A5022594818- Bone Tissue Engineering Materials
- Plant Molecular Biology Research
- Nanoplatforms for cancer theranostics
- Photosynthetic Processes and Mechanisms
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Plant Reproductive Biology
- Graphene and Nanomaterials Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Cellular Mechanics and Interactions
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
- Facilities and Workplace Management
- Medicinal Plant Pharmacodynamics Research
- Research in Cotton Cultivation
- Bacterial biofilms and quorum sensing
- Plant Virus Research Studies
- MicroRNA in disease regulation
- Plant-Microbe Interactions and Immunity
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Microtubule and mitosis dynamics
- Advanced Sensor and Energy Harvesting Materials
Shanghai Jiao Tong University
2017-2025
Shanghai Ninth People's Hospital
2017-2025
Tongji University
2020-2024
Purdue University West Lafayette
2015-2024
National Clinical Research
2022-2024
First Affiliated Hospital of Kunming Medical University
2024
Kunming Medical University
2024
Guodian Institute of Science and Technology
2024
Shanghai Hospital Development Center
2024
Michigan State University
2019-2023
The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired discovery that endoplasmic reticulum (ER) a state excessive stress and dysfunction under hyperglycemia, leading to osteogenic disorder, novel engineered exosome proposed modulate ER homeostasis for restoring function mesenchymal stem cells (MSCs). results indicate constructed exosomes efficiently regulate dramatically facilitate MSCs...
Electrospun scaffolds have been broadly studied to enhance bone regeneration because of the ability simulate structure and biological functions extracellular matrix. Polydopamine (PDA) is used coat various surfaces at a slightly basic pH (8-8.5) spontaneously reacts with nucleophilic functional groups. It suitable for surface modifications correlated formation. E7 newly discovered peptide specific affinity marrow mesenchymal stem cells (BMSCs). can be useful recruiting cells. Here,...
Bone tissue engineering has become one of the most effective methods to treat bone defects. Silk fibroin (SF) is a natural protein with no physiological activities, which features such as good biocompatibility and easy processing causes minimal inflammatory reactions in body. Scaffolds prepared by electrospinning SF can be used regeneration repair. Graphene oxide (GO) rich functional groups, biocompatibility, promotes osteogenic differentiation stem cells, while morphogenetic protein-2...
Injectable hydrogel is suitable for the repair of lacunar bone deficiency. This study fabricated an injectable, self-adaptive silk fibroin/mesoporous bioglass/sodium alginate (SMS) composite system. With controllable and adjustable physical chemical properties, SMS could be easily optimized adaptively to different clinical applications. The effectively showed great injectability shapeability, allowing defect filling with no gap. Moreover, displayed self-adaptability in mechanical...
Abstract Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected defects. Its recurrent resistant nature, high incidence rate, long‐term hospitalization, medical costs have driven efforts of scientific community to develop new therapies improve situation. Considering complex microenvironment persistent mechanisms mediated by bacteria, it is crucial an implant with enhanced osseointegration sustained effective infection clearance effects. Here, a...
Typically, bone regenerative medicine is applied to repair defects in patients with osteoporosis. Meanwhile, there an urgent need develop safe and cheap drugs that induce formation. Icariin, which reported promote the osteogenesis of stem cells vitro, main active component Herba Epimedii. However, whether icariin could caused by osteoporosis remains unknown. In this study, model rats was established ovariectomy first, then, osteogenic angiogenic differentiation mesenchymal (BMSCs) treated...
Neutrophils are fast-moving cells essential for host immune functions. Although they primarily rely on glycolysis ATP, isolated primary human neutrophils depend mitochondrial membrane potential chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo, and the underlying molecular mechanisms remain obscure. Here, we visualized an interconnected network that localizes to front rear of migrating using a novel transgenic zebrafish line. To disrupt function...
Healthcare buildings are characterized by complex energy systems and high usage, therefore serving as the key areas for achieving conservation goals in building sector. An accurate load prediction of hospital consumption is paramount importance to a successful healthcare management. In this study, eight machine learning models single ensemble were developed predicting facilities' consumption. To validate performance proposed model, an experiment was conducted on general Shanghai, China. It...
Developmental engineering strategy needs the biomimetic composites that can integrate progenitor cells, biomaterial matrices and bioactive signals to mimic natural bone healing process for faster reconstruction of segmental defects. We prepared gelatin-reduced graphene oxide (GOG) constructed mimicked procallus by combining GOG with photo-crosslinked gelatin hydrogel. The biological effects GOG-reinforced could induce bi-differentiation marrow stromal cells (BMSCs) rapid repair. proper ratio...
We has synthesized the biocompatible gelatin reduced graphene oxide (GOG) in previous research, and this study we would further evaluate its effects on bone remodeling aspects of osteoclastogenesis angiogenesis so as to verify impact accelerating orthodontic tooth movement. The mouse movement (OTM) model tests vivo showed that was accelerated GOG local injection group with more osteoclastic resorption neovascularization compared PBS group. analysis degradation marrow stromal stem cells...
Plants perceive microbe-associated molecular patterns and damage-associated to activate innate immune signaling events, such as bursts of reactive oxygen species (ROS). The actin cytoskeleton remodels during the first 5 min in Arabidopsis (Arabidopsis thaliana) epidermal cells; however, signals that impinge on its response regulators remain largely unknown. Here, we demonstrate rapid remodeling upon elicitation with diverse represent a conserved plant response. Actin requires ROS generated...
Despite extensive research, the origin and evolution of chloroplast division machinery remain unclear. Here, we employ recently sequenced genomes transcriptomes Archaeplastida clades to identify core components reconstruct their evolutionary histories, respectively. Our findings show that complete ring structures emerged in Charophytes. We find Glaucophytes experienced strong selection pressure, generating diverse variants adapted changing terrestrial environments. By integrating functions...
Periodontitis is a highly prevalent disease that affects up to 90% of the worldwide population. The dynamic oral environment, tissue-teeth "pocket" structure, and antimicrobial resistance pose challenges periodontitis local treatments, which urgently need be upgraded with advanced biomaterials novel therapeutics. Herein, new treatment strategy for proposed by synergistic nanozyme catalyzed phototherapeutic/chemodynamic sterilization microneedles (MNs) in situ delivery platform. A...
Actin filaments in plant cells are incredibly dynamic; they undergo incessant remodeling and assembly or disassembly within seconds. These dynamic events choreographed by a plethora of actin-binding proteins, but the exact mechanisms poorly understood. Here, we dissect contribution Arabidopsis (Arabidopsis thaliana) PROFILIN1 (PRF1), conserved actin monomer-binding protein, to organization single filament dynamics during axial cell expansion living epidermal cells. We found that reduced PRF1...
Abstract Ginsenoside Rb1, the effective constituent of ginseng, has been demonstrated to play favorable roles in improving immunity system. However, there is little study on osteogenesis and angiogenesis effect Rb1. Moreover, how establish a delivery system Rb1 its repairment ability bone defect remains elusive. In this study, role cell viability, proliferation, apoptosis, osteogenic genes expression, ALP activity rat BMSCs were evaluated firstly. Then, micro-nano HAp granules combined with...
In terrestrial plants a basal innate immune system, pattern-triggered immunity (PTI), has evolved to limit infection by diverse microbes. The remodeling of actin cytoskeletal arrays is now recognized as key hallmark event during the rapid host cellular responses pathogen attack. Several binding proteins have been demonstrated fine tune dynamics filaments this process. However, upstream signals that stimulate PTI signaling remain poorly characterized. Two second messengers, reactive oxygen...
Flexible hydrogel sensors have attracted significant attention due to their broad applications in soft robots, healthcare monitoring, and electronic skins.
The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded constraints of insufficient biofilm infiltration absence precision pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), UBI peptide to formulate an innovative nanosystem...
Kidney transplantation is the optimal form of renal replacement therapy, but long-term survival rate kidney graft has not improved significantly. Currently, no well-validated model exists for predicting over an extended observation period. Recipients undergoing allograft at Organ Transplantation Center First Affiliated Hospital Kunming Medical University from 1 August 2003 to 31 July 2023 were selected as study subjects. A nomogram was constructed based on least absolute selection and...