A5051656216- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Medical Imaging and Analysis
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Shoulder Injury and Treatment
- Spine and Intervertebral Disc Pathology
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Dental Implant Techniques and Outcomes
- Spinal Fractures and Fixation Techniques
- Advanced X-ray and CT Imaging
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
- Shoulder and Clavicle Injuries
- Immunotherapy and Immune Responses
- Soft Robotics and Applications
- Asphalt Pavement Performance Evaluation
- Virus-based gene therapy research
- Dental Radiography and Imaging
- Prosthetics and Rehabilitation Robotics
- Assisted Reproductive Technology and Twin Pregnancy
- Bone fractures and treatments
- Hip disorders and treatments
KU Leuven
2015-2024
Flanders Make (Belgium)
2024
Universitair Ziekenhuis Leuven
2008
Hasselt University
2008
Specialty Materials (United States)
1991-1995
Howard Hughes Medical Institute
1987-1990
University of Michigan
1990
University of Chicago
1988
University of California, Los Angeles
1984-1987
Columbia University
1986
To evaluate image quality by examining segmentation accuracy and assess radiation dose for cone beam CT (CBCT) scanners.A skull phantom, scanned a laser scanner, contrast phantom were used to accuracy. The consisted of polymethyl methacrylate (PMMA) cylinder with cylindrical inserts air, bone PMMA. phantoms on the (1) Accuitomo 3D, (2) MercuRay, (3) NewTom 3G, (4) i-CAT (5) Sensation 16. structures segmented an optimal threshold. Thicknesses mandible diameter cylinders in measured across...
Previous work (6-10) has shown that allelic exclusion of Ig gene expression is controlled by functionally rearranged mu and kappa genes. This report deals with the comparison membrane (micron) secreted (microsecond) in promoting such feedback inhibition. Splenic B cell hybridomas were analyzed from transgenic mice harboring a alone or combination either an intact truncated version gene. The capable producing both forms protein, while can only encode form. role microsecond was also tested...
The ability to engraft human PBMC or fetal tissue immune cells in the severe combined immunodeficient (SCID) mouse has created a need for characterization of these systems and their application disease models. We demonstrate that SCID mice reconstituted with support growth differentiation restricted set B cells. Human IgG levels 1-2 mg/ml (10-20% normal serum levels) were routinely achieved spite half life only 12 d. Ig peaked around 50 d production was maintained greater than 100 85% though...
In order to define abnormalities of humoral immunity which determine susceptibility respiratory tract infections in IgA-deficient adults, serum IgG subclass concentrations, and concentrations pneumococcal antibodies Haemophilus influenzae type B (Hib) sera from adults with without were compared. Infection was not related the degree IgA deficiency, but deficiency IgG4 and, a lesser extent, IgG2, as well low basal polysaccharide antibodies. The combination IgG2 and/or non-protective...
The study evaluates the accuracy of predicting intracochlear pressure during bone conduction stimulation using promontory velocity and ear canal pressure, as less invasive alternatives to pressure. Stimulating with a percutaneous device implanted in six human cadaveric ears, measurements were taken across various intensities, frequencies, positions. Results indicate that linearly correlates (
We determined that mouse lymphoid cell lines can be transfected at high efficiencies (10-70%) by a polyoma virus shuttle vector. With this vector, we obtained expression of cloned alpha heavy chain gene into representative all stages in B-lymphocyte development, T-cell lymphoma line, and 3T3 fibroblasts. Heavy light chain-producing myeloma cells occurred levels comparable to those IgA-secreting cells. chains produced were associated with membrane-bound IgA. While T-lymphoma fibroblasts...
An in vitro system for the study of B-lymphocyte differentiation from precursor elements has been established. Two separate sets culture conditions are utilized to control growth versus differentiation. The first, modeled after bone marrow Dexter and colleagues [Dexter, T. M. & Testa, N. G. (1976) Methods Cell Biology, ed. Prescott, D. (Academic, New York), Vol. 14, pp. 387-395], allows replication whereas second set is permissive more mature members lineage. shift one other us follow...
Abstract Long-term lymphoid bone marrow cultures (LBMC) produce B lymphocytes and their precursors for several months in vitro. To assess differentiative potential determine capacity to function as immune effectors, cells from the were transplanted into mice with severe combined deficiency disease (SCID). SCID are deficient T serum immunoglobulin (Ig) negative, but grafts of normal can expand differentiate them, thereby restoring immunocompetence. The results these studies indicate that LBMC...
Long-term cultures of murine fetal liver have been successfully established using a modification our in vitro bone marrow culture system (14, 15). Fetal cells from midgestation BALB/c embryos were plated onto BAB-14 stromal cell-adherent layers. After 3-5 wk period, cell growth began to increase and these expanded number on fresh feeder The cultured lymphoid morphology, 5-20% cytoplasmic Ig-positive, but less than 1% surface Ig-positive. Southern blot analysis the cells, as well...
Two hybridoma cell lines were established with B cells derived from neonatal BALB/c spleen cells. The anti-dinitrophenyl (DNP) antibodies these characterized respect to their isotype, affinity, and isoelectric point. Antiidiotypic reagents prepared that permit an analysis of the representation sharing idiotype two hybridomas in developing mature pool mice (Igha) other murine strains. One antibodies, TF2-36, was found be indistinguishable 14% anti-DNP monoclonal fragment culture 1-4-d-old...
The initial stability of cementless total hip arthroplasty (THA) implants is obtained by an interference fit that allows osseointegration for a long term secondary the implant. Yet, finding insertion endpoint corresponds to appropriate currently often based on number subjective experiences orthopedic surgeon, which can be challenging. In order assist surgeons in their pursuit find this optimal stability, study aims determine whether analysis sound results from implant hammer blows used...
Pedicle drilling is a complex and critical spinal surgery task. Detecting breach or penetration of the surgical tool to cortical wall during pilot-hole essential avoid damage vital anatomical structures adjacent pedicle, such as cord, blood vessels, nerves. Currently, guidance pedicle done using image-guided methods that are radiation intensive limited preoperative information. This work proposes new radiation-free detection algorithm leveraging non-visual sensor setup in combination with...
Total knee arthroplasty requires accurate preparation of the bone surfaces to maximize implant contact area in cementless surgery and obtain proper joint kinematics ligament balancing. Robots can make cuts with necessary high precision. The purpose this article is threefold: propose an alternative method for intraoperative registration using intramedullary rod force control hybrid force-velocity scheme; demonstrate that accuracy surface flatness machined by a robot are better than...
Total knee arthroplasty requires accurate preparation of the bone surfaces to maximize implant contact area in cementless surgery and obtain proper joint kinematics ligament balancing. Robots can make cuts with necessary high precision. The purpose this article is threefold: propose an alternative method for intraoperative registration using in-tramedullary rod force control hybrid force-velocity scheme; demonstrate that accuracy surface flatness machined by a robot are better than...