A5102401134- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Silk-based biomaterials and applications
- Orthopaedic implants and arthroplasty
- Magnesium Alloys: Properties and Applications
- Graphene and Nanomaterials Applications
- Dental Implant Techniques and Outcomes
- Surface Chemistry and Catalysis
- Molecular Junctions and Nanostructures
- Mesenchymal stem cell research
- Bone Metabolism and Diseases
- Electrospun Nanofibers in Biomedical Applications
- Corrosion Behavior and Inhibition
- Orthopedic Infections and Treatments
- Circular RNAs in diseases
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Chromatin Remodeling and Cancer
- Nonlinear Optical Materials Studies
- Bone and Dental Protein Studies
- Micro and Nano Robotics
Shanghai Jiao Tong University
2016-2025
Shanghai Ninth People's Hospital
2016-2025
National Clinical Research Center for Digestive Diseases
2022-2025
Shanghai Stomatological Hospital
2023-2025
Stomatology Hospital
2022
National Clinical Research
2019-2021
Indiana University School of Medicine
2016
Central South University
2015
Xiangya Hospital Central South University
2015
Chinese Academy of Sciences
2002-2004
Abstract The redevelopment/regeneration pattern of amputated limbs from a blastema in salamander suggests that enhanced regeneration might be achieved by mimicking the developmental microenvironment. Inspired discovery expression magnesium transporter‐1 (MagT1), selective (Mg) transporter, is significantly upregulated endochondral ossification region mouse embryos, Mg‐enriched 3D culture system proposed to provide an embryonic‐like environment for stem cells. First, optimum concentration Mg...
Thermal oxidation, which serves as a low-cost, effective and relatively simple/facile method, was used to modify micro-structured titanium surface in ambient atmosphere at 450 °C for different time periods improve vitro vivo bioactivity. The morphology, crystallinity of the layers, chemical composition states were evaluated by field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), photoelectron spectroscopy (XPS). Cell behaviours including cell adhesion, attachment,...
The regeneration of bone defects in diabetic patients still faces challenges, as the intrinsic healing process is impaired by hyperglycemia. Inspired discovery that endoplasmic reticulum (ER) a state excessive stress and dysfunction under hyperglycemia, leading to osteogenic disorder, novel engineered exosome proposed modulate ER homeostasis for restoring function mesenchymal stem cells (MSCs). results indicate constructed exosomes efficiently regulate dramatically facilitate MSCs...
Graphene has been studied for its in vitro osteoinductive capacity. However, the vivo bone repair effects of graphene‐based scaffolds remain unknown. The aqueous soluble graphene oxide‐copper nanocomposites (GO‐Cu) are fabricated, which used to coat porous calcium phosphate (CaP) vascularized regeneration. GO‐Cu nanocomposites, containing crystallized CuO/Cu 2 O nanoparticles ≈30 nm diameters, distribute uniformly on surfaces and maintain a long‐term release Cu ions. In vitro, coating...
Rapid osseointegration is recognized as a critical factor in determining the success rate of orthopedic and dental implants. Microarc oxidation (MAO) fabricated titanium oxide coatings with porous topography have been proven to be potent approach enhance osteogenic capacity. Now we report two kinds new hierarchical similar micromorphologies but different nanotopographies (i.e., MAO MAO-AK coatings), both significantly promote cell attachment differentiation through mediating integrin β1...
A multi-functional strontium incorporated titanium implant coating was fabricated to promote rapid osseointegration<italic>via</italic>inducing angiogenesis and osteogenesis.
The scaffold-free cell-sheet technique plays a significant role in stem-cell-based regeneration. Furthermore, growth factors are known to direct stem cell differentiation and enhance tissue However, the absence of an effective means incorporate into sheets hinders further optimization regeneration efficiency. Here, novel design magnetically controlled "growth-factor-immobilized sheets" is reported. A new Fe3 O4 magnetic nanoparticle (MNP) coated with nanoscale graphene oxide (nGO@Fe3 )...
Osteochondral repair remains a major challenge in current clinical practice despite significant advances tissue engineering. In particular, the lateral integration of neocartilage into surrounding native cartilage is difficult and inadequately addressed problem that determines success repair. Here, novel design an integral bilayer scaffold combined with photocurable silk sealant for osteochondral reported. First, we fabricated layer resembling surface morphology mechanical strength...
Abstract Senile wound healing risks a variety of health complications and makes both economic psychological burdens on patients greatly. Poor activity aged dermal fibroblasts (A‐FBs) local disordered immunoreaction in the deep dermis contribute to delayed healing. Therefore, locally complex microenvironment requires additional processing. Herein, novel double‐layer hyaluronic acid methacrylate (HAMA)/polyvinyl alcohol (PVA) microneedle patch (MNP) coated by young fibroblast‐derived exosomes...
Persistent bleeding and the absence of alveolar bone stress following tooth loss can hinder socket healing, complicating future dental implant procedures, potentially leading to neighboring instability. Therefore, developing materials that promote regeneration possess both hemostatic osteogenic properties is crucial for preserving extraction sites. This study introduces a silk-based laponite composite scaffold material with proficient functions, excellent shape-memory efficient extraction-...
Abstract Tissue engineering strategies to construct vascularized bone grafts are now attracting much attention. Strontium-hardystonite-Gahnite (Sr-HT-Gahnite) is a strong, highly porous, and biocompatible calcium silicate based bio-ceramic that contains strontium zinc ions. Adipose derived stem cells (ASCs) have been demonstrated the ability in promoting osteogenesis angiogenesis. In this study, effects of Sr-HT-Gahnite on cell morphology, proliferation, osteogenic differentiation ASCs were...
Abstract As societal aging intensifies, senile osteoporosis has become a global public health concern. Bone microdamage is mainly caused by processes such as enhancing osteoclast activity or reducing bone formation osteoblast-lineage cells. Compared with young individuals, extracellular vesicles derived from senescent marrow mesenchymal stem cells(BMSCs) increase the transient differentiation of monocytes (BMMs) to osteoclasts, ultimately leading and metal implant failure. To address this...
Abstract Antimicrobial resistance and impaired bone regeneration are the great challenges in treating infected defects. Its recurrent resistant nature, high incidence rate, long‐term hospitalization, medical costs have driven efforts of scientific community to develop new therapies improve situation. Considering complex microenvironment persistent mechanisms mediated by bacteria, it is crucial an implant with enhanced osseointegration sustained effective infection clearance effects. Here, a...
To control the degradation of magnesium alloy and enhance its osteoinduction activity antibacterial properties, we proposed addition Zn Sr ions in process surface modification (ZK60) by a one-pot hydrothermal process. We found that, after modification, materials formed cluster crystal structure coating layer, successful incorporation did not affect morphology microstructure. The corrosion resistance modified was significantly improved, cells grew well on material surfaces. released from...
Abstract Wound healing impairment in diabetes mellitus is associated with an excessive inflammatory response and defective regeneration capability suppressed Hedgehog (Hh) signaling. The bromodomain protein BRD9, a subunit of the non‐canonical BAF chromatin‐remodeling complex, critical for macrophage response. However, whether epigenetic drug BRD9 degrader can attenuate sustained state wounds remains unclear. Without bona fide immune microenvironment, Hh signaling activation fails to...