment. This multicenter retrospective study studied RC48 monotherapy (MT)'s efficacy safety against its combination with anti-PD-1 immunotherapy (IT) in GC. Patients treated MT or combined IT from July 2021 to April 2023 were recruited for the study. The progression-free survival (PFS),...
Bisdemethoxycurcumin (BDMC) is an active component of curcumin and a chemotherapeutic agent, which has been suggested to inhibit tumor growth, invasion metastasis in multiple cancers. But its contribution mechanism action non-small cell lung cancer (NSCLC) are not very clear. Therefore, we tried study the effects BDMC on regulation epithelial-to-mesenchymal transition (EMT), closely linked metastasis. In this study, first induced transforming growth factor-β1 (TGF-β1) mediated EMT highly...
Genistein, a flavonoid, is one of the main components soybeans. It was shown to alleviate contact dermatitis through inhibition allergen-induced activation MAP2K2 in keratinocytes.
Curcumin is an active component of the medicinal plant turmeric, which has been reported to have anti‑metastatic activities and induce autophagy in numerous cancer types. Bisdemethoxycurcumin (BDMC), one major curcumin derivatives present was previously shown trigger highly metastatic large‑cell lung 95D cells. However, effects induction by BDMC on invasion migration cells remained elusive. Therefore, study investigated Meanwhile we observed effect induced Transwell assays showed that...
A population-based case-control study to determine social and behavioural risk factors for Taenia solium cysticercosis in humans was carried out a rural area, Shandong province, China. Forty-eight cases with were ascertained through prevalence survey conducted among 7281 persons 1993. For each case, four controls residing the same village matched age sex randomly selected. Information regarding demographic, collected during house visits interviews direct observation. Risk strongly associated...
Rationale: Targeting vascular smooth muscle cell (VSMC) phenotypic switching is a promising therapeutic approach for atherosclerosis. Dysregulation of PGC1α (peroxisome proliferator-activated receptor gamma, coactivator 1α), key regulator cellular energy metabolism, has been implicated in the pathogenesis atherosclerosis, yet its role atherosclerosis remains controversial. Objective: The current study aimed to determine whether and how VSMCs regulates progression. Methods Results: We...
Epigenetic modifications serve important roles in non-small cell lung cancer (NSCLC) tumorigenesis; however, the role of DNA methyltransferase 1 (DNMT1) progression remains unclear. In present study, expression DNMT1 human NSCLC lines 95D (high invasive ability) and 95C (low was analyzed by western blotting. The results demonstrated that cells significantly higher, compared with small airway epithelial cells. To further define tumor migration invasion cells, RNA interference used to silence...