A5025663254- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Inflammatory Biomarkers in Disease Prognosis
- Urological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Urologic and reproductive health conditions
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Prostate Cancer Treatment and Research
- Pituitary Gland Disorders and Treatments
- Cancer Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Genital Health and Disease
- Multiple and Secondary Primary Cancers
- Metastasis and carcinoma case studies
- Nephrotoxicity and Medicinal Plants
- Pelvic and Acetabular Injuries
- Cancer Cells and Metastasis
- Abdominal Surgery and Complications
- Surgical Simulation and Training
- Reconstructive Surgery and Microvascular Techniques
Peking University
2016-2025
Beijing Jishuitan Hospital
2020-2025
Capital Medical University
2024-2025
Peking University First Hospital
2016-2020
Beijing Administration Institute
2016
We evaluated differences in clinicopathological characteristics and oncologic outcomes between patients with upper tract urothelial carcinoma mainland China the United States.We retrospectively compiled data on treated surgically at tertiary care medical facilities States or from 1998 to 2015. Baseline demographics, comorbidities pathological features were evaluated. Oncologic end points, including intravesical recurrence cancer specific survival, obtained after excluding who received...
Lichen sclerosus (LS) is a chronic inflammatory disease affecting skin and mucosal tissues, particularly external genitalia, with risk of cancer. Its etiology unknown, possibly involving immune dysregulation inflammation. Study used DNA methylation (DNAme) single-cell RNA sequencing (scRNA-seq) to compare LS normal skin. A detailed DNAme profile was created, analyzing differentially methylated probes (DMPs) cell type-specific DMPs. EpiSCORE deconvolution infiltration analyses identified...
Purpose: The aim of this study was to evaluate the prognostic value aspartate transaminase/alanine transaminase (AST/ALT) ratio in a large Chinese cohort surgically treated for localized upper tract urothelial carcinoma (UTUC) using propensity score matching (PSM) analysis. Methods: Data 908 consecutive patients with UTUC who underwent radical nephroureterectomy (RNU) were retrospectively evaluated. endpoints prognosis progression-free survival (PFS), cancer-specific (CSS) and overall (OS)...
The key prognostic factor at the time of diagnosis upper tract urothelial carcinomas (UTUC) is whether tumor in muscle-invasive or non-muscle invasive stage. It critical to identify novel molecular biomarkers for early detection and target therapy. Plasma proteins secreted by tissues have excellent potential as UTUC. In this study, we conducted a systematic study plasma markers UTUC based on RNA-seq data from five paired adjacent noncancerous mucosa. Through bioinformatics analysis, found...
The aim of this study was to elucidate the prognostic value preoperative controlling nutritional status (CONUT) score, a new index based on total lymphocyte count, serum albumin concentration and cholesterol concentration, in patients with localized upper tract urothelial cancer (UTUC) after radical nephroureterectomy (RNU) using propensity score matching (PSM) analysis.We retrospectively reviewed 908 consecutive UTUC who underwent RNU between 1999 2015. Patients were divided into two groups...
Background: The transcription factor SRY-related HMG-box 2 (SOX2) plays important regulatory roles in diverse biological processes (cell proliferation, migration, invasion and tumorigenicity). However, the relationship between SOX2 upper tract urothelial carcinoma (UTUC) have not been intensively investigated. This study aims to analyze expression of UTUC as well predictive value for prognosis effect on tumor aggressiveness SOX2. Methods: Formalin-fixed, paraffin-embedded blocks containing...
Abstract Purpose No conclusion exists for the optimum duration of preoperative administration doxazosin (DOX) before adrenalectomy pheochromocytoma. The purpose this study is to investigate whether perioperative hemodynamics and postoperative outcomes are related DOX administration. Methods In total, 132 patients managed preoperatively with single α-receptor blocker were enrolled. All underwent pheochromocytoma in Department Urology, Peking University First Hospital, between January 2001...
Purpose . There is no consensus for the optimum duration of preoperative administration phenoxybenzamine (PXB) before adrenalectomy pheochromocytoma. The aim this study to investigate whether perioperative hemodynamics and postoperative outcomes are related PXB administration. Methods In total, 102 patients managed preoperatively with single α -receptor blocker were enrolled from 469 consecutive diagnosed histologically received surgical treatment in Department Urology, Peking University...
We aimed to compare oncological outcomes by surgery type (segmental ureterectomy [SU] vs. radical nephroureterectomy [RNU]) in a large cohort of patients with upper tract urothelial carcinoma (UTUC) the distal ureter.We performed retrospective analysis 219 UTUC ureter among 931 who underwent SU and RNU. Clinicopathological were evaluated. Cancer-specific survival (CSS), overall (OS), local recurrence-free (RFS), intravesical (IVRFS), contralateral survival, metastasis-free assessed...
Abstract Background The optimal acute management of patients with blunt straddle injury to the bulbar urethra remains in question. Conventionally, suprapubic diversion delayed urethroplasty can always be considered, if necessary, but role early endoscopic realignment (EER) injuries is controversial. We report our clinical experience and outcomes EER for a level one trauma center. Methods retrospectively reviewed 44 male who were transferred center between January 2013 2019 perineum leading...
Background: Studies regarding the prevalence and factors associated with severe pre-operative chronic kidney disease (CKD) in upper tract urinary carcinoma (UTUC) patients were rare due to low of UTUC. We conducted present study investigate prevalence, clinicopathological features, prognosis UTUC preoperative CKD. Methods: The included 731 treated radical nephroureterectomy (RNU) a large Chinese center. Estimated glomerular filtration rate (eGFR) was calculated by re-expressed Modification...
To analyze the effect of preoperative serum sodium and hemoglobin on oncologic outcomes in upper tract urothelial carcinoma (UTUC) based a multi-center cohort from China United States (U.S.).We retrospectively reviewed records 775 patients with UTUC treated surgically at tertiary care medical facilities or US 1998 to 2015. We analyzed associations clinicopathological characteristics, overall survival (OS), cancer-specific (CSS) intravesical recurrence free (IVRFS).The had comparatively lower...
Abstract Purpose To report our early experience of a novel surgical approach for penile urethral strictures after hypospadias repair, using lateral incision to keep the ventral tissue and vasculature penis intact avoid need interposition. Patients methods A total 21 patients underwent 1-stage urethroplasty with oral mucosal graft. The median age was years old (range, 13–47). number prior procedures repair 3 1–9) 18 (85.7%) undergoing greater than 1 reconstructive procedure. mean length 4.5 ±...
Aims: The prognostic significance of murine double minute 2 (MDM2) expression remains unknown in patients with upper tract urothelial carcinoma (UTUC). This study was designed to evaluate MDM2 and its association clinicopathological characteristics tumor outcomes UTUC patients. Materials Methods: Expression levels p53 were determined by immunohistochemistry a cohort 341 Associations characteristics, disease-free survival (DFS), cancer-specific (CSS), intravesical recurrence-free (IVRFS)...
You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma I1 Apr 2016PD13-03 A MULTI-INSTITUTIONAL EVALUATION OF CLINICAL AND TUMOR CHARACTERISTICS IN UPPER TRACT UROTHELIAL CARCINOMA FROM CHINA THE UNITED STATES Nirmish Singla, Ryan Hutchinson, Dong Fang, Xiaohong Su, Zhengqing Bao, Zhenpeng Cao, Syed Jafri, Gengyan Xiong, Lei Zhang, Arthur Sagalowsky, Yair Lotan, Xuesong Li, Liqun Zhou, Jay Raman, and Vitaly Margulis SinglaNirmish Singla More articles by this...
Objective: To investigate the clinical characteristics, treatment and prognosis of primary Penoscrotal extra-mammary Paget’s disease (PSPD).
Purpose: To evaluate the role of Prostate Imaging Reporting and Data System version 2 (PI-RADSv2) scores for estimating risk lymph node invasion (LNI) in prostate cancer (PCa).