A5004405695- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Wound Healing and Treatments
- Cancer-related molecular mechanisms research
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- Knee injuries and reconstruction techniques
- Heterotopic Ossification and Related Conditions
- Bone fractures and treatments
- Bone and Joint Diseases
- Colorectal Cancer Treatments and Studies
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Transcranial Magnetic Stimulation Studies
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Agriculture and Biological Studies
- Spine and Intervertebral Disc Pathology
Shanghai Sixth People's Hospital
2015-2024
Shanghai Jiao Tong University
2015-2024
First Affiliated Hospital of Hebei Medical University
2020-2024
Hebei Medical University
2020-2024
Shanxi Agricultural University
2023-2024
Hunan Agricultural University
2024
Changzhou University
2022
Chinese University of Hong Kong, Shenzhen
2022
Dalian University of Technology
2000-2018
Forest Institute
2017
Human induced pluripotent stem cell-derived mesenchymal cells (hiPSC-MSCs) have emerged as a promising alternative for cell transplantation therapy. Exosomes derived from (MSC-Exos) can play important roles in repairing injured tissues. However, to date, no reports demonstrated the use of hiPSC-MSC-Exos cutaneous wound healing, and little is known regarding their underlying mechanisms tissue repair.hiPSC-MSC-Exos were injected subcutaneously around sites rat model efficacy was assessed by...
Osteoarthritis (OA) is the most common joint disease throughout world. Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells (SMSC-140s) may be effective in treating OA. We hypothesized that exosomes SMSC-140 (SMSC-140-Exos) would enhance proliferation and migration abilities of articular chondrocytes (ACs) without harming extracellular matrix (ECM) secretion.SMSCs were transfected with or miR-140-5p. SMSCs SMSC-140s (SMSC-Exos SMSC-140-Exos) isolated identified....
Chronic wounds have become an economic, social, and public health burden need advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of chronic because it contains abundance growth factors secreted by platelets. The exosomes derived from PRP (PRP-Exos) proven to encapsulate principal This study is the first show that these may exert function PRP. PRP-Exos can effectively induce proliferation migration endothelial cells fibroblasts improve angiogenesis...
‘Patient-specific’ induced pluripotent stem cells (iPSCs) are attractive because they can generate abundant without the risk of immune rejection for cell therapy. Studies have shown that iPSC-derived mesenchymal (iMSCs) possess powerful proliferation, differentiation, and therapeutic effects. Recently, most studies indicate exert their effect mainly through a paracrine mechanism other than transdifferentiation, exosomes emerged as an important factor to reprogram injured cells. The objective...
Abstract There is a need to find better strategies promote wound healing, especially of chronic wounds, which remain challenge. We found that synovium mesenchymal stem cells (SMSCs) have the ability strongly cell proliferation fibroblasts; however, they are ineffective at promoting angiogenesis. Using gene overexpression technology, we overexpressed microRNA-126-3p (miR-126-3p) and transferred angiogenic endothelial progenitor SMSCs, tested therapeutic strategy involving controlled-release...
An excess of glucocorticoids (GCs) is reported to be one the most common causes osteonecrosis femoral head (ONFH). In addition, GCs can induce bone cell apoptosis through modulating endoplasmic reticulum (ER) stress. Among three main signal pathways in ER stress, PERK (protein kinase RNA-like kinase)/CHOP (CCAAT-enhancer-binding protein homologous protein) pathway has been considered closely associated with apoptosis. Platelet-rich plasma (PRP) referred as a concentration growth factors and...
Diabetic nephropathy is one of the most serious complications in patients with diabetes. At present, there are no satisfactory treatments available for diabetic nephropathy. Stem cells currently main candidates development new nephropathy, as they may exert their therapeutic effects mainly through paracrine mechanisms. Exosomes derived from stem have been reported to play an important role kidney injury. In this article, we try investigate whether exosomes retrieved urine could itself...
Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance between catabolism anabolism extracellular matrix (ECM), is most common age-related degenerative joint disease worldwide. As sleep has been found to be beneficial for cartilage repair, circular RNAs (circRNAs) have demonstrated involved in pathogenesis OA, we performed RNA sequencing (RNA-seq), circRNA3503 was significantly increased after melatonin (MT)-induced cell sleep. Upregulation expression...
Diabetic wound healing has become a serious healthcare challenge. The high-glucose environment leads to persistent bacterial infection and mitochondrial dysfunction, resulting in chronic inflammation, abnormal vascular function, tissue necrosis. To solve these issues, we developed double-network hydrogel, constructed with pluronic F127 diacrylate (F127DA) hyaluronic acid methacrylate (HAMA), enhanced by SS31-loaded mesoporous polydopamine nanoparticles (MPDA NPs). As components, SS31,...
Diabetic wounds, one of the most enervating complications diabetes mellitus, affect millions people worldwide annually. Vascular insufficiency, caused by hyperglycemia, is primary causes and categories diabetic impaired wound healing. Recently, long noncoding RNA (LncRNA)-H19, which significantly decreased in may be crucial triggering angiogenesis, has attracted increasing interest. The possible relationship between decrease LncRNA-H19 impairment angiogenesis could involve...
Hydroxyapatite/chitosan composite hydrogels loaded with exosomes was fabricated for promoting wound surface re-epithelialization, angiogenesis, collagen maturity and diabetic chronic healing.
Stem cells in human urine have gained attention recent years; however, urine-derived stem (USCs) are far from being well elucidated. In this study, we compared the biological characteristics of USCs with adipose-derived (ASCs) and investigated whether could serve as a potential cell source for neural tissue engineering. were isolated voided modified culture medium. Through series experiments, examined growth rate, surface antigens, differentiation USCs, them ASCs. showed robust proliferation...
Osteonecrosis of the femoral head (ONFH) represents a debilitating complication following glucocorticoid (GC)-based therapy. Synovial-derived mesenchymal stem cells (SMSCs) can exert protective effect in animal model GC-induced ONFH by inducing cell proliferation and preventing apoptosis. Recent studies indicate transplanted therapeutic effects primarily via paracrine mechanism exosomes are an important factor that be directly used as agents for tissue engineering. Herein, we provided first...
Abstract Cartilage defects resulting from injury or degeneration are a common clinical problem, and due to its avascular nature, articular cartilage has poor self‐healing capacity. Three‐dimensional (3D) bioprinting attracted great attention in tissue engineering. Melatonin (MT), hormone mainly secreted at night, plays an important role repair. Small extracellular vesicles (sEV) considered ideal drug delivery vehicles MT‐sEV (sleep‐related sEV) have the potential ability promote...
Despite advancements in wound healing techniques and devices, new treatments are needed to improve therapeutic outcomes. This study aimed evaluate the potential use of a biomaterial engineered from human urine-derived stem cells (USCs) polycaprolactone/gelatin (PCL/GT) for healing.USCs were isolated healthy individuals. To fabricate PCL/GT composite meshes, twin-nozzle electrospinning used spin PCL gelatin solutions normal organic solvents. The morphologies hydrophilicity properties...
The discovery of induced pluripotent stem cells (iPSCs) rendered the reprogramming terminally differentiated to primary with pluripotency possible and provided potential for regeneration restoration cartilage defect. Chondrogenic differentiation iPSCs is crucial their application in tissue engineering. In this study we investigated effect 3D nanofibrous scaffolds on chondrogenesis articular defect restoration. Super-hydrophilic durable mechanic polycaprolactone (PCL)/gelatin were fabricated...