A5102026285- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Nanoplatforms for cancer theranostics
- Chemical Synthesis and Analysis
- Antimicrobial Peptides and Activities
- Advanced Biosensing Techniques and Applications
- Chemical Synthesis and Reactions
- Cancer, Lipids, and Metabolism
- Glycosylation and Glycoproteins Research
- Corneal Surgery and Treatments
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Advanced Nanomaterials in Catalysis
- Cytokine Signaling Pathways and Interactions
Sichuan University
2019-2025
Hubei University of Arts and Science
2015-2025
Stomatological Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Nagasaki University
2025
Soochow University
2025
Wuhan University of Science and Technology
2024
Guangxi Medical University
2009-2024
Guangdong Polytechnic Normal University
2024
Qilu Hospital of Shandong University
2021-2023
Choroidal neovascularization (CNV) is a common pathological feature of various eye diseases and an important cause visual impairment in middle-aged elderly patients. In previous studies, tetrahedral framework nucleic acids (tFNAs) showed good carrier performance. this experiment, we developed microRNA-155-equipped tFNAs (T-155) explored its biological effects on CNV. Based the results in-vitro experiments, T-155 could regulate macrophages into antiangiogenic M1 type. Then, injected vitreous...
Abstract Angiogenesis is crucial for tissue engineering, wound healing, and regenerative medicine. Nanomaterials constructed based on specific goals can be employed to activate endogenous growth factor‐related signaling. In this study, the conventional single‐stranded DNA self‐assembly into tetrahedral framework nucleic acids (tFNAs), Apt02 acid aptamer dimethyloxallyl glycine (DMOG) small molecule are integrated a complex via template‐based click chemistry reaction toehold‐mediated strand...
Antimicrobial peptides (AMPs) have been an attractive alternative to traditional antibiotics. However, considerable efforts are needed further enhance their antimicrobial effects and stability against bacterial degradation. Tetrahedral framework nucleic acids (tFNAs), a new class of three-dimensional nanostructures, utilized as delivery vehicle. In this study, tFNAs were combined for the first time with peptide GL13K, resultant complexes Escherichia coli (sensitive GL13K) Porphyromonas...
Long-term potentiation (LTP) is the key cellular mechanism for physiological learning and pathological chronic pain. In anterior cingulate cortex (ACC), postsynaptic recruitment or modification of AMPA receptor (AMPAR) GluA1 contribute to expression LTP. Here we report that pyramidal cells in deep layers ACC send direct descending projecting terminals dorsal horn spinal cord (lamina I-III). After peripheral nerve injury, these projection are activated, excitatory responses neurons were...
Currently available strategies show limited effects in preventing morbidity and disability from chronic diabetic wounds. Ideal vascularization is indispensable for better restoration prognosis of This study aims to investigate the role tetrahedral framework nucleic acids (tFNAs) process angiogenesis during wound healing underlying mechanism. The vitro results showed that tFNAs treatment enhanced formation a vessel-like structure was inhibited by advanced glycation end products (AGEs)....
While the skin is considered first line of defense in human body, there are some vulnerabilities that render it susceptible to certain threats, which an issue recognized by both patients and doctors. Cutaneous wound healing a series complex processes involve many types cells, such as fibroblasts keratinocytes. This study showed tetrahedral framework nucleic acids (tFNAs), type self-assembled nucleic-acid material, have ability promote keratinocyte(HaCaT cell line) fibroblast(HSF...
siRNA is found to effectively knock down the target gene in cells, which considered a promising strategy for therapy. However, application of limited due its low efficiency cellular uptake. Tetrahedral framework nucleic acids (tFNAs) are synthesized by four single-stranded DNAs and show multiple biological functions recent studies, especially suitable drug delivery. More than 60% malignant melanomas associated with Braf mutation, an attractive therapeutic RNA interference. In this study, we...
Abstract Sepsis has affected millions of people worldwide with high mortality rate and lack effective strategies. Previous studies have reported that quercetin (Que) can attenuate lipopolysaccharide (LPS)‐Induced sepsis. However, for poor water solubility, low bioavailability, instability, the application Que is limited. Hence, a nano‐system constructed to deliver based on tetrahedral framework nucleic acid (tFNA), namely tFNA‐Que. For anti‐inflammatory, anti‐oxidant, delivery performance...
Retinal ischemia-reperfusion (I/R) injuries are involved in the universal pathological processes of many ophthalmic diseases, including glaucoma, diabetic retinopathy, and retinal arterial occlusion.
Acute myocardial infarction, which can be extremely difficult to treat, is the worst deadly disease around world. Reperfusion expedient reverse ischemia. However, during reperfusion, reactive oxygen species (ROS) produced by ischemia-reperfusion injury (MIRI) and further cell apoptosis are most serious challenges cardiomyocytes. Therefore, searching for reagents that simultaneously reduce oxidative damage MIRI-induced pivotal strategy rescue injured Nevertheless, current cardioprotective...
Abstract Glaucoma is the world's leading irreversible cause of blindness. It characterized by progressive retinal ganglion cells (RGCs) loss and axon damage, there no effective prevention or treatment so far. In this study, tetrahedral frame nucleic acids (tFNAs) with various biological functions are selected as carrier, microRNA‐22‐3p (miR‐22) modified attaching them onto tFNAs to synthesize a novel DNA nanocomplex (tFNAs‐miR22). Relevant results show that can efficiently transfer miR‐22...
Parkinson's disease (PD) is the most common chronic neurodegenerative and characterized by motor dysfunctions. Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of neurotoxicity that causes PD. As an inhibitor LRRK2 activity, vitamin B12 (VB12) promising therapeutic option for PD shown to restore autophagy models. However, dependence on transporters extremely low brain tissue utilization VB12 limit its effects. Based this, VB12-loaded tetrahedral framework...
An environmentally friendly and scalable protocol was developed for direct amidation of unactivated esters under transition-metal-free, solvent-free chromatography-free conditions.
Skin is the first barrier against external threats, and skin immune dysfunction leads to multiple diseases. Psoriasis an inflammatory, chronic, common, immune-related disease that affects more than 125 million people worldwide. RNA interference (RNAi) therapy superior traditional therapies, but rapid degradation poor cell uptake are greatest obstacles its clinical transformation. The transdermal delivery of siRNA controllable assembly/disassembly nanodrug systems can maximize therapeutic...
The heterogeneities of colorectal cancer (CRC) lead to staging inadequately patients' prognosis. Here, we performed a prognostic analysis based on the tumor mutational profile and explored characteristics high-risk tumors. We sequenced 338 carcinomas as training dataset, constructed novel five-gene (SMAD4, MUC16, COL6A3, FLG LRP1B) signature, validated it in an independent dataset from Cancer Genome Atlas (TCGA). Kaplan-Meier Cox regression analyses confirmed that signature is predictor...
Parkinson's disease (PD) is a neurodegenerative characterized by series of progressive motor disorders. PD caused dysfunction basal ganglia, decrease dopaminergic neurons in substantia nigra, and abnormal accumulation Lewy bodies neurites. Antiparkinsonian agents, which are currently used for treatment PD, exhibit unsatisfactory effects on control. In recent years, tetrahedral framework nucleic acids (TFNAs) have been considered as multifunctional nanomaterials, their scope application has...
The repair of damaged endothelium is crucial for vascular homeostasis maintenance, which comprises the recovery early stage impaired endothelial cells and migration surrounding unimpaired cells. MicroRNAs (miRNAs) play an indispensable role in balancing gene expression organisms. For tissues, miR-126 one most important regulators might have substantial application potential maintaining homeostasis. In this study, a type sticky-end-modified tetrahedral framework nucleic acids (tFNAs-SE) was...
Cuproptosis, the newly identified form of regulatory cell death (RCD), results from mitochondrial proteotoxic stress mediated by copper and FDX1. Little is known about significances cuproptosis in oncogenesis. Here we determined clinical implications clear renal carcinoma (ccRCC). Based on correlation survival analyses cuproptosis-correlated genes TCGA ccRCC cohort, constructed a cuproptosis-associated 13 gene signature (CuAGS-13) score system. In both training two validation cohorts, when...
Liver fibrosis, an early stage of cirrhosis, with large number patients and seriously endangering health, has no viable treatment available currently. In this study, we choose tetrahedral framework nucleic acid nanoparticles as carriers to deliver the polyphenolic monomer chlorogenic injured liver for first time. This delivery system enhanced bioavailability stability acid, laying foundation its antifibrotic antioxidant effects. Our findings show that approach can reduce fibrosis by...
Peptide-based therapeutics are natural candidates to desirable wound healing. However, enzymatic surroundings largely limit its stability and bioavailability. Here, we developed a tetrahedral framework nucleic acids(tFNA)-based peptide delivery system, that is, p@tFNAs, address deficiencies of healing intracellular in diabetic healing.AGEs (advanced glycation end products) were used treat endothelial cell simulate injury microenvironment. The effects related mechanisms p@tFNAs on...