A5002314765- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Extracellular vesicles in disease
- Immune cells in cancer
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Connective tissue disorders research
- Plant tissue culture and regeneration
- Muscle Physiology and Disorders
- Transgenic Plants and Applications
- Plant-Microbe Interactions and Immunity
- interferon and immune responses
- Circular RNAs in diseases
- Cell Adhesion Molecules Research
Purdue University West Lafayette
2013-2020
Neutrophils are fast-moving cells essential for host immune functions. Although they primarily rely on glycolysis ATP, isolated primary human neutrophils depend mitochondrial membrane potential chemotaxis. However, it is not known whether mitochondria regulate neutrophil motility in vivo, and the underlying molecular mechanisms remain obscure. Here, we visualized an interconnected network that localizes to front rear of migrating using a novel transgenic zebrafish line. To disrupt function...
Natural bacterial cytokinins may help engineer crops with improved characteristics.
Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (MFN2) regulates homeostasis and chemotaxis in vivoMfn2-deficient neutrophils are released from the hematopoietic tissue, trapped vasculature zebrafish embryos, capable of chemotaxis. Consistent with this, human neutrophil-like cells deficient MFN2 fail to arrest activated endothelium under sheer...
Abstract Neutrophils rely on glycolysis for energy production. How mitochondria regulate neutrophil function is not fully understood. Here, we report that mitochondrial outer membrane protein Mitofusin 2 (Mfn2) regulates homeostasis in vivo. Mfn2 -deficient neutrophils are released from the hematopoietic tissue and trapped vasculature zebrafish embryos. Human neutrophil-like cells deficient with MFN2 fail to arrest activated endothelium under sheer stress or perform chemotaxis. Deletion of...