A5100337098- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Muscle metabolism and nutrition
- Obstructive Sleep Apnea Research
- Diet and metabolism studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nutrition and Health in Aging
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Fatty Acid Research and Health
- GDF15 and Related Biomarkers
- Adenosine and Purinergic Signaling
- Dietary Effects on Health
- Climate Change and Health Impacts
- Regulation of Appetite and Obesity
- Hypothalamic control of reproductive hormones
- Reproductive System and Pregnancy
- Nutrition, Genetics, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tea Polyphenols and Effects
Renmin Hospital of Wuhan University
2024
Nanjing University
2016-2024
Wuhan University
2024
Air Force Medical University
2024
Xijing Hospital
2024
Liaoning Normal University
2022-2023
Nanjing Drum Tower Hospital
2023
Sichuan Agricultural University
2023
Ministry of Education of the People's Republic of China
2023
Shenyang Sport University
2021-2023
Abstract Visceral adiposity is strongly associated with metabolic disease risk, whereas subcutaneous comparatively benign. However, their relative physiological importance in energy homeostasis remains unclear. Here, we show that after 24-h fasting, the adipose tissue of mice acquires key properties visceral fat. During this fast-induced ‘visceralization’, upregulation miR-149-3p directly targets PR domain containing 16 (PRDM16), a coregulatory protein required for ‘browning’ white In...
Abstract During cold exposure, activated brown adipose tissue (BAT) takes up a large amount of circulating glucose to fuel non-shivering thermogenesis and defend against hypothermia. However, little is known about the endocrine function BAT controlling homoeostasis under this thermoregulatory challenge. Here, we show that in male mice, BAT-derived extracellular vesicles (BDEVs) reprogram systemic metabolism by promoting hepatic gluconeogenesis during stress. Cold exposure facilitates...
The global rise in obesity and type 2 diabetes has precipitated the need for therapeutic intervention arsenal against adiposity.
The enrichment of peri-cancerous adipose tissue is a distinctive feature colorectal cancer (CRC), accelerating disease progression and worsening prognosis. communication between tumor cells adjacent adipocytes plays crucial role in CRC advancement. However, the precise regulatory mechanisms are largely unknown. This study aims to explore mechanism migration invasion inhibitory protein (MIIP) downregulation remodeling cell-adipocyte its promoting CRC. MIIP expression was found be decreased...
Rare reports can be found about sex- and age-specific body composition survey among Chinese population. The aim of this study is to explore the change with aging in males females respectively. present cross-sectional was carried out Central South University Xiangya School Medicine Affiliate Haikou Hospital, on a random sample consisting 5121 participants. Inbody720 analyzer used detect human composition. Data collection based assessment anthropometric measurements done help bioelectric...
The study aimed to explore the role of irisin receptor (integrin αVβ5) signaling pathway in obesity-induced osteoporosis and its potential mechanism. integrin αVβ5 gene bone marrow mesenchymal stem cells (BMSCs) was silenced overexpressed, were exposed treatment mechanical stretch. Mouse models obesity established by feeding mice a high-fat diet, 8-week caloric restriction/aerobic exercise regimens implemented. results showed that after silencing αVβ5, osteogenic differentiation BMSCs...
Abstract Background Energy balance is closely related to reproductive function, wherein hypothalamic kisspeptin mediates regulation of the energy balance. However, central mechanism in male function under different states unclear. Here, high-fat diet (HFD) and exercise were used change explore role leptin inflammation hypothalamic-pituitary-testis (HPT) axis. Methods Four-week-old C57BL/6 J mice randomly assigned a normal control group ( n = 16) or an HFD 49) group. After 10 weeks feeding,...
FAM3A plays important roles in regulating hepatic glucose/lipid metabolism and the proliferation of VSMCs. This study determined role mechanism adipogenesis 3T3-L1 preadipocytes. During preadipocytes, expression was significantly increased. overexpression enhanced preadipocyte with increased phosphorylated Akt (pAkt) level, whereas silencing inhibited reduced pAkt level. Moreover, secretion adipokines cells. protein is mainly located mitochondrial fraction cells mouse adipose tissue....
Dietary trans -10, cis -12-conjugated linoleic acid ( -12-CLA) fed to obese and nonobese rodents reduces body fat but leads greater liver mass due steatosis. The molecular mechanisms accompanying such responses remain largely unknown. Our study investigated the effects of chronic low -12-CLA supplementation on hepatic expression 39 genes related metabolism, inflammation, stress in growing mice. Feeding a diet supplemented with 0.3% (wt/wt basis) for 6 weeks increased concentration long-chain...
Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes (T2DM). Decreased mitochondrial abundance function were found in white adipose tissue (WAT) of T2DM patients. Therefore, promoting WAT biogenesis improving adipocyte metabolism may be strategies to prevent reverse T2DM. Salvianolic acid A (SAA) has been exert anti-diabetic lipid disorder-improving effects. However whether SAA benefits unclear. Here, we evaluated SAA's effect on 3T3-L1 adipocytes investigated...
Background Obesity is a growing problem worldwide, and newer therapeutic strategies to combat it are urgently required. This study aimed analyze the effect of diet exercise interventions on energy balance in mice elucidate mechanism peroxisome proliferator-activated receptor-gamma co-activator-1-alpha-IRISIN-uncoupling protein-1 (PGC-1α-IRISIN-UCP-1) pathway beigeization white adipose tissue. Methods Four-week-old male C57BL/6 were randomly divided into normal (NC) high-fat (HFD) groups....
To understand the long-term metabolic and functional consequences of increased GLUT4 content, intracellular substrate utilization was investigated in isolated muscles transgenic mice overexpressing selectively fast-twitch skeletal muscles. Rates glycolysis, glycogen synthesis, glucose oxidation, free fatty acid (FFA) oxidation as well content were assessed EDL (fast-twitch) soleus (slow-twitch) from female male MLC-GLUT4 control mice. In EDL, influx predominantly led to glycolysis. contrast,...
Abstract Objective To evaluate the longitudinal correlations between sulfatide/lysosulfatide levels and central peripheral nervous system function in children with metachromatic leukodystrophy (MLD) to explore impact of intravenous recombinant human arylsulfatase A (rhASA) treatment on myelin turnover. Methods Phase 1/2 study rhASA investigated cerebrospinal fluid (CSF) sural nerve sulfatide levels, 88‐item Gross Motor Function Measure (GMFM‐88) total score, sensory motor conduction, brain N...
Abstract The fatty acid composition of the membrane phospholipids phosphatidylcholine (PC) and phosphatidylethanolamine in insulin‐sensitive Type I (soleus) insulin‐resistant II (EDL) muscle is not known. In present studies, soleus EDL muscles were removed from 250–300 g Sprague‐Dawley rats, total individual phospholipid (PL) species was quantitated. As expected, triglyceride content increased twofold muscle. No quantitative differences PL or cholesterol found between two muscles. However, a...
The global rise in obesity has become a public health crisis. During the onset of obesity, disrupted catecholamine signals have been described to contribute excess fat accumulation, however, molecular and metabolic change subcutaneous adipose tissue (SAT) upon chronic high-fat feeding rarely investigated. Here, we show that caused significant decrease expression thermogenic genes acquisition partial deleterious features visceral SAT. Upregulated miR-149-3p was involved this obesity-induced...
Knowledge about the mouse brown adipose tissue (BAT) proteome can provide a deeper understanding of function mammalian BAT. Herein, comprehensive analysis interscapular BAT from C57BL/6J female mice was conducted by 2DLC and high-resolution mass spectrometry to construct dataset proteins. A total 4949 nonredundant proteins were identified, 4495 quantified using iBAQ method. According values, divided into high-, middle- low-abundance The functions high-abundance mainly related glucose fatty...