Aims To evaluate the concurrent use of vancomycin and ε-aminocaproic acid (EACA) in primary total hip arthroplasty (THA). Methods In total, 120 patients undergoing unilateral THA were divided into three groups: Group VE received intra-articular EACA; V only vancomycin; E EACA. Blood joint fluids sampled postoperatively to measure levels using chromatography. loss kidney function monitored. Results Groups had equivalent blood loss, which was less than that V. Intra-articular higher at all...

The efficacy of prophylactic cranial irradiation (PCI) is still controversial in small cell lung cancer (SCLC) patients with pT1-2N0M0 disease after complete resection. majority previous studies haven't discerned the potential benefit PCI this subgroup patients, probably due to paucity these and distinct treating modalities. aim study demonstrate medical patients. A retrospective was conducted evaluate SCLC We retrospectively reviewed 112 SCLCs resection adjuvant chemotherapy between January...

To explore the extent and nature of television food advertising especially unhealthy to primary school children in Xi'an, China.Television data were recorded for 2 weekdays weekend days between 6:00 22:00 during May June 2012 from a total five channels most popular with Xi'an. Pearson χ (2) tests logistic regression applied determine differences proportion healthy food, miscellaneous advertisements different channels, programs, dates, viewing periods use persuasive marketing tactics.Of 5527...

Mitochondrial dysfunction is associated with insulin resistance and type 2 diabetes (T2DM). Decreased mitochondrial abundance function were found in white adipose tissue (WAT) of T2DM patients. Therefore, promoting WAT biogenesis improving adipocyte metabolism may be strategies to prevent reverse T2DM. Salvianolic acid A (SAA) has been exert anti-diabetic lipid disorder-improving effects. However whether SAA benefits unclear. Here, we evaluated SAA's effect on 3T3-L1 adipocytes investigated...

To investigate the preventive effect of intraarticularly administered vancomycin on acute postoperative periprosthetic joint infection (PJI) in total arthroplasty (TJA).Consecutive patients who underwent unilateral primary TJA were prospectively enrolled. The divided into group and control according to whether 1 g powder suspended 30 ml normal saline was after arthrotomy closure. Acute PJI aseptic wound complication evaluated within 3 months postoperatively. Vancomycin-associated toxicity...

Abstract Carcinogenesis is an exceedingly complicated process, which involves multi-level dysregulations, including genomics (majorly caused by somatic mutation and copy number variation), DNA methylomics transcriptomics. Therefore, only looking into one molecular level of cancer not sufficient to uncover the intricate underlying mechanisms. With abundant resources public available data in Cancer Genome Atlas (TCGA) database, integrative strategy was conducted systematically analyze aberrant...

The present study aimed to explore the clinical value of color Doppler ultrasound combined with serum tumor markers, including calcitonin (CT) and carcinoembryonic antigen (CEA), for diagnosis medullary thyroid carcinoma (MTC). A total 39 patients MTC (MTC group), 50 papillary (PTC) (PTC group) 30 adenoma (benign control were enrolled in study. hospitalized at Affiliated Hospital Qingdao University from January 2012 December 2018 diagnosed through surgical procedures pathology laboratory...

A routine pipeline seems very common in many cancer studies that expression differentiation might be helpful identifying prognostic molecules. There also exists a striking unanimity molecules upregulated usually shorten survival, while downregulated ones have the opposite effect. In this study, based on transcriptional profiles of 18 malignancies, and corresponding adjacent normal tissues were used to calculate differential scores. Cox correlation coefficients global genes calculated denote...

High-dose radioactive iodine (RAI) is recommended for patients with nonmetastatic differentiated thyroid cancer macroscopic extrathyroidal extension (MAEE). It unclear whether these can be treated low-dose RAI when preablative-stimulated thyroglobulin (ps-Tg) low. This randomized study aims to evaluate the clinical outcome and ablative efficacy of radioiodine in MAEE but low ps-Tg level.Differentiated complete thyroidal resection, MAEE, any N stage, less than or equal 5 ng/ml antibodies are...

Related studies have reported that cystatin C (Cys C), uric acid (UA) and lactate dehydrogenase (LDH) affect tumor growth invasion; however, the correlation between them prognosis of patients with small‑cell lung cancer (SCLC) remains unclear. The present study aimed to investigate effects serum Cys C, UA LDH concentrations on SCLC prior initial treatment, in order identify potential targets for determining clinical outcome SCLC. A total 205 were enrolled study, laboratory data obtained from...

This study aimed to find the prognostic factors of local advanced gastric cancer patients with adjuvant concurrent chemoradiotherapy after radical D2 gastrectomy, and explore value lymph node ratio (LNR).We retrospectively analyzed 164 enrolled in West China Hospital from 2006 2013, who underwent gastrectomy chemoradiotherapy. With univariate analysis Cox regression model, we evaluated association LNR other clinical pathological characteristics overall survival (OS) relapse-free (RFS)...

A tumor can be perceived as a special "organ" that undergoes aberrant and poorly regulated organogenesis. Embryonic development carcinogenesis share striking similarities in their cellular behavior underlying molecular mechanisms. This intimate association makes embryonic viable reference model for studying cancer thereby circumventing the potentially misleading complexity of heterogeneity. Therefore, on basis global expression profile, genes simultaneously activated (up-regulated terms...

Colorectal cancer is a complex multistage process following the adenoma-carcinoma sequence. Additional research on basis of molecular dysregulations, particularly in precancerous stage, may provide insight into realization potential biomarkers and therapeutic targets for disease. In present study, expression profile human colorectal mucosa tissues, including healthy, adenoma adenocarcinoma samples, was downloaded. Genes that were consistently differentially expressed tissues samples...

Chemoresistance is the primary cause of poor outcome glioblastoma multiforme (GBM) therapy. Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) involved in growth and proliferation several types cancer, including gastric cancer ovarian cancer. Therefore, aim present study was to investigate role LGR6 GBM malignancy chemoresistance. Cell counting kit-8 Matrigel®-Transwell assays were conducted assess cell viability invasion. The effect on cycle progression activation Akt...

e13590 Background: Immunotherapy is becoming one of the promising treatments for cancer administration, and several studies indicated a better outcome was received in patients with high tumor mutation burden (TMB). The distribution TMB still unknown this study aimed to analysis association between age especially East Asian populations. Methods: In our study, value measured as numbers synonymous, nonsynonymous mutations InDels by next generation sequencing 539 genes panel tissue. TMB-H...

The relentless debate on postoperative adjuvant radiotherapy in gastric adenocarcinoma (GA) has been lasting for decades. In this study, a new biomarker, named promoter methylation burden of DNA repair genes (RPMB), was established to identify the subgroup patients who might benefit from radiotherapy. Methylation profiles 397 GA tumor samples were downloaded Cancer Genome Atlas (TCGA). RPMB patient defined as ratio methylated number all genes. Subgroup analyses term overall survival (OS) and...

Introduction The efficacy of postoperative radiotherapy (PORT) is still unclear in non-small cell lung cancer (NSCLC) patients with pIIIA-N2 disease. Estrogen receptor (ER) was proven significantly associated poor clinical outcome male squamous (LUSC) after R0 resection our previous study. Methods A total 124 LUSC who completed four cycles adjuvant chemotherapy and PORT complete were eligible for enrollment this study from October 2016 to December 2021. ER expression evaluated using...

Aggressive angiomyxoma (AAM) is rare.AAM characterized by invasion and recurrence.Improving the detection rate of AAM through ultrasonic inspection technology.There very little literature reported on AAM.And performance rare.Therefore, this article describes ultrasound manifestation a 54-year-old woman whose pathology confirmed to be AAM, summarizes common manifestations AAM.The unique feature that does not explore typical "vortex".So we need diagnose case other findings.The patient...