A5050560960- Weed Control and Herbicide Applications
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Enhanced Oil Recovery Techniques
- Hydraulic Fracturing and Reservoir Analysis
- Pesticide and Herbicide Environmental Studies
- Cancer Mechanisms and Therapy
- Allelopathy and phytotoxic interactions
- MicroRNA in disease regulation
- RNA modifications and cancer
- Genetic factors in colorectal cancer
- Plant tissue culture and regeneration
- Circular RNAs in diseases
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
- Drilling and Well Engineering
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Hydrocarbon exploration and reservoir analysis
- Angiogenesis and VEGF in Cancer
Hebei Academy of Agriculture and Forestry Sciences
2009-2024
First Affiliated Hospital of Hebei Medical University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
China University of Petroleum, Beijing
2022-2023
Hebei Medical University
2016-2022
Shanxi Agricultural University
2015
Ordnance Engineering College
2013
Guangxi Medical University
2013
Wan Fang Hospital
2013
Integrin β4 (ITGB4) has been reported to be involved in carcinomas. Currently, ITGB4 characterized colon cancer, however, its clinical significance is not very clear. In the present study, we utilized large public datasets from NCBI Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases collected samples our center investigate transcriptional expressions of then explored associations with clinicopathological features overall survival. statistical analyses suggested that...
Colorectal cancer (CRC) is one of the most common malignancies and has been a leading cause cancer-related death worldwide in recent years. N6-methyladenosine (m6A) methylation abundant epigenetic modification various types RNAs, it plays vital role promoting development. Here, we obtained SNV transcriptome data CRC from The Cancer Genome Atlas (TCGA). We demonstrated that m6A regulators were aberrantly expressed individuals with CRC. abnormal expression was caused by their different copy...
Background: Colorectal cancer (CRC) is the most common gastrointestinal malignancy. And probiotics may have function of preventing colon cancer. The aim this study was to investigate inhibitory effects a probiotic mixture on colorectal and its potential mechanisms. Methods: proliferation metastasis mouse CT26 cells were assessed by co-culture assay, Cell Counting Kit-8 colony formation wound-healing as well migration invasion assays. also transplanted into BALB/c mice construct tumor animal...
Rationale: The prevalence of obesity and its associated complications is on the rise globally. Bariatric surgery has proven to be a very effective method induce sustained weight loss as well reduce obesity-related diseases, such type 2 diabetes, hypertension hyperlipemia. Patient concerns: 30-year-old female patient, with BMI at 79.2 kg/m abdominal circumference 199 cm, gained continually, felt chest tightness shortness breath for 10 days. Diagnoses: patient was diagnosed severe complicated...
High-performance CO2-improved oil recovery (IOR) and storage technology is one of the most promising measures for global oilfield companies to achieve zero carbon targets. Due severe heterogeneity petroleum reservoirs significant density difference between CO2 reservoir fluid, efficiency CO2-IOR usually limited. In this paper, a high-temperature high-pressure 30 cm core displacement experiment was used study conformance control performance both single- combined plugging system in long...
Postemergence applications of nicosulfuron can cause great damage to certain maize inbred lines and hybrids. Variation among different responses may be attributed differential rates herbicide metabolism. We employed RNA-Seq analysis compare transcriptome between nicosulfuron-treated untreated in both tolerant susceptible plants. A total 71.8 million paired end Illumina reads were generated, representing the transcription around 40,441 unique reads. About 345,171 gene ontology (GO) term...
Abstract Objectives SATB 2 has been shown to be markedly reduced in colorectal cancer ( CRC ) tissues relative paired normal controls; however, the mechanism behind remains not well understood. To investigate why was down‐regulated , we attempted analyse it from angle of mi RNA ‐ mRNA modulation. Materials and methods expression detected using immunohistochemistry verified real‐time PCR on level, followed by analysis clinicopathological significance its expression. Metastatic variation cells...
Nanoparticles have recently been widely used in polymer gel systems to enhance strength. However, it is yet unclear how various types of nanoparticles affect the gelation characteristics gels. In addition, nanomaterials are rarely studied for enhancing temperature resistance polyethyleneimine (PEI) cross-linked polyacrylamide gels (i.e., HPAM/PEI gels). Under urgent requirements global carbon neutrality, this paper intends use nanofibers as performance-enhancing materials. Furthermore,...
Lithologic reservoirs, such as conglomerate exhibit stronger heterogeneity compared with conventional sandstone reservoirs. Their early stage development usually requires hydraulic fracturing to increase the stimulated reservoir volume (SRV). As a result, high-conductivity channels are generated during waterflooding, which further limit sweep and oil recovery. Traditional particle gels in situ cross-linked polymer limited field application due their low plugging strength. In this paper,...
Purpose: We recently reported that tripartite motif-containing 67 (TRIM67) activates p53 to suppress colorectal cancer (CRC). However, the function and mechanism of TRIM67 in inhibition CRC cell proliferation metastasis remains be further elucidated. Methods: detected expression tissues compared with normal confirmed its relationship clinicopathological features. DNA methylation was analyzed determine significantly hypermethylated sites tissues. CCK-8, colony formation, transwell migration,...
Immune response-related genes play a major role in colorectal carcinogenesis by mediating inflammation or immune-surveillance evasion. Although remarkable progress has been made to investigate the underlying mechanism, understanding of complicated process was enormously hindered large-scale tumor heterogeneity. Development and share striking similarities their cellular behavior molecular mechanisms. The association between embryonic development makes viable reference model for studying...
Colorectal cancer (CRC) is the third most common tumor in world; however, role and mechanism of endoplasmic reticulum (ER) stress CRC metastasis remains largely unclear. Metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1) a long non‑coding RNA (lncRNA), which has previously been associated with metastasis. It suggested that ER pathways regulate lncRNA expression; effect on MALAT1 expression unknown. The present study aimed to investigate relationship between pathways, cell...
The tumor microenvironment (TME) has significantly correlation with occurrence and prognosis. Our study aimed to identify the prognostic immune-related genes (IRGs)in of colorectal cancer (CRC).Transcriptome clinical data CRC cases were downloaded from TCGA GEO databases. Stromal score, immune purity calculated by ESTIMATE algorithm. Based on scores, we divided patients database into low high groups, differentially expressed (DEGs) identified. Immune-related (IRGs) selected venn plots. To...
Foxtail millet is an important characteristic grain crop in northern China. However, weeds compete seriously with foxtail and have long been a biological factor that has plagued production. Rotation requires determining the species sequence of crops, reasonable rotation many benefits for agriculture, including reducing damage by weeds. In order to clarify combination effects millet–soybean herbicide on weed control yield, fixed-position experiments were designed three growing seasons....
Postemergence application of nicosulfuron for weed control in maize fields can cause great damage to certain inbred lines and hybrids. Two genotypes, tolerant (HBR) sensitive (HBS), were found significantly differ their phenotypic responses nicosulfuron, with the EC50 (50% effective concentration) values differed statistically (763.6 5.9 g a.i. ha–1, respectively). Pre-treatment malathion, a known cytochrome P450 inhibitor, increased injury both HBR HBS. Our results support hypothesis that...
<p class="Abstract">The aim of the present investigation was to examine and demonstrate in detail anti-cancer apoptotic effects daucosterol human colon cancer cell line HCT-116. The this compound on migration, invasion, cycle analysis caspase signalling pathway were also studied. Cell viability evaluated by MTT assay using different doses drug. In vitro wound healing used study migration. Flow cytometry involved apoptosis as well phase distribution. Daucosterol induced significant,...
Abstract Carcinogenesis is an exceedingly complicated process, which involves multi-level dysregulations, including genomics (majorly caused by somatic mutation and copy number variation), DNA methylomics transcriptomics. Therefore, only looking into one molecular level of cancer not sufficient to uncover the intricate underlying mechanisms. With abundant resources public available data in Cancer Genome Atlas (TCGA) database, integrative strategy was conducted systematically analyze aberrant...
Cysteine-rich protein 61 (CYR61) and metastasis associated in colon cancer (MACC1) promoted human colorectal (CRC) cell closely related to the patient's prognosis cancer. The purpose of this article is investigate whether CYR61 MACC1 can serve as dual potential targets for gene therapy CRC. In study, microRNA (miRNA) targeting both was used mechanism therapeutic effects CRC cells mice with We observed that silencing miRNA inhibited epithelial-mesenchymal transition (EMT) process,...
MicroRNAs serve important roles in various diseases, particularly cancer. microRNA‑106a (miR‑106a) exhibits abnormal expression and oncogenic activity carcinogenesis. The clinical significance of the miR‑106a colorectal cancer is poorly understood. In present study, from tissues was quantified using reverse transcription‑quantitative polymerase chain reaction. overexpression or knockdown performed by transfection with microRNA mimic inhibitor human carcinoma HCT116 cells. promoted viability...