A5100429835- Cancer, Stress, Anesthesia, and Immune Response
- Tryptophan and brain disorders
- Fungal Infections and Studies
- Pharmacological Receptor Mechanisms and Effects
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
- Asthma and respiratory diseases
- Nutritional Studies and Diet
- Bacterial Infections and Vaccines
- Alzheimer's disease research and treatments
- Nail Diseases and Treatments
- Adrenal and Paraganglionic Tumors
- Autophagy in Disease and Therapy
- Immune cells in cancer
- Sodium Intake and Health
- Pituitary Gland Disorders and Treatments
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Folate and B Vitamins Research
- Plant Stress Responses and Tolerance
- Actinomycetales infections and treatment
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Infant Nutrition and Health
East China Normal University
2023-2025
Beijing Ditan Hospital
2024
Capital Medical University
2016-2024
Zhuzhou Central Hospital
2024
Central South University
2024
Heilongjiang University of Chinese Medicine
2022-2024
Beijing Chao-Yang Hospital
2024
Xi'an Jiaotong University
2021-2024
National Institute for Communicable Disease Control and Prevention
2024
National Taiwan University
2020-2023
G protein-coupled receptor 4 (GPR4) belongs to the subfamily of proton-sensing GPCRs (psGPCRs), which detect pH changes in extracellular environment and regulate diverse physiological responses. GPR4 was found be overactivated acidic tumor microenvironment as well inflammation sites, with a triad residues within transmembrane domain identified crucial for proton sensing. However, 3D structure remains unknown, roles other conserved psGPCRs are not understood. Here we report cryo-electron...
Telomeres are protective sequences of DNA capping the ends chromosomes that shorten over time. Leukocyte telomere length (LTL) is posited to reflect replicative history cells and general systemic aging organism. Chronic stress exposure leads accelerated LTL shortening, which has been linked increased susceptibility faster progression aging-related diseases. This study examined longitudinal associations between experiences racial discrimination, a qualitatively unique source minority...
Cichoric acid (CA), a polyphenol component from Echinacea purpurea, exhibits preventive effects on liver lipid-metabolism disorders in obesity. This research aimed to determine the role of circadian rhythm signaling during process CA-attenuated lipid accumulation hepatocytes. In current study, CA treatments improved cell morphology changes and hepatic levels, which were triggered by free fatty acids (2:1, oleate: palmitate) dose-dependent way. Besides, (200 μM) regulated expressions clock...
As signal molecules in aerobic organisms, locally accumulated ROS have been reported to balance cell division and differentiation the root meristem. Protein posttranslational modifications such as lysine acetylation play critical roles controlling a variety of cellular processes. However, mechanism by which regulate development is unknown. In addition, how protein regulated whether levels affect remain unclear.We aimed elucidate relationship between exploring rice mutant plant that displays...
We have previously shown that critically ill children transfused with red blood cells (RBCs) of longer storage durations more suppressed monocyte function after transfusion compared to fresher RBCs and older stored directly suppress in vitro, through unknown mechanisms. hypothesized RBC-derived microvesicles (MVs) were responsible for suppression.To determine the role RBC unit-derived MVs, we cocultured monocytes supernatants, isolated or supernatants had been depleted MVs from prestorage...
Nowadays, small-molecule drugs have become an indispensable part of tumor immunotherapy. Accumulating evidence has indicated that specifically blocking PGE2/EP4 signaling to induce robust antitumor immune response represents attractive immunotherapy strategy. Herein, a 2H-indazole-3-carboxamide containing compound 1 was identified as EP4 antagonist hit by screening our in-house library. Systematic structure–activity relationship exploration leads the discovery 14, which displayed...
Dysfunction of subcellular organelles initiates complex pathophysiological cascades and underlies numerous diseases, underscoring the need for organelle-specific therapeutic interventions. Precise spatiotemporal control reactive oxygen species (ROS) generation within offers a promising intervention approach. Herein, we report design synthesis novel series organelle-targeted, photoactivatable acetylperoxyl radical donors (ACR575s) based on an acetyl-caged rhodamine scaffold. Blue light...
Introduction: The currently available treatments for severe asthma are insufficient. Infiltration of neutrophils rather than eosinophils into the airways is an important inflammatory characteristic asthma. However, mechanism phenotypic change from eosinophilic to neutrophilic inflammation has not yet been fully elucidated. Methods: In current study, we examined effect lipopolysaccharides (LPS) on asthmatic mice sensitized with ovalbumin (OVA), as well roles interleukin (IL)-17A/T helper (Th)...
Oxidative stress is implicated in the pathogenesis of neurodegeneration and other aging-related diseases. Previous studies have found that whole herb Centipeda minima has remarkable antioxidant activities. However, there been no reports on neuroprotective effects C. , underlying mechanism its properties unclear. Here, we examined activities ethanol extract (ECM) both vivo vitro ECM treatment attenuated glutamate tert-butyl hydroperoxide (tBHP)-induced neuronal death, reactive oxygen species...
Abstract FcγR-mediated phagocytosis is accompanied by the generation of tissue-damaging products such as inflammatory cytokines and reactive oxygen species. Hence, phagocytic response must be a tightly regulated process. Recent studies have established that clustering FcγR on human myeloid cells causes tyrosine phosphorylation Src homology 2 domain-containing inositol polyphosphate phosphatase (SHIP). However, it not known how these immunoreceptor tyrosine-based activation motif...
Folate (vitamin B9) is the coenzyme involved in one-carbon transfer biochemical reactions essential for cell survival and proliferation, with its inadequacy causing developmental defects or severe diseases. Notably, mammalian cells lack ability to de novo synthesize folate but instead rely on intake from extracellular sources via specific transporters receptors, among which SLC19A1 ubiquitously expressed one tissues. However, mechanism of substrate recognition by remains unclear. Here we...
Abstract Context Glucocorticoids have potent effects on the central nervous system. However, while patients with Cushing syndrome frequently report impairments in cognitive function, studies investigating function autonomous cortisol secretion (ACS) adrenal incidentalomas (AIs) are scarce. Objective The aim of present study was to evaluate neurocognitive ACS. Methods We prospectively recruited 63 AI, 36 nonfunctional adenoma (NFA) (46.5 ± 10.5 years), and 27 ACS (48.6 9.1 years); these...
Background/Aims: Alzheimer disease (AD) is a common neurodegenerative that characterized by the deposition of beta-amyloid peptide and formation intracellular neurofibrillary tangles. Due to failure various clinical trials novel drugs for AD, effective AD treatment are urgently required. Methods: In this study, we used classic APP/PS1 mouse model explore neuroprotective effects new compound, bajijiasu, mechanisms involved. Behavioral tests western blotting were performed assess beneficial...
Growing evidences indicate that bacteria are associated with pathogenesis of neutrophilic asthma. However, the long-term effect airway bacterial colonization remains unclear. We sought to establish a murine model simulate inflammation colonization, and assess effects on allergic disease (AAD). BALB/c mice were sensitized twice subsequently challenged ovalbumin (OVA) exposed low-dose Haemophilus influenzae for approximately 2 months. Mice in treatment groups inhaled budesonide consecutively 6...
Background: Several epidemiological studies have reported the protective role of caffeine on health outcomes; however, it remained debatable consumption and brain amyloid positivity. Objective: We aimed to determine relationship between pathology in cognitively normal older adults. Methods: The dataset used for analysis this cross-sectional study was selected from Anti-Amyloid Treatment Asymptomatic Alzheimer’s (A4) Study. Multivariable logistic regression analyses were performed explore...
Circadian rhythm helps organisms adapt to their environment and control a variety of physiological metabolic processes. Acrylamide is toxic compound that can be produced during food processing. The aim this research investigate whether the circadian clock involved in toxicity mechanisms acrylamide mice liver. Our results revealed markedly induced gene oscillation disorder blocked circadian-related protein liver HepG2 cells. Simultaneously, balance daily antioxidant enzymes was impeded under...
// Haobin Cai 2, 1 , Yijie Wang Jiayang He Tiantian Jun Wu Jiansong Fang Rong Zhang Zhouke Guo 2 Li Guan Qinkai Zhan Lin 3 Yao Xiao 4 Huafeng Pan and Qi Institute of Clinical Pharmacology, Guangzhou University Chinese Medicine, 510405, China Department Neurology & Psychology, Shenzhen Traditional Medicine Hospital, 518033, Medical University, 510182, Correspondence to: Wang, email: wangqi@gzucm.edu.cn Pan, gzphf@126.com Keywords: dementia, bajijiasu, amyloid-β, cognitive impairment, APP/PS1...