A5103013025- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Antifungal resistance and susceptibility
- Fungal Infections and Studies
- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Prostate Cancer Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Peptidase Inhibition and Analysis
- Neurogenesis and neuroplasticity mechanisms
- Genital Health and Disease
- Ureteral procedures and complications
- Congenital heart defects research
- Inflammatory Biomarkers in Disease Prognosis
- Histone Deacetylase Inhibitors Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced Chemical Sensor Technologies
- Connective Tissue Growth Factor Research
- Nonmelanoma Skin Cancer Studies
- Genetic and Kidney Cyst Diseases
- HIV/AIDS oral health manifestations
Third Affiliated Hospital of Sun Yat-sen University
2021-2025
Sun Yat-sen University
2021-2025
Shihezi University
2025
Boston Children's Hospital
2007-2024
Southern Medical University
2017-2024
Gaozhou People's Hospital
2024
Zhujiang Hospital
2020-2023
Nanfang Hospital
2022
Peking University
2015-2020
Peking University First Hospital
2016-2020
Abstract Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 prostate (PCa) metastasis remains unclear. In this study, we performed vitro vivo to determine functions angiogenesis patients with metastatic PCa. We Glutathione-S-transferase pulldown, co-immunoprecipitation, western blotting gelatin degradation assays pathway mediating...
The class IIa histone deacetylases (HDACs) play important roles in the central nervous system during diverse biological processes such as synaptic plasticity, axon regeneration, cell apoptosis, and neural differentiation. Although it is known that HDAC5 regulates neuronal differentiation, neither physiological function nor regulation of differentiation clear. Here, we identify an inhibitor neurite elongation show regulated by brain enriched microRNA miR‐124 miR‐9. We discover inhibits...
We evaluated differences in clinicopathological characteristics and oncologic outcomes between patients with upper tract urothelial carcinoma mainland China the United States.We retrospectively compiled data on treated surgically at tertiary care medical facilities States or from 1998 to 2015. Baseline demographics, comorbidities pathological features were evaluated. Oncologic end points, including intravesical recurrence cancer specific survival, obtained after excluding who received...
To explore the mediating role of sleep duration in relationship between depression symptoms and myopia among middle school students. This study was a cross-sectional research conducted using stratified cluster random sampling method. A total 1 728 students were selected from two junior high schools senior certain urban areas farms Xinjiang Production Construction Corps. Questionnaire surveys vision tests Spearman analysis used to analyze correlation symptoms, duration, myopia. The Bootstrap...
The finely tuned bitter taste sensing in humans is orchestrated by a group of 25 receptors ( TAS 2Rs), which belong to the G ‐protein‐coupled receptor superfamily. 2Rs are expressed specialized bud cells gustatory system and perceive plethora substances with versatile structures. To date, more than one hundred ligands have been matched their cognate receptors, but understanding molecular mechanisms remains limited. Additionally, extraoral expression 2R genes was found gastrointestinal tract...
Background: The cAMP-PKA signaling pathway and TGF-β1-dependent fibrosis pathways are of particular importance in ADPKD progression, but the cross-talk between these remains unclear. Therefore, we used an MDCK-cell model embryonic kidney-cyst to study regulatory role TGF-β1 induced fibrotic process. Method Results: Pkd1flox/flox; Ksp-Cre Pkd1+/+; mice were as vivo model. Increased kidney volume, renal cysts formation up-regulation fibrosis-related proteins TGF-β1, connective tissue growth...
To determine the effect of diagnostic ureteroscopy on intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterec¬tomy (RNU).We conducted a retrospective analysis 664 who were treated RNU for UTUC from June 2000 to December 2011, excluding those had concomitant/prior bladder tumors. Of patients, 81 underwent di¬agnostic (URS). We analyzed impact (IVR) using Kaplan-Meier method. Univariate and multi¬variate analyses used independent risk...
Previous studies have reached diverse conclusions about the influence of tumor size on oncologic outcomes in patients with upper tract urothelial carcinoma (UTUC). In this study, we retrospectively analyzed records 687 and evaluated how affected prognosis UTUC after surgery. Clinicopathologic characteristics oncological were compared according to (≤3 cm versus >3 cm). During a median follow-up period 65 months (range 3-144 months), 225 (32.8%) died from 228 (33.2%) experienced intravesical...
Our previous study explored Amphotericin B (AMB) plus 5-flucytosine (5-FC) combined with fluconazole (FLU) therapy in the induction period, which seemed to be better than AMB + 5-FC antifungal non-HIV and non-transplant-associated CM. However, based on our clinical finding, outcomes of some CM patients who received FLU were still poor. Therefore, we need explore new methods during period.Clinical data from 148 admitted Third Affiliated Hospital Sun Yat Sen University January 2011 December...
Polycomb group (PcG) proteins regulate the epigenetic status of transcription regulatory states during development. Progression from pluripotency to differentiation requires sequential activation and repression different PcG target genes, however, relationship between early patterning signals, expression, development Central nervous system (CNS) is still unclear. Using various models neuronal differentiation, we provide evidence that CBX2 a negative regulator differentiation. Knock-down...
Abstract Background Bladder cancer (BCa) is the most common urinary malignancy. The standard surgical treatment for patients with muscle‐invasive BCa cystectomy plus diversion. Ileal conduit (IC) or orthotopic neobladder (ON), which have different indications, are commonly performed diversions. Methods and materials We sampled 5480 from Surveillance, Epidemiology, End Results (SEER) database 2004 to 2015. Kaplan‐Meier method log‐rank test was used assess cancer‐specific survival (CSS)...
// Xiaohong Su 1, 2, * , Han Hao Xuesong Li 2 Zhisong He Kan Gong Cuijian Zhang Lin Cai Qian Yao Yi Ding Yanqing Dong Fang Zheng Liqun Zhou 1 Department of Urology, Peking University First Hospital, Xicheng, Beijing, China Institute University, National Urological Cancer Center, These authors contributed equally to this work Correspondence to: Zhou, email: zhoulqmail@sina.com Zhang, doczhz@aliyun.com Keywords: fluorescence in situ hybridization (FISH), upper tract urothelial carcinoma...
To compare the efficacy and safety of photodynamic therapy (PDT) with overlapping multiple spots single spot for treating circumscribed choroidal hemangioma.Twenty-two patients (22 eyes) symptomatic hemangioma received PDT treatment. Fourteen (two to three spots) PDT, whereas eight single-spot PDT. Laser was used at 50J/cm(2) 83s in overlapping-spot group 166s group. Clinical examination, funduscopy, fluorescein angiography, ultrasonography were performed baseline after treatment.The mean...
Objective This research aims to study the correlation between serum immune factors and post-infectious inflammatory response syndrome (PIIRS) in immunocompetent cryptococcal meningitis (CM), explore whether could be used predict development of PIIRS. Methods A cohort 30 patients with PIIRS 87 without was selected from 347 CM patients. We analyzed general clinical information immunological indexes (cytokines, complement, immunoglobulin, inflammation, related cytological biochemical indexes)....
Abstract In multicellular organisms, receptor tyrosine kinases (RTKs) control a variety of cellular processes, including cell proliferation, differentiation, migration, and survival. Sprouty (SPRY) proteins represent an important class ligand‐inducible inhibitors RTK‐dependent signaling pathways. Here, we investigated the role SPRY1 in cells central nervous system (CNS). Expression was substantially higher neural stem than cortical neurons increased during neuronal differentiation neurons....