A5100622533- Wnt/β-catenin signaling in development and cancer
- Neuroscience and Neuropharmacology Research
- Cancer-related gene regulation
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Cancer Cells and Metastasis
- Nuclear Receptors and Signaling
- Parkinson's Disease Mechanisms and Treatments
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Amino Acid Enzymes and Metabolism
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Kruppel-like factors research
- Epigenetics and DNA Methylation
- Nutrition, Genetics, and Disease
- Neurogenesis and neuroplasticity mechanisms
- Animal Genetics and Reproduction
- Cancer Risks and Factors
- Plant Virus Research Studies
- Diverse Approaches in Healthcare and Education Studies
- Health and Wellbeing Research
Florida Agricultural and Mechanical University
2016-2025
Gyeongsang National University
2024
Asan Medical Center
2019-2023
National Cancer Center
2012-2023
Gyeongsangnam-do Agricultural Research and Extension Services
2014-2023
University of Ulsan
2023
Ulsan College
2023
Kyungpook National University
2022
Dankook University
2021
Seoul National University Hospital
2015-2019
The recurrence score based on the 21-gene breast-cancer assay has been clinically useful in predicting a chemotherapy benefit hormone-receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative, axillary lymph-node-negative breast cancer. In women with positive lymph-node disease, role of respect to adjuvant is unclear.In prospective trial, we randomly assigned HER2-negative cancer, one three lymph nodes, and 25 or lower (scores range from 0 100, higher scores indicating...
Although manganese (Mn) is an essential trace element for human development and growth, chronic exposure to excessive Mn levels can result in psychiatric motor disturbances, referred as manganism. However, there are no known mechanism(s) efflux of excess from mammalian cells. Here, we test the hypothesis that cytoplasmic iron (Fe) exporter ferroportin (Fpn) may also function a attenuate toxicity. Using inducible embryonic kidney (HEK293T) cell model, examined influence Fpn expression on...
Chronic exposure to manganese (Mn) can cause manganism, a neurodegenerative disorder similar Parkinson's disease. The toxicity of Mn includes impairment astrocytic glutamate transporters. 17beta-Estradiol (E2) has been shown be neuroprotective in various diseases including disease and Alzheimer's disease, some selective estrogen receptor modulators, tamoxifen (TX), also possess properties. We have tested our hypothesis that E2 TX reverse Mn-induced transporter astrocytes. results established...
We examined the factors affecting clinical nurses’ turnover intention and constructed a structural equation model based on Culture–Work–Health Model. This cross-sectional study utilized self-administered questionnaires. Registered nurses ( N = 252) from four tertiary hospitals participated. Factors included organizational culture, job stress, fatigue (explanatory power 56.7%), showed acceptable goodness of fit. In final model, stress had direct effects culture indirect effects. The also...
Chronic manganese (Mn) exposure can lead to manganism, a neurological disorder sharing common symptoms with Parkinson's disease (PD). Studies have shown that Mn increase the expression and activity of leucine-rich repeat kinase 2 (LRRK2), leading inflammation toxicity in microglia. LRRK2 G2019S mutation also elevates activity. Thus, we tested if Mn-increased microglial is responsible for Mn-induced toxicity, exacerbated by mutation, using WT knock-in mice, BV2 (30 mg/kg, nostril...
Impairment of astrocytic glutamate transporter (GLT-1; EAAT2) function is associated with multiple neurodegenerative diseases, including Parkinson's disease (PD) and manganism, the latter being induced by chronic exposure to high levels manganese (Mn). Mn decreases EAAT2 promoter activity mRNA protein levels, but molecular mechanism Mn-induced repression at transcriptional level has yet be elucidated. We reveal that transcription factor Yin Yang 1 (YY1) critical in repressing mediates...
Tamoxifen (TX), a selective estrogen receptor modulator, exerts antagonistic effects on breast tissue and is used to treat cancer. Recent evidence also suggests that it may act as an agonist in brain tissue. We reported previously TX enhanced the expression function of glutamate transporter 1 (GLT-1) rat astrocytes, effect was mediated by TGF-α. To gain further insight into mechanisms mediate TX-induced up-regulation GLT-1 (EAAT2 humans), we investigated its at transcriptional level....
Raloxifene (RX), a selective estrogen receptor modulator (SERM), exerts neuroprotection in multiple clinical and experimental settings. Astrocytic glutamate transporters GLT-1 (EAAT2) GLAST (EAAT1) are the main central nervous system, taking up most of excess from synaptic cleft to prevent excitotoxic neuronal death. Since drugs targeting astrocytic enhance their expression function represent potential therapeutics for neurodegenerative disorders associated with excitotoxicity, we tested if...
Long-term exposure to elevated levels of manganese (Mn) causes manganism, a neurodegenerative disorder with Parkinson's disease (PD)-like symptoms. Increasing evidence suggests that leucine-rich repeat kinase 2 (LRRK2), which is highly expressed in microglia and macrophages, contributes the inflammation neurotoxicity seen autosomal dominant sporadic PD. As gene-environment interactions have emerged as important modulators PD-associated toxicity, LRRK2 may also mediate Mn-induced...
Glutamine (Gln) plays an important role in brain energy metabolism and as a precursor for the synthesis of neurotransmitter glutamate GABA. Previous studies have shown that astrocytic Gln transport is impaired following manganese (Mn) exposure. The present were performed to identify routes respective transporters contributing impairment. Rat neonatal cortical primary astrocytes treated with Mn displayed significant decrease uptake mediated by principle transporting systems, N ASC. Moreover,...
Manganese (Mn) is an essential element that required in trace amount for normal growth, development as well maintenance of proper function and regulation numerous cellular biochemical reactions.Yet, excessive Mn brain accumulation upon chronic exposure to occupational or environmental sources this metal may lead a neurodegenerative disorder known manganism, which shares similar symptoms with idiopathic Parkinson's disease (PD).In recent years, has gained public health interest two primary...