A5100727267- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Diabetes Treatment and Management
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Medicinal Plant Pharmacodynamics Research
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Pain Mechanisms and Treatments
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Ginseng Biological Effects and Applications
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
Shandong Normal University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2021-2025
Chongqing Medical University
2021-2025
Nanchong Central Hospital
2016-2025
North Sichuan Medical University
2025
Capital Medical University
2017-2025
Beijing University of Chinese Medicine
2025
Zhejiang Chinese Medical University
2025
Indiana Biosciences Research Institute
2024
Huazhong University of Science and Technology
2013-2024
Traumatic brain injury (TBI) is characterized by high mortality and disability rates. Disease-associated microglia (DAM) are a newly discovered subtype of microglia. However, their presence function in the acute phase TBI remain unclear. Although glycolysis important for microglial differentiation, its regulatory role DAM transformation during still In this study, we investigated functions DAM-like cells mice, as well relationship between glycolysis. controlled cortical impact model was used...
Intracerebral-ventricular (ICV) injection of streptozotocin (STZ) induces an insulin-resistant brain state that may underlie the neural pathogenesis sporadic Alzheimer disease (AD). Our previous work showed prior ICV treatment glucagon-like peptide-1 (GLP-1) could prevent STZ-induced learning memory impairment and tau hyperphosphorylation in rat brain. The Chinese herbal medicine geniposide is known to relieve symptoms type 2 diabetes. Because thought act as a GLP-1 receptor agonist, we...
Aging is a complex and inevitable biological process affected by combination of external environmental genetic factors. Humans are currently living longer than ever before, accompanied with aging-related alterations such as diminished autophagy, decreased immunological function, mitochondrial malfunction, stem cell failure, accumulation somatic DNA mutations, loss telomere, altered nutrient metabolism. leads to decline in body functions age-related diseases, for example, Alzheimer's disease,...
Abstract G protein-coupled receptors (GPCRs) constitute the largest family of membrane proteins and are important drug targets. The discovery drugs targeting these their protein signaling properties based on assays mainly performed with modified expressed in heterologous cells. However, GPCR responses may differ native environment. Here, by using highly sensitive i/o sensors, we reveal specific protein-mediated triggered GABA B , α 2 adrenergic cannabinoid CB1 primary neurons, different from...
Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown have therapeutic potential in some heart disorders, including ischaemic In this study, we demonstrate that bFGF administration can inhibit the endoplasmic reticulum (ER) stress and mitochondrial dysfunction induced a mouse model of I/R vitro, exerts protective effect by inhibiting ER response...
// Zhouguang Wang 1 , Yan Huang Yi Cheng Tan 1,2 Fenzan Wu Jiamin Hongxue Shi Hongyu Zhang Xichong Yu Hongchang Gao Li Lin Jun Cai 2 Jinsan Xiaokun Lu and Jian Xiao Chinese-American Research Institute for Diabetic Complications, School of Pharmaceutical Science, Key Laboratory Biotechnology Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China Department Pediatrics, Children's Hospital Institute, the University Louisville, Kentucky, USA Correspondence to: Xiao, email: Cai,...
Hyperhomocysteinemia is an independent risk factor for dementia, including Alzheimer's disease. Lowering homocysteine levels with folic acid treatment or without vitamin B12 has shown few clinical benefits on cognition. To verify the effect of emodin, a naturally active compound from Rheum officinale, hyperhomocysteinemia-induced rats were treated injection (HCY, 400 μg/kg/d, 2 weeks) via vena caudalis. Afterwards, HCY cognitive deficits administered intragastric emodin at different...
The cannabinoid receptor-2 (CB2R) was initially thought to be the "peripheral receptor." Recent studies, however, have documented CB2R expression in brain both glial and neuronal cells, increasing evidence suggests an important role for central nervous system inflammatory response. Intracerebral hemorrhage (ICH), which occurs when a diseased cerebral vessel ruptures, accounts 10-15% of all strokes. Although surgical techniques significantly advanced past two decades, ICH continues high...
Emerging evidence has suggested that microRNAs play a critical role in neuropathic pain development. However, the biological of miRNAs regulating remains barely known. In our present study, we found miR-124-3p was significantly downregulated rats after chronic sciatic nerve injury (CCI). addition, it showed overexpression obviously repressed mechanical allodynia and heat hyperalgesia. Meanwhile, been reported neuroinflammation can contribute lot to progression. Here, inflammatory cytokine...