A5102004791- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Bacteriophages and microbial interactions
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Iron-based superconductors research
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Advanced Nanomaterials in Catalysis
- Bone and Joint Diseases
- Rare-earth and actinide compounds
- Bone health and treatments
- Biosensors and Analytical Detection
- Antibiotic Resistance in Bacteria
- Gold and Silver Nanoparticles Synthesis and Applications
- Nanocomposite Films for Food Packaging
- Biochemical and Structural Characterization
- Facial Trauma and Fracture Management
- Dendrimers and Hyperbranched Polymers
- Nanocluster Synthesis and Applications
- Medicinal Plants and Neuroprotection
- Pharmaceutical and Antibiotic Environmental Impacts
- Antimicrobial Resistance in Staphylococcus
- Bone Tissue Engineering Materials
Southeast University
2024
Sichuan University
2019-2023
Ningxia Medical University General Hospital
2023
Ningxia Medical University
2015-2023
State Key Laboratory of Oral Diseases
2019-2022
Chengdu University
2020-2021
Stomatology Hospital
2020-2021
Nantong University
2021
Shenzhen University Health Science Center
2020
Shanghai Normal University
2020
Antimicrobial peptides (AMPs) have been an attractive alternative to traditional antibiotics. However, considerable efforts are needed further enhance their antimicrobial effects and stability against bacterial degradation. Tetrahedral framework nucleic acids (tFNAs), a new class of three-dimensional nanostructures, utilized as delivery vehicle. In this study, tFNAs were combined for the first time with peptide GL13K, resultant complexes Escherichia coli (sensitive GL13K) Porphyromonas...
Erythromycin is a commonly used broad-spectrum antibiotic, but resistance to this antibiotic makes its use less effective. Considerable efforts, beside finding alternatives, are needed enhance antimicrobial effect and stability against bacteria. Tetrahedral framework nucleic acids (tFNAs), novel delivery vehicle with three-dimensional nanostructure, have been studied as carrying platform of antineoplastic drugs. In study, the tFNAs in delivering erythromycin into
Bisphosphonates are often used to treat osteoporosis, malignant bone metastases, and hypercalcemia. However, it can cause serious adverse reactions, bisphosphonate-related osteonecrosis of the jaw (BRONJ), which seriously affects quality life patients. At present, treatment BRONJ is still difficult reach an agreement, there no effective treatment. Therefore, very important find treatments. Many studies have shown that occurrence may be due unbalanced turnover, anti-angiogenesis, bacterial...
The significant clinical feature of bisphosphonate-related osteonecrosis the jaw (BRONJ) is exposure necrotic jaw. Other manifestations include pain, swelling, abscess, and skin fistula, which seriously affect patients' life, there no radical cure. Thus, new methods need to be found prevent occurrence BRONJ. Here, a novel nanoparticle, tFNA-KLT, was successfully synthesized by us, in nanoparticle tetrahedral framework nucleic acid (tFNA) used for carrying angiogenic peptide, KLT, then...
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated effects of Hcy on fatty acid‐binding protein 4 (FABP4), and tested our hypothesis that Hcy‐induced atherosclerosis mediated by increased FABP4 expression decreased methylation. The DNA methylation was assessed in aorta ApoE −/− mice fed high‐methionine diet 20 weeks. Over‐expression enhanced accumulation total cholesterol ester foam cells. up‐regulation...
The overuse of antibiotics has led to the emergence multidrug-resistant pathogens. There is an urgent need develop alternative therapeutic strategies reduce mortality and morbidity related drug-resistant bacterial infections. Self-synthesized tetrahedral framework nucleic acids (tFNAs) are used as drug loading platform deliver ampicillin combat methicillin-resistant Staphylococcus aureus (MRSA) infection. results average dimension, zeta potential, transmission electron microscopy,...
Abstract Objectives Due to the instability of microRNAs, applications microRNA are currently limited. Thus, we utilized tetrahedral framework nucleic acids and a targeted microRNAs form stable nanocomposite explore whether this can promote apoptosis tumour cells. Materials methods In our study, survivin gene, which is expressed only in cells embryonic cells, was selected as target gene; miRNA‐214‐3p, reduce expression survivin, modified onto acid, thereby producing reduction upon...
In a search for solution to large-area soft and hard tissue defects, whether or not regeneration tissue-substitutes transplantation is used, the problems with angiogenesis need be solved urgently. Thus, new efficient proangiogenic approach needed. Nanoengineering systems have been considered one of most promising approaches. this study, we modify tetrahedral framework nucleic acid (tFNA) first time two different angiogenic DNA aptamers form aptamer–tFNA nanostructures, tFNA–Apt02...
Antibiotic multiresistance (AMR) has emerged as a major threat to human health millions of people die from AMR-related problems every year. As been witnessed during the global COVID-19 pandemic, significantly increased demand for antibiotics aggravated issue AMR. Therefore, there is an urgent need find ways alleviate it. Tetrahedral framework nucleic acids (tFNAs) are novel nanomaterials that often used drug delivery platforms because their structural diversity. This study formed...
DNA methyltransferase 1 (DNMT1) and miRNAs are both important regulators of gene expression that have been implicated in the pathogenesis atherosclerosis. This study was designed to elucidate potential interaction between DNMT1 context hyperhomocysteinemia (HHcy)-related In aorta ApoE-/- mice fed a high methionine diet, increased miR-148a/152, with decreased mRNA protein levels, detected. Similar changes were observed cultured foam cells stimulated homocysteine. When miR-148a/152...
Conventional antiangiogenetic inhibitors suffered from poor delivery problems that result in unsatisfactory antitumor treatment efficacy. Although the liposomes or nanomaterial-based systems can improve therapeutic efficacy of antiangiogenic molecules, assembly process is far too complex. Herein, a nanomaterial new nanodrug could work without help carrier and be easily synthesized needed. Au nanoclusters (AuNCs) are kind ideal nanostructures spontaneously enter into cell by relatively easy...
Abstract Objectives Anti‐microbial peptides (AMPs) have been comprehensively investigated as a novel alternative to traditional antibiotics against microorganisms. Meanwhile, Tetrahedral DNA nanostructures (TDNs) gained attention in the field of biomedicine for their premium biological effects and transportation efficiency delivery vehicles. Hence, this study, TDN/Histatin 5 (His‐5) was synthesized transport anti‐fungal effect were measured evaluate promotion His‐5 modified by TDNs....
Senile osteoporotic fracture has aroused increasing attention due to high morbidity and mortality. However, date, there is no effective therapeutic approach available. osteoporosis characterized by impaired osteogenesis angiogenesis, repair could also be promoted enhancing angiogenesis. Tetrahedral framework nucleic acids (tFNAs) are a multifunctional nanomaterial that have recently been extensively used in biomedical fields, which enhance angiogenesis vitro. Therefore, we applied tFNAs...
Urban vegetation can deposit dust to reduce pollution, and retention capacity of has become an important indicator for urban ecological construction. We selected five representative in Shanghai explore the regularity deposition on leaves. Due influence leaf area surface characteristics, amount was significantly different each vegetation; Vegetation shows under pollution intensity, before this reaches its limit, it will increase with content environment; Furthermore, water leaves factor...
Utilization of sublethal concentrations cinnamon essential oil (CEO) for food preservation has been proposed. However, exposure to stressful, growth conditions may induce bacterial tolerance homologous or heterologous stressing agents. Hence, the ability CEO stimulate stress response was evaluated in current work. Staphylococcus aureus exposed 1/4 and 1/2 minimum inhibitory concentration (MIC, 500 μL/L) 18 h. It found that overnight habituation failed direct cross-tolerance lactic acid (pH...
Background: Adequate peri-implant bone mass and quality are essential factors to ensure the initial stability of implant success operation. In clinical settings, lack often restricts this study, we fabricated a smart porous scaffold with shape memory function investigated whether it could promote osteogenesis under periosteum. Methods: A polymer (SMP) was its function, mechanical properties, degradation rate were tested in vitro. Moreover, implanted mandible rabbits evaluate efficacy...
The challenges associated with muscle degenerative diseases and volumetric loss (VML) emphasizes the prospects of tissue regeneration.