A5103161299- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Urinary and Genital Oncology Studies
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Pelvic floor disorders treatments
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Pelvic and Acetabular Injuries
- Sexual function and dysfunction studies
- Ureteral procedures and complications
- Reconstructive Surgery and Microvascular Techniques
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Birth, Development, and Health
- Urinary Tract Infections Management
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Pediatric Urology and Nephrology Studies
- Peroxisome Proliferator-Activated Receptors
Ningxia Medical University
2013-2025
Peking University
2016-2025
Beijing Jishuitan Hospital
2016-2025
Capital Medical University
2010-2025
Guangzhou University of Chinese Medicine
2021
Weatherford College
2021
Fujian Medical University
2007-2020
First People's Hospital of Chongqing
2020
First Affiliated Hospital of Fujian Medical University
2007-2020
Peking University First Hospital
2003-2005
Rosuvastatin (RVS) is an excellent drug with anti-inflammatory and lipid-lowering properties in the academic medical fields. However, this faces a series of challenges when used to treat atherosclerosis caused by hyperhomocysteinemia (HHcy), including high oral dosage, poor targeting, long-term toxic side effects. In study, we applied nanotechnology construct biomimetic nano-delivery system, macrophage membrane (Møm)-coated RVS-loaded Prussian blue (PB) nanoparticles (MPR NPs), for improving...
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated effects of Hcy on fatty acid‐binding protein 4 (FABP4), and tested our hypothesis that Hcy‐induced atherosclerosis mediated by increased FABP4 expression decreased methylation. The DNA methylation was assessed in aorta ApoE −/− mice fed high‐methionine diet 20 weeks. Over‐expression enhanced accumulation total cholesterol ester foam cells. up‐regulation...
Abstract It is well‐established that homocysteine (Hcy) an independent risk factor for atherosclerosis. Hcy can promote vascular smooth muscle cell (VSMC) proliferation, it plays a key role in neointimal formation and thus contribute to arteriosclerosis. However, the molecular mechanism on VSMCs proliferation underlying atherosclerosis not well elucidated. Mitofusin‐2 (MFN2) important transmembrane GTPase mitochondrial outer membrane block cells G0/G1 stage of cycle. To investigate...
Hyperhomocysteinemia (HHcy), which is an independent risk factor for atherosclerosis, might cause dysregulation of gene expression, but the characteristics and key links involved in its pathogenic mechanisms are still poorly understood.The objective present study was to investigate effect HHcy on DNA methylation underlying mechanism homocysteine (Hcy)-induced methylation.HHcy induced Sprague-Dawley rats after 4 weeks a low, medium or high methionine diet.The levels total homocysteine,...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with risk of cancer. Its etiology unknown, possibly involving immune dysregulation inflammation. Study used DNA methylation (DNAme) single-cell RNA sequencing (scRNA-seq) to compare LS normal skin. A detailed DNAme profile was created, analyzing differentially methylated probes (DMPs) cell type-specific DMPs. EpiSCORE deconvolution infiltration analyses identified...
<p indent="0mm">MicroRNAs (miRNAs) have emerged as essential regulators that play important roles in the development of multiple systems. Recent studies identified significant for miRNAs progression cardiac hypertrophy. This study aims to investigate effects miR-133b-3p on angiotensin II (Ang II)-induced hypertrophy and apoptosis, well explore its underlying mechanisms. Our experimental results reveal expression is significantly decreased both animal cell models induced by Ang II....
Homocysteine (Hcy) has been recognized as a prevalent risk factor for cardiovascular events. Cholesterol-loaded foam cells are central component of atherosclerotic lesions. ATP-binding cassette transporter A1 (ABCA1), which mediates the efflux cellular cholesterol and phospholipids, is rate-limiting step in lipid metabolism. Acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT1) promotes accumulation ester macrophages, thereby resulting cell formation, hallmark early stage atherosclerosis. In...
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases, such as atherosclerosis. HHcy promotes atherogenesis by modifying the histone methylation patterns and miRNA regulation. In this study, we investigated effects of homocysteine (Hcy) on expression enhancer zeste homolog 2 (EZH2), tested our hypothesis that Hcy-induced atherosclerosis mediated increased EZH2 expression, which regulated miR-92a. The levels H3K27me3 were in aorta ApoE-/- mice fed a...
Homocysteine (Hcy) is an important and independent risk factor for arteriosclerosis, apolipoprotein E (ApoE) gene of anti atherosclerosis, but the characteristics their key links that are involved in pathogenic mechanisms still poorly understood. The objective present study was to investigate effects Hcy folate on ApoE as well underlying mechanism expression induced by monocytes. When clinically relevant concentrations were added cultured monocytes 4 days, we found (100 microM) may increase...
Homocysteine (Hcy) is an independent risk factor for cardiovascular disease, but the molecular mechanisms causing atherosclerosis in monocytes remain poorly characterized. The objective of present study was to investigate effects Hcy on DNA methylation PPARalpha,gamma and underlying mechanism expression that induced by monocytes. About 50, 100, 200, 500 microM were added cultured 48 h. acted as lipid sensors bind with mM affinities ligands antiatherosclerosis determined real-time reverse...
Homocysteine (Hcy) is a risk factor for atherosclerosis. It generally accepted that inducible nitric oxide synthase (iNOS) key enzyme in the regulation of vascular disease. The aim present study to investigate effects peroxisome proliferator-activated receptor ligands on iNOS presence Hcy human monocytes. Foam cells, induced by oxidize low density lipoprotein (ox-LDL) and phorbol myristate acetate (PMA) different concentrations Hcy, clofibrate pioglitazone monocytes 4 d, were examined oil...
Hyperhomocysteinemia (HHcy) is an independent risk factor for the development of atherosclerosis (AS), according to overwhelming number clinical and epidemiological studies. However, underlying pathogenic molecular mechanisms by which HHcy promotes AS remain be fully elucidated. Fatty acid binding protein 4 (FABP4) has been shown important in macrophage cholesterol trafficking. The objective present study was determine whether homocysteine (Hcy) accelerates through regulating FABP4, then...
Although a modest homocysteine (Hcy) elevation is associated with an increased cardiovascular risk, the underlying mechanisms whereby Hcy triggers accumulation of cholesterol and roles extracellular superoxide dismutase (EC-SOD) in development foam cells have not yet been elucidated. In this study, we found both numbers cholesterol, H(2)O(2) oxidized low-density lipoprotein content also increased. Levels EC-SOD were significantly suppressed by Hcy, however, while 5-azacytidine (AZC), potent...
Objective: To critically evaluate the efficacy of an α-blocker in improving ureteral-stent-related symptoms and preliminarily investigate difference between different types α-blockers. Methods: Relevant randomized controlled trials were identified through searching PubMed, Cochrane Library, Embase, other sources. After quality assessment data abstraction, direct comparison based on Ureteral Stent-related Symptom Questionnaire (USSQ) α-blockers control was performed by RevMan 5.3. Indirect...