A5100388520- Food composition and properties
- Polysaccharides Composition and Applications
- Microbial Metabolites in Food Biotechnology
- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Dental Implant Techniques and Outcomes
- Advanced biosensing and bioanalysis techniques
- Phytase and its Applications
- Viral Infections and Immunology Research
- Catalysis for Biomass Conversion
- Catalytic Processes in Materials Science
- Inflammatory Bowel Disease
- Cancer-related molecular mechanisms research
- Hepatitis B Virus Studies
- Proteins in Food Systems
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Childhood Cancer Survivors' Quality of Life
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
- Catalysts for Methane Reforming
Tianjin Medical University General Hospital
2015-2025
Affiliated Hospital of Southwest Medical University
2023-2025
Guangxi Medical University
2020-2024
University of Malaya
2019-2024
Sun Yat-sen University
2023-2024
Shenzhen Institute of Information Technology
2024
Weatherford College
2024
Community Health Center
2024
Qingdao University
2024
Anhui Medical University
2024
Abstract Hepatocellular carcinoma (HCC) generally possesses a high resistance to chemotherapy. Given that autophagy is an important factor promoting tumor chemoresistance and HCC express low level of miR-26, we aim investigate the functional role miR-26 in autophagy-mediated HCC. We found chemotherapeutic drug doxorubicin (Dox) induced but decreased miR-26a/b cells. Activating using rapamycin can directly downregulate In turn, restoring expression inhibited by Dox promoted apoptosis Further...
Starch is the most abundant organic compound in nature, second only to cellulose. However, conserved structure of native starches limits their properties and applications. Therefore, it often necessary modify them obtain specific properties. As a common green safe physical modification method, pre-gelatinization can improve cold water solubility swelling power starch. The typical preparation methods pre-gelatinized starch include spray drying, extrusion, drum drying. Spray-dried still had...
The matrix protein VP40 plays a critical role in Ebola virus assembly and budding, process that utilizes specialized membrane domains known as lipid rafts. Previous studies with purified suggest for oligomerization of this process. Here, we demonstrate oligomers rafts mammalian cells, virus-like particles, the authentic virus. By mutagenesis, identify several C-terminal sequences regulate at plasma membrane, association detergent-resistant membranes, vesicular release VP40, directly linking...
The Co(III)-catalyzed redox-neutral annulation of benzamides and acrylamides with vinylene carbonate for the synthesis isoquinolinones pyridinones has been developed. This protocol employing inexpensive Co(III) as catalyst tolerated diverse functional groups substitution patterns, affording target products good to excellent yields. synthetic utility this transformation was demonstrated by a three-step gusanlung D, 8-oxopseudopalmatine, oxopalmatine.
Summary Wheat flour was ground in an ultrafine pulveriser to obtain different levels of damaged starch ( DS ). The effect content on physicochemical properties and quality attributes Chinese noodles northern‐style steamed bread were investigated. Results showed that the degree damage raised from 6.54% 12.06% as grinding intensity increased 0 130 Hz P < 0.05). falling number, sedimentation value, pastes' viscosity, dough proofing stability negatively, while water absorption, pastes thermal...
Abstract Visceral adiposity is strongly associated with metabolic disease risk, whereas subcutaneous comparatively benign. However, their relative physiological importance in energy homeostasis remains unclear. Here, we show that after 24-h fasting, the adipose tissue of mice acquires key properties visceral fat. During this fast-induced ‘visceralization’, upregulation miR-149-3p directly targets PR domain containing 16 (PRDM16), a coregulatory protein required for ‘browning’ white In...
The mechanisms underlying human cytomegalovirus (HCMV) latency remain incompletely understood. Here, we showed that a HCMV-encoded miRNA, miR-UL148D, robustly accumulates during late stages of experimental latent HCMV infection in host cells and promotes by modulating the immediate early response gene 5 (IER5)-cell division cycle 25B (CDC25B) axis cells. miR-UL148D inhibited IER5 expression directly targeting three-prime untranslated region(3'UTR) mRNA thus rescued CDC25B establishment viral...
The leukemia affects not only the quality of life (QOL) patients with disease but also that their family caregivers (FCs). research studies on QOL FCs for are limited. This study aimed to evaluate in Heilongjiang province, China.A cross-sectional questionnaire survey was undertaken 309 recruited from three hospitals province. participants assessed using Chinese version WHOQOL-BREF. Multivariate regression models were established determine predictors FCs, including socio-economic...
Abstract Background Klotho has both anticancer and hormone‐like functions. But the research on cancer is mainly based animal experiments small‐scale clinical research, thus we explored association between serum mortality National Health Nutrition Survey (NHANES). Methods Participants were employed from NHANES 2007–2016, excluding pregnant, chronic renal insufficiency, incomplete data of questionnaire level. The with was analyzed by weighted Logistic regression, Cox regression competitive...
The demand for a clean production process of adipic acid (AA) can be achieved by developing synthetic route using H2O2 as the oxidant. In this paper, green with recyclable catalyst system consisting H2WO4, H2SO4 and H3PO4 was developed AA via catalytic oxidation cyclohexene. A continuous-flow reactor set up optimization reaction parameters industrial operation process. mixture acidic promoter displays significant improvement in activity stability H2O2. could recovered reused 20 times, no...
Excessive abdominal fat deposition is an issue with general concern in broiler production, especially for Chinese native chicken breeds. A high-fat diet (HFD) can induce body weight gained and excessive deposition, genes pathways participate metabolism adipogenesis would be influenced by HFD. In order to reveal the main involved we used HFD normal (ND) feed a breed, respectively. Results showed that increase adipocyte hypertrophy. Additionally, RNA-sequencing identify differentially...
Abstract This case series compared clinical variables and various combinations of immunotherapy received with outcomes patients severe acute necrotizing encephalopathy (ANE). We performed a retrospective review variables, received, (based on the modified Rankin Scale) in Malaysia between February 2019 January 2020. Twenty‐seven children (12 male), aged 7 months to 14 years (mean 4 years) at diagnosis were included. Of these, 23 had an ANE severity score 5 9 out (high risk). Eleven...
Patients with inflammatory bowel disease (IBD) are at risk of developing malnutrition, severe dystrophic muscle weakness, and atrophy. We present a case 33-year-old male patient who exhibited concurrent atrophy, diarrhea, mucopurulent bloody stools. Notably, the reported that his household or family members experienced similar symptoms without any apparent neurological psychiatric manifestations. The patient’s intestinal were most consistent ulcerative colitis, while weakness originated from...
Plasma phosphorylated tau at threonine 217 (p-tau217) measured with an ultrasensitive immunoassay method has been demonstrated to be optimal biomarker for Alzheimer's disease (AD). The aim of this study was establish the reference interval plasma p-tau217 in Chinese individuals and evaluate its diagnostic value symptomatic AD. We recruited 150 cognitively unimpaired (CU) individuals, 60 patients AD dementia, 30 mild cognitive impairment (MCI) due AD, 40 frontotemporal lobar degeneration...